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To analyze the effects of halothane, isoflurane, or enflurane on the ventilatory response to CO2, minute volume (VE), respiratory rate (f), occlusion pressure, mean inspiratory flow rate (VT/TI), and effective elastance (Pmax/VT) were measured in 26 patients during quiet breathing and when the respiratory system was stressed by CO2. Comparison was made at equipotent anesthetic concentration (1 MAC) and all measurements were made in the absence of surgical stimulation. Respiratory rate and Pmax/VT were unchanged in all groups after end-tidal CO2 was elevated. By contrast, VE, VT/TI, and occlusion pressure increased in all the groups when the respiratory system was stressed by CO2. Among the parameters tested delta VE/delta PaCO2 and delta VT/TI/delta PaCO2 were significantly (P less than 0.05) greater during halothane anesthesia than during isoflurane or enflurane anesthesia. We conclude that, at equipotent anesthetic concentrations, isoflurane and enflurane depress CO2 chemosensitivity more than halothane does, and that such effect is primarily related to the greater depressant effects of isoflurane and enflurane on the respiratory driving mechanisms.
Y Izumi, and
T Kochi, and
T Mizuguchi
February 1984,
Anesthesiology,
Y Izumi, and
T Kochi, and
T Mizuguchi
December 1987,
Anesthesia and analgesia,
Y Izumi, and
T Kochi, and
T Mizuguchi
March 1989,
Anesthesiology,
Y Izumi, and
T Kochi, and
T Mizuguchi
August 1984,
Anesthesiology,
Y Izumi, and
T Kochi, and
T Mizuguchi
January 1985,
Anaesthesia,
Y Izumi, and
T Kochi, and
T Mizuguchi
October 1977,
British journal of anaesthesia,
Y Izumi, and
T Kochi, and
T Mizuguchi
July 1976,
Chest,
Y Izumi, and
T Kochi, and
T Mizuguchi
September 1987,
European journal of anaesthesiology,
Y Izumi, and
T Kochi, and
T Mizuguchi
August 1979,
Anesthesiology,
Y Izumi, and
T Kochi, and
T Mizuguchi
April 1994,
Anesthesia and analgesia,
