-transparent.png){kind=logo}
OBJECTIVE Bone is perpetually absorbed and reformed, serving also to electrolyte homeostasis, mainly for calcium and phosphorus. Anticonvulsant medications are traditionally considered harmful to bone because of their interaction with the metabolism of vitamin D, due to hepatic enzyme induction. A study of the effect of anticonvulsant medications on mandibular bone quality was undertaken. METHODS 24 Wistar rats in three groups received diphenylhydantoin or diazepam or placebo intraperitoneally (i.p.). Absolute bone weight, bone to body weight ratio, specific bone weight, absolute calcium concentration, calcium to mandibular bone weight ratio and mineral element concentration were examined after animal sacrifice, three months later. From the results it may be concluded that diazepam and diphenylhydantoin administration affect the mandibular bone density and calcium content in terms of absolute weight and specific weight. Mandibular calcium concentration was affected only by diphenhylhydantoin treatment.
E M Parara, and
P B Galanopoulou, and
G Rallis, and
E Vairaktaris, and
C P Tesseromatis
September 2010,
Journal of musculoskeletal & neuronal interactions,
E M Parara, and
P B Galanopoulou, and
G Rallis, and
E Vairaktaris, and
C P Tesseromatis
August 1971,
British medical journal,
E M Parara, and
P B Galanopoulou, and
G Rallis, and
E Vairaktaris, and
C P Tesseromatis
January 1971,
Acta neurologica Scandinavica,
E M Parara, and
P B Galanopoulou, and
G Rallis, and
E Vairaktaris, and
C P Tesseromatis
August 1970,
Das Deutsche Gesundheitswesen,
E M Parara, and
P B Galanopoulou, and
G Rallis, and
E Vairaktaris, and
C P Tesseromatis
January 1994,
The Annals of pharmacotherapy,
E M Parara, and
P B Galanopoulou, and
G Rallis, and
E Vairaktaris, and
C P Tesseromatis
November 2009,
Archives of Iranian medicine,
E M Parara, and
P B Galanopoulou, and
G Rallis, and
E Vairaktaris, and
C P Tesseromatis
October 2001,
The British journal of nutrition,
E M Parara, and
P B Galanopoulou, and
G Rallis, and
E Vairaktaris, and
C P Tesseromatis
October 1981,
Clinical pharmacology and therapeutics,
E M Parara, and
P B Galanopoulou, and
G Rallis, and
E Vairaktaris, and
C P Tesseromatis
July 1992,
Lancet (London, England),
E M Parara, and
P B Galanopoulou, and
G Rallis, and
E Vairaktaris, and
C P Tesseromatis
May 1983,
Zhonghua fang she xue za zhi Chinese journal of radiology,
