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The effects of the recombinant human cytokines interleukin 2 (IL-2) and IL-7 on the proliferation of T-acute lymphoblastic leukaemia (T-ALL) cells were tested in a clonogenic assay. Highly purified leukaemic cells were obtained by immunomagnetic depletion of mature T cells and fluorescence-activated cell sorting for immature leucocyte markers (CD1, CD10, CD34). Of 9 cases tested, only 3 showed evidence of stimulation by cytokines. One was stimulated by both IL-2 and IL-7, one by IL-2 only, and the third by IL-7 alone. A further case showed proliferation without addition of cytokines. The remaining 5 cases were completely unresponsive. While both IL-2 and IL-7 are capable of stimulating leukaemic cells from some cases of T-ALL, the molecules regulating the proliferation of T-ALL cells in vitro remain to be more fully elucidated.
V Makrynikola, and
A Kabral, and
K Bradstock
January 2015,
British journal of haematology,
V Makrynikola, and
A Kabral, and
K Bradstock
June 2006,
Cytopathology : official journal of the British Society for Clinical Cytology,
V Makrynikola, and
A Kabral, and
K Bradstock
February 1996,
Experimental hematology,
V Makrynikola, and
A Kabral, and
K Bradstock
November 2019,
Oncogene,
V Makrynikola, and
A Kabral, and
K Bradstock
March 1985,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
V Makrynikola, and
A Kabral, and
K Bradstock
January 1997,
Acta haematologica,
V Makrynikola, and
A Kabral, and
K Bradstock
April 1973,
Lancet (London, England),
V Makrynikola, and
A Kabral, and
K Bradstock
February 1994,
British journal of haematology,
V Makrynikola, and
A Kabral, and
K Bradstock
September 1985,
Scandinavian journal of haematology,
V Makrynikola, and
A Kabral, and
K Bradstock
July 1980,
Clinical and experimental immunology,
