BIOMAT Database Logo BIOMAT Database Logo

Effect of atenolol or enalapril on diurnal changes of blood pressure in Japanese mild to moderate hypertensives: a double-blind, randomised, crossover trial. 1991

T Takabatake, and H Ohta, and Y Yamamoto, and Y Ishida, and H Hara, and S Nakamura, and H Takakuwa, and K Kobayashi
Department of Internal Medicine, School of Medicine, Kanazawa University, Japan.

This randomised, double-blind, crossover study compared enalapril 5 mg, and atenolol 50 mg, each dosed once daily for 4 weeks, and investigated casual and diurnal BP changes using 24 hour ambulatory BP monitoring. Both atenolol and enalapril satisfactorily lowered BP during the day and no excessive falls occurred at night. The tendency for BP to increase during the day and decrease at night was maintained during both active periods. Pulse rate was reduced only by atenolol throughout 24 hours. The BP increase observed 2 hours after rising in the morning was suppressed by atenolol but not by enalapril. Both drugs reduced the rates of systolic (greater than or equal to 160 mmHg) and diastolic (greater than or equal to 95 mmHg) BP increases to half of those during placebo. The frequency with which diastolic BP increased above these limits was less during the atenolol period. The difference in BP between a hospital casual reading and the mean 24 hour ambulatory reading was reduced only by atenolol. Furthermore, only atenolol suppressed the BP and pulse rate increases on exercise.

UI MeSH Term Description Entries
D006973 Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D002940 Circadian Rhythm The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs or environmental and physiological stimuli. Diurnal Rhythm,Nyctohemeral Rhythm,Twenty-Four Hour Rhythm,Nycthemeral Rhythm,Circadian Rhythms,Diurnal Rhythms,Nycthemeral Rhythms,Nyctohemeral Rhythms,Rhythm, Circadian,Rhythm, Diurnal,Rhythm, Nycthemeral,Rhythm, Nyctohemeral,Rhythm, Twenty-Four Hour,Rhythms, Circadian,Rhythms, Diurnal,Rhythms, Nycthemeral,Rhythms, Nyctohemeral,Rhythms, Twenty-Four Hour,Twenty Four Hour Rhythm,Twenty-Four Hour Rhythms
D004311 Double-Blind Method A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment. Double-Masked Study,Double-Blind Study,Double-Masked Method,Double Blind Method,Double Blind Study,Double Masked Method,Double Masked Study,Double-Blind Methods,Double-Blind Studies,Double-Masked Methods,Double-Masked Studies,Method, Double-Blind,Method, Double-Masked,Methods, Double-Blind,Methods, Double-Masked,Studies, Double-Blind,Studies, Double-Masked,Study, Double-Blind,Study, Double-Masked
D004656 Enalapril An angiotensin-converting enzyme inhibitor that is used to treat HYPERTENSION and HEART FAILURE. Enalapril Maleate,MK-421,MK421,Renitec,Renitek,MK 421,Maleate, Enalapril
D005260 Female Females
D006339 Heart Rate The number of times the HEART VENTRICLES contract per unit of time, usually per minute. Cardiac Rate,Chronotropism, Cardiac,Heart Rate Control,Heartbeat,Pulse Rate,Cardiac Chronotropy,Cardiac Chronotropism,Cardiac Rates,Chronotropy, Cardiac,Control, Heart Rate,Heart Rates,Heartbeats,Pulse Rates,Rate Control, Heart,Rate, Cardiac,Rate, Heart,Rate, Pulse
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

T Takabatake, and H Ohta, and Y Yamamoto, and Y Ishida, and H Hara, and S Nakamura, and H Takakuwa, and K Kobayashi
A double-blind crossover trial of atenolol, enalapril and the fixed combination of atenolol and nifedipine in mild and moderate hypertension.
January 1993, The British journal of clinical practice,
T Takabatake, and H Ohta, and Y Yamamoto, and Y Ishida, and H Hara, and S Nakamura, and H Takakuwa, and K Kobayashi
Quality of life in hypertensives treated with atenolol or captopril: a double-blind crossover trial.
November 1992, Journal of hypertension,
T Takabatake, and H Ohta, and Y Yamamoto, and Y Ishida, and H Hara, and S Nakamura, and H Takakuwa, and K Kobayashi
A randomised double blind cross over trial of atenolol and propranolol in mild to moderate hypertension.
June 1987, The Journal of the Association of Physicians of India,
T Takabatake, and H Ohta, and Y Yamamoto, and Y Ishida, and H Hara, and S Nakamura, and H Takakuwa, and K Kobayashi
A double-blind crossover comparison of pindolol, metoprolol, atenolol and labetalol in mild to moderate hypertension.
April 1979, British journal of clinical pharmacology,
T Takabatake, and H Ohta, and Y Yamamoto, and Y Ishida, and H Hara, and S Nakamura, and H Takakuwa, and K Kobayashi
A double-blind crossover comparison of pindolol, metoprolol, atenolol and labetalol in mild to moderate hypertension.
January 1979, British journal of clinical pharmacology,
T Takabatake, and H Ohta, and Y Yamamoto, and Y Ishida, and H Hara, and S Nakamura, and H Takakuwa, and K Kobayashi
Blood pressure response to oral calcium in persons with mild to moderate hypertension. A randomized, double-blind, placebo-controlled, crossover trial.
December 1985, Annals of internal medicine,
T Takabatake, and H Ohta, and Y Yamamoto, and Y Ishida, and H Hara, and S Nakamura, and H Takakuwa, and K Kobayashi
A randomised double blind comparison of enalapril versus hydrochlorothiazide in elderly hypertensives.
April 1989, Journal of human hypertension,
T Takabatake, and H Ohta, and Y Yamamoto, and Y Ishida, and H Hara, and S Nakamura, and H Takakuwa, and K Kobayashi
Captopril compared to atenolol in mild to moderate hypertension in a randomized double-blind controlled trial.
February 1991, The Netherlands journal of medicine,
T Takabatake, and H Ohta, and Y Yamamoto, and Y Ishida, and H Hara, and S Nakamura, and H Takakuwa, and K Kobayashi
Double-blind randomised crossover trial of moderate sodium restriction in essential hypertension.
February 1982, Lancet (London, England),
T Takabatake, and H Ohta, and Y Yamamoto, and Y Ishida, and H Hara, and S Nakamura, and H Takakuwa, and K Kobayashi
A multicentric double blind randomised controlled trial of atenolol versus losartan as first line drug for mild to moderate essential hypertension.
December 2013, Journal of the Indian Medical Association,
Copied contents to your clipboard!