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Cytotoxic prenylated flavonoids from the stem bark of Maackia amurensis. 2009

Xiong Li, and Dong Wang, and Ming-Yu Xia, and Zhi-Hui Wang, and Wei-Ning Wang, and Zheng Cui
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.

Five new prenylated flavonoids, maackiaflavanone A (1), maackiaflavanone B (2), maackiapentone (3), maackiapterocarpan A (4), maackiapterocarpan B (5) along with eleven known flavonoids were isolated from the stem bark of Maackia amurensis. The structures of the new compounds were elucidated by spectroscopic methods. The cytotoxicities of compounds 1-4, 6, 8-12 and 14-16 against four human cancer cell lines, A375S2, HeLa, MCF-7 and HepG2, were tested by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. Among the compounds tested, compound 2 showed the strongest cytotoxic activity with IC(50) value of 7.8 microM against A375S2 and euchrenone b(1) showed the most potent cytotoxicity with IC(50) value of 4.5 microM against HeLa.

UI MeSH Term Description Entries
D005419 Flavonoids A group of phenyl benzopyrans named for having structures like FLAVONES. 2-Phenyl-Benzopyran,2-Phenyl-Chromene,Bioflavonoid,Bioflavonoids,Flavonoid,2-Phenyl-Benzopyrans,2-Phenyl-Chromenes,2 Phenyl Benzopyran,2 Phenyl Benzopyrans,2 Phenyl Chromene,2 Phenyl Chromenes
D006367 HeLa Cells The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for, among other things, VIRUS CULTIVATION and PRECLINICAL DRUG EVALUATION assays. Cell, HeLa,Cells, HeLa,HeLa Cell
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000972 Antineoplastic Agents, Phytogenic Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity. Antineoplastics, Botanical,Antineoplastics, Phytogenic,Agents, Phytogenic Antineoplastic,Botanical Antineoplastics,Phytogenic Antineoplastic Agents,Phytogenic Antineoplastics
D045744 Cell Line, Tumor A cell line derived from cultured tumor cells. Tumor Cell Line,Cell Lines, Tumor,Line, Tumor Cell,Lines, Tumor Cell,Tumor Cell Lines
D054876 Prenylation Attachment of isoprenoids (TERPENES) to other compounds, especially PROTEINS and FLAVONOIDS. Farnesylation,Geranylgeranylation,Isoprenylation
D020128 Inhibitory Concentration 50 The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed to denote in vitro antibacterial activity, it is also used as a benchmark for cytotoxicity to eukaryotic cells in culture. IC50,Concentration 50, Inhibitory
D024301 Plant Bark The outer layer of the woody parts of plants. Bark, Plant,Bark, Tree,Tree Bark,Barks, Plant,Barks, Tree,Plant Barks,Tree Barks
D029901 Maackia A plant genus of the family FABACEAE. It contains a hemagglutinin. Maackia amurensis,Macckia,Maackia amurenses,Maackias,Macckias,amurensis, Maackia

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