Biomaterial Database

A molecularly imprinted polymer-coated nanocomposite of magnetic nanoparticles for estrone recognition. 2009

Xin Wang, and Lianyan Wang, and Xiwen He, and Yukui Zhang, and Langxing Chen

Department of Chemistry, Nankai University, Tianjin 300071, PR China.

In this study, we synthesized Fe(3)O(4) magnetic nanoparticles coated estrone-imprinted polymer with controlled size using a semi-covalent imprinting strategy. In this protocol, the estrone-silica monomer complex (EstSi) was synthesized by the reaction 3-(triethoxysilyl)propyl isocyanate with estrone, where the template was linked to the silica coating on the iron oxide core via a thermally reversible bond. The removal of the template by a simple thermal reaction produced specific estrone recognition sites on the surface of silica shell.The resulting estrone-imprinted polymer coating Fe(3)O(4) magnetic hybrid nanoparticles exhibit a much higher specific recognition and saturation magnetization. The hybrid nanoparticles have been used for biochemical separation of estrone.

UI	MeSH Term	Description	Entries
D008280	Magnetics	The study of MAGNETIC PHENOMENA.	Magnetic
D008722	Methods	A series of steps taken in order to conduct research.	Techniques,Methodological Studies,Methodological Study,Procedures,Studies, Methodological,Study, Methodological,Method,Procedure,Technique
D004970	Estrone	An aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.	Folliculin (Hormone),Estrone, (+-)-Isomer,Estrone, (8 alpha)-Isomer,Estrone, (9 beta)-Isomer,Estrovarin,Kestrone,Unigen,Wehgen
D005290	Ferric Compounds	Inorganic or organic compounds containing trivalent iron.	Compounds, Ferric
D012822	Silicon Dioxide	Transparent, tasteless crystals found in nature as agate, amethyst, chalcedony, cristobalite, flint, sand, QUARTZ, and tridymite. The compound is insoluble in water or acids except hydrofluoric acid.	Silica,Aerosil,Aerosil 380,Cristobalite,Quso G-32,Quso G32,Tridymite,380, Aerosil,Dioxide, Silicon,G32, Quso,Quso G 32
D053758	Nanoparticles	Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.	Nanocrystalline Materials,Nanocrystals,Material, Nanocrystalline,Materials, Nanocrystalline,Nanocrystal,Nanocrystalline Material,Nanoparticle
D053761	Nanocomposites	Nanometer-scale composite structures composed of organic molecules intimately incorporated with inorganic molecules. (Glossary of Biotechnology and Nanobiotechology Terms, 4th ed)	Nanocomposite
D054802	Molecular Imprinting	A methodology for chemically synthesizing polymer molds of specific molecules or recognition sites of specific molecules. Applications for MOLECULARLY IMPRINTED POLYMERS (MIPs) include separations, assays and biosensors, and catalysis.	Molecular Imprinting Technique,Imprinting, Molecular,Imprinting Technique, Molecular,Imprinting Techniques, Molecular,Molecular Imprinting Techniques,Technique, Molecular Imprinting,Techniques, Molecular Imprinting
D020099	Coated Materials, Biocompatible	Biocompatible materials usually used in dental and bone implants that enhance biologic fixation, thereby increasing the bond strength between the coated material and bone, and minimize possible biological effects that may result from the implant itself.	Surface-Coated Materials,Biocompatible Coated Materials,Materials, Biocompatible Coated,Materials, Surface-Coated,Surface Coated Materials