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Brain changes during the onset of schizophrenia: implications for neurodevelopmental theories. 2009
Stephen J Wood, and
Christos Pantelis, and
Alison R Yung, and
Dennis Velakoulis, and
Patrick D McGorry
Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Melbourne, VIC. sjwood@unimelb.edu.au
Neuroimaging studies of individuals at risk of psychosis have the potential to identify markers predictive of illness onset and features that progress with transition. To date, reduced brain volumes have shown weak predictive value for onset of psychotic illness. All published longitudinal studies of the transition to psychosis show progressive brain changes that are not seen in at-risk individuals who do not develop the disorder. Although the cause of these changes is unclear, they challenge the conventional neurodevelopmental model of schizophrenia.
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