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Thirty-three male Sprague-Dawley rats were fed a carcinogenic (0.064% 3'-methyl-4-dimethylaminoazobenzene, 3'-Me-DAB) ground meal normal diet. After 12 weeks the ground meal diet was replaced with a normal pellet diet, and the 30 surviving animals were divided into three equal groups. One group was sacrificed at the twelfth week and the other groups 4 and 8 weeks later. Control animals were also run. Based on previous studies which used "tumor-promoting" diets and 3'-Me-DAB, we expected a less than 100% incidence of predominantly hepatocellular carcinomas. However, we found mucin-producing cholangiocarcinomas in all 30 animals and, in addition, a small hepatocellular component in 3 of the animals. By electron microscopy the intestinal mucosal features of microvillous border cells, goblet cells, and endocrine-like cells were found. We suggest that the tumors produced as described here provide a good animal model of mucin-producing cholangiocarcinomas.
K P Reddy, and
R J Buschmann, and
B Chomet
December 1972,
The South African journal of medical sciences,
K P Reddy, and
R J Buschmann, and
B Chomet
January 1984,
Virchows Archiv. B, Cell pathology including molecular pathology,
K P Reddy, and
R J Buschmann, and
B Chomet
November 1961,
Cancer research,
K P Reddy, and
R J Buschmann, and
B Chomet
January 1994,
Anticancer research,
K P Reddy, and
R J Buschmann, and
B Chomet
April 1977,
Cancer research,
K P Reddy, and
R J Buschmann, and
B Chomet
July 1974,
Journal of the National Cancer Institute,
K P Reddy, and
R J Buschmann, and
B Chomet
August 1963,
Sapporo igaku zasshi. The Sapporo medical journal,
K P Reddy, and
R J Buschmann, and
B Chomet
September 1982,
Radioisotopes,
K P Reddy, and
R J Buschmann, and
B Chomet
January 1950,
Cancer research,
K P Reddy, and
R J Buschmann, and
B Chomet
July 1987,
Cancer letters,
