BIOMAT Database Logo BIOMAT Database Logo

HSP 70 and atherosclerosis--protector or activator? 2009

Agata Bielecka-Dabrowa, and Marcin Barylski, and Dimitri P Mikhailidis, and Jacek Rysz, and Maciej Banach
Department of Molecular Cardionephrology and Hypertension, Medical University of Lodz, Lodz, Poland.

BACKGROUND Atherosclerosis and its complications represent the leading cause of morbidity and mortality. Heat shock protein 70 (HSP70) protects cellular elements from injury by reducing oxidation, inflammation and apoptosis and by refolding damaged proteins. HSP70 improves viability of stressed vascular smooth muscle cells, possibly via its chaperone functions. It has been proposed that the response mounted against bacterial HSPs results in an autoimmune reaction, which has the potential to cause complement-mediated endothelial injury, and hence accelerate atherogenesis. OBJECTIVE to examine the roles of HSPs in atherosclerosis. METHODS A literature review. CONCLUSIONS The role of HSPs in atherosclerosis is controversial. HSP60 probably acts as an autoantigen, and may trigger both cell- and antibody-mediated immune responses, while HSP70 is likely to be involved in cytoprotection. The significance of this inverse relation between HSP70 and atherosclerosis has not yet been elucidated. Whether HSPs will become therapeutic targets remains to be established.

UI MeSH Term Description Entries
D002470 Cell Survival The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability. Cell Viability,Cell Viabilities,Survival, Cell,Viabilities, Cell,Viability, Cell
D004730 Endothelium, Vascular Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components. Capillary Endothelium,Vascular Endothelium,Capillary Endotheliums,Endothelium, Capillary,Endotheliums, Capillary,Endotheliums, Vascular,Vascular Endotheliums
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001324 Autoantigens Endogenous tissue constituents with the ability to interact with AUTOANTIBODIES and cause an immune response. Autoantigen,Autologous Antigen,Autologous Antigens,Self-Antigen,Self-Antigens,Antigen, Autologous,Antigens, Autologous,Self Antigen,Self Antigens
D050197 Atherosclerosis A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA. Atherogenesis,Atherogeneses,Atheroscleroses
D018834 Chaperonin 60 A group I chaperonin protein that forms the barrel-like structure of the chaperonin complex. It is an oligomeric protein with a distinctive structure of fourteen subunits, arranged in two rings of seven subunits each. The protein was originally studied in BACTERIA where it is commonly referred to as GroEL protein. Heat-Shock Proteins 60,hsp60 Family,GroEL Protein,GroEL Stress Protein,Heat-Shock Protein 60,hsp60 Protein,Heat Shock Protein 60,Heat Shock Proteins 60
D018840 HSP70 Heat-Shock Proteins A class of MOLECULAR CHAPERONES found in both prokaryotes and in several compartments of eukaryotic cells. These proteins can interact with polypeptides during a variety of assembly processes in such a way as to prevent the formation of nonfunctional structures. Heat-Shock Proteins 70,Heat Shock 70 kDa Protein,Heat-Shock Protein 70,HSP70 Heat Shock Proteins,Heat Shock Protein 70,Heat Shock Proteins 70,Heat-Shock Proteins, HSP70

Related Publications

Agata Bielecka-Dabrowa, and Marcin Barylski, and Dimitri P Mikhailidis, and Jacek Rysz, and Maciej Banach
HSP: helper, suppressor, protector.
February 2004, Kidney international,
Agata Bielecka-Dabrowa, and Marcin Barylski, and Dimitri P Mikhailidis, and Jacek Rysz, and Maciej Banach
[Heat shock protein: HSP 70 and HSP 60].
November 2004, Nihon rinsho. Japanese journal of clinical medicine,
Agata Bielecka-Dabrowa, and Marcin Barylski, and Dimitri P Mikhailidis, and Jacek Rysz, and Maciej Banach
Heat shock protein (Hsp) 70 is an activator of the Hsp104 motor.
May 2013, Proceedings of the National Academy of Sciences of the United States of America,
Agata Bielecka-Dabrowa, and Marcin Barylski, and Dimitri P Mikhailidis, and Jacek Rysz, and Maciej Banach
Nitric oxide in atherosclerosis: vascular protector or villain?
November 1998, Clinical and experimental pharmacology & physiology. Supplement,
Agata Bielecka-Dabrowa, and Marcin Barylski, and Dimitri P Mikhailidis, and Jacek Rysz, and Maciej Banach
Diagnostic yield of heat shock protein 70 (HSP-70) and anti-HSP-70 in Behcet-induced uveitis.
June 2013, Scandinavian journal of immunology,
Agata Bielecka-Dabrowa, and Marcin Barylski, and Dimitri P Mikhailidis, and Jacek Rysz, and Maciej Banach
Windows for HSP 70.
September 1996, Annals of the New York Academy of Sciences,
Agata Bielecka-Dabrowa, and Marcin Barylski, and Dimitri P Mikhailidis, and Jacek Rysz, and Maciej Banach
Expression of hsp 27, hsp 60, hsc 70, and hsp 70 by immortalized human proximal tubule cells (HK-2) following exposure to heat shock, sodium arsenite, or cadmium chloride.
August 2001, Journal of toxicology and environmental health. Part A,
Agata Bielecka-Dabrowa, and Marcin Barylski, and Dimitri P Mikhailidis, and Jacek Rysz, and Maciej Banach
Autophosphorylation of the 16 kDa and 70 kDa antigens (Hsp 16.3 and Hsp 70) of Mycobacterium tuberculosis.
July 2004, Microbiology (Reading, England),
Agata Bielecka-Dabrowa, and Marcin Barylski, and Dimitri P Mikhailidis, and Jacek Rysz, and Maciej Banach
Expression and prognostic examination of heat shock proteins (HSP 27, HSP 70, and HSP 90) in medulloblastoma.
July 2006, Journal of pediatric hematology/oncology,
Agata Bielecka-Dabrowa, and Marcin Barylski, and Dimitri P Mikhailidis, and Jacek Rysz, and Maciej Banach
Camptothecin inhibits hsp 70 heat-shock transcription and induces DNA strand breaks in hsp 70 genes in Drosophila.
January 1987, NCI monographs : a publication of the National Cancer Institute,
Copied contents to your clipboard!