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A 61-year-old woman had watery diarrhea, hypochlorhydria, hypokalemia, and elevated serum gastrin levels. She had islet cell carcinoma of the body of the pancreas with multiple metastases to the liver. Radioimmunoassay and immunofluorescence demonstrated both vasoactive intestinal polypeptide (VIP) and gastrin in the surgically removed carcinoma and in a metastatic focus. Electron microscopical findings confirmed the presence of two cell types whose secretory granules had characteristics ascribed to these two hormones. Plasma prostaglandin E levels were also elevated above normal. Serum VIP levels became elevated to the Verner-Morrison range prior to her death of a bleeding duodenal ulcer two years after initial symptoms.
D M Judge, and
L M Demers, and
D L Nahrwold, and
P S Dickman, and
R J Petrokubi, and
S Trapukdi
October 1985,
Archives of surgery (Chicago, Ill. : 1960),
D M Judge, and
L M Demers, and
D L Nahrwold, and
P S Dickman, and
R J Petrokubi, and
S Trapukdi
January 1997,
Anticancer research,
D M Judge, and
L M Demers, and
D L Nahrwold, and
P S Dickman, and
R J Petrokubi, and
S Trapukdi
October 1999,
Vnitrni lekarstvi,
D M Judge, and
L M Demers, and
D L Nahrwold, and
P S Dickman, and
R J Petrokubi, and
S Trapukdi
September 1995,
Orvosi hetilap,
D M Judge, and
L M Demers, and
D L Nahrwold, and
P S Dickman, and
R J Petrokubi, and
S Trapukdi
December 1975,
Annals of internal medicine,
D M Judge, and
L M Demers, and
D L Nahrwold, and
P S Dickman, and
R J Petrokubi, and
S Trapukdi
August 1978,
Postgraduate medical journal,
D M Judge, and
L M Demers, and
D L Nahrwold, and
P S Dickman, and
R J Petrokubi, and
S Trapukdi
July 1980,
The American journal of gastroenterology,
D M Judge, and
L M Demers, and
D L Nahrwold, and
P S Dickman, and
R J Petrokubi, and
S Trapukdi
December 1984,
Journal of affective disorders,
D M Judge, and
L M Demers, and
D L Nahrwold, and
P S Dickman, and
R J Petrokubi, and
S Trapukdi
March 1980,
Sheng li ke xue jin zhan [Progress in physiology],
D M Judge, and
L M Demers, and
D L Nahrwold, and
P S Dickman, and
R J Petrokubi, and
S Trapukdi
September 1980,
Clinics in gastroenterology,
