-transparent.png){kind=logo}
BACKGROUND Lower testosterone levels are associated with anaemia in older men and women. The relation between testosterone and haemoglobin (Hb) in younger and middle-aged men is less well defined. The aim of the study was to examine the association between testosterone and Hb levels in men spanning middle to older ages. METHODS A cross-sectional analysis of 492 men aged 30.7-94.5 years from the Busselton Health Survey, Western Australia, was carried out. Haemoglobin (Hb), early-morning serum total testosterone and sex hormone-binding globulin (SHBG) were measured. Free testosterone was calculated using mass action equations. RESULTS Haemoglobin correlated to total and free testosterone concentrations (r= 0.13, P= 0.003 and r= 0.20, P < 0.001, respectively). Hb and SHBG were inversely correlated (r=-0.14, P= 0.001). Hb increased across lowest to highest quartiles of total testosterone (P= 0.02) and free testosterone (P < 0.001), but not SHBG. After adjusting for age, waist circumference, smoking status, alcohol consumption, renal function and ferritin, total testosterone was associated with Hb (beta= 0.037, P= 0.003) as was free testosterone (beta= 2.32, P < 0.001), whereas SHBG was not associated. CONCLUSIONS Testosterone concentration modulates Hb levels in community-dwelling men across a wide age range. Further studies are needed to clarify implications of this association between testosterone and Hb in men.
B B Yeap, and
J Beilin, and
Z Shi, and
M W Knuiman, and
J K Olynyk, and
D G Bruce, and
E A Milward
May 2011,
Clinical endocrinology,
B B Yeap, and
J Beilin, and
Z Shi, and
M W Knuiman, and
J K Olynyk, and
D G Bruce, and
E A Milward
September 2011,
Urology,
B B Yeap, and
J Beilin, and
Z Shi, and
M W Knuiman, and
J K Olynyk, and
D G Bruce, and
E A Milward
May 2021,
American journal of physiology. Heart and circulatory physiology,
B B Yeap, and
J Beilin, and
Z Shi, and
M W Knuiman, and
J K Olynyk, and
D G Bruce, and
E A Milward
July 2008,
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology,
B B Yeap, and
J Beilin, and
Z Shi, and
M W Knuiman, and
J K Olynyk, and
D G Bruce, and
E A Milward
April 2008,
Atherosclerosis,
B B Yeap, and
J Beilin, and
Z Shi, and
M W Knuiman, and
J K Olynyk, and
D G Bruce, and
E A Milward
May 2021,
The Journal of urology,
B B Yeap, and
J Beilin, and
Z Shi, and
M W Knuiman, and
J K Olynyk, and
D G Bruce, and
E A Milward
June 2017,
European urology,
B B Yeap, and
J Beilin, and
Z Shi, and
M W Knuiman, and
J K Olynyk, and
D G Bruce, and
E A Milward
April 2021,
Scientific reports,
B B Yeap, and
J Beilin, and
Z Shi, and
M W Knuiman, and
J K Olynyk, and
D G Bruce, and
E A Milward
October 2006,
Psychoneuroendocrinology,
B B Yeap, and
J Beilin, and
Z Shi, and
M W Knuiman, and
J K Olynyk, and
D G Bruce, and
E A Milward
March 2008,
Hormones and behavior,
