[Association of polymorphisms of N372H in BRCA2 gene and 135G/C in RAD51 gene and breast cancers]. 2008

Rui Hu, and Yang Wei, and Wen-jun Jiang, and Wen-xiu Yao, and Qi-ming Long, and Jian-hui Zhang, and Ying Liang, and Xiao-lan Tang
Department of Mastologic Surgery, Sichuan Cancer Hospital, Sichuan Province, Chengdu 610041, China.

OBJECTIVE To determine the associations between the polymorphisms of N372H in BRCA2 gene and 135G/C in RAD51 gene and breast cancers. METHODS The allele and genotype frequencies of N372H in BRCA2 gene and 135G/C in RAD51 gene were analyzed with denaturing high performance liquid chromatography (DHPLC) and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 71 women with breast cancers and 85 normal, women. RESULTS The women with breast cancers had higher frequencies of genotype HH of the N372H locus in BRCA2 gene than the normal women. No statistical difference in the polymorphic distribution of 135G/C in RAD51 gene was observed between the two groups of women. CONCLUSIONS The genotype HH of the N372H locus in BRCA2 is associated with breast cancers, which might be a genetic risk factor for breast cancers in Chinese populations.

UI MeSH Term Description Entries
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D008969 Molecular Sequence Data Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. Sequence Data, Molecular,Molecular Sequencing Data,Data, Molecular Sequence,Data, Molecular Sequencing,Sequencing Data, Molecular
D012150 Polymorphism, Restriction Fragment Length Variation occurring within a species in the presence or length of DNA fragment generated by a specific endonuclease at a specific site in the genome. Such variations are generated by mutations that create or abolish recognition sites for these enzymes or change the length of the fragment. RFLP,Restriction Fragment Length Polymorphism,RFLPs,Restriction Fragment Length Polymorphisms
D001943 Breast Neoplasms Tumors or cancer of the human BREAST. Breast Cancer,Breast Tumors,Cancer of Breast,Breast Carcinoma,Cancer of the Breast,Human Mammary Carcinoma,Malignant Neoplasm of Breast,Malignant Tumor of Breast,Mammary Cancer,Mammary Carcinoma, Human,Mammary Neoplasm, Human,Mammary Neoplasms, Human,Neoplasms, Breast,Tumors, Breast,Breast Carcinomas,Breast Malignant Neoplasm,Breast Malignant Neoplasms,Breast Malignant Tumor,Breast Malignant Tumors,Breast Neoplasm,Breast Tumor,Cancer, Breast,Cancer, Mammary,Cancers, Mammary,Carcinoma, Breast,Carcinoma, Human Mammary,Carcinomas, Breast,Carcinomas, Human Mammary,Human Mammary Carcinomas,Human Mammary Neoplasm,Human Mammary Neoplasms,Mammary Cancers,Mammary Carcinomas, Human,Neoplasm, Breast,Neoplasm, Human Mammary,Neoplasms, Human Mammary,Tumor, Breast
D002681 China A country spanning from central Asia to the Pacific Ocean. Inner Mongolia,Manchuria,People's Republic of China,Sinkiang,Mainland China
D005260 Female Females
D005838 Genotype The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS. Genogroup,Genogroups,Genotypes
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D001483 Base Sequence The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence. DNA Sequence,Nucleotide Sequence,RNA Sequence,DNA Sequences,Base Sequences,Nucleotide Sequences,RNA Sequences,Sequence, Base,Sequence, DNA,Sequence, Nucleotide,Sequence, RNA,Sequences, Base,Sequences, DNA,Sequences, Nucleotide,Sequences, RNA

Related Publications

Rui Hu, and Yang Wei, and Wen-jun Jiang, and Wen-xiu Yao, and Qi-ming Long, and Jian-hui Zhang, and Ying Liang, and Xiao-lan Tang
May 2005, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology,
Rui Hu, and Yang Wei, and Wen-jun Jiang, and Wen-xiu Yao, and Qi-ming Long, and Jian-hui Zhang, and Ying Liang, and Xiao-lan Tang
June 2014, Familial cancer,
Rui Hu, and Yang Wei, and Wen-jun Jiang, and Wen-xiu Yao, and Qi-ming Long, and Jian-hui Zhang, and Ying Liang, and Xiao-lan Tang
May 2008, Pathology international,
Rui Hu, and Yang Wei, and Wen-jun Jiang, and Wen-xiu Yao, and Qi-ming Long, and Jian-hui Zhang, and Ying Liang, and Xiao-lan Tang
January 2011, Breast cancer research and treatment,
Rui Hu, and Yang Wei, and Wen-jun Jiang, and Wen-xiu Yao, and Qi-ming Long, and Jian-hui Zhang, and Ying Liang, and Xiao-lan Tang
January 2014, Diagnostic pathology,
Rui Hu, and Yang Wei, and Wen-jun Jiang, and Wen-xiu Yao, and Qi-ming Long, and Jian-hui Zhang, and Ying Liang, and Xiao-lan Tang
December 2022, Journal of cancer research and therapeutics,
Rui Hu, and Yang Wei, and Wen-jun Jiang, and Wen-xiu Yao, and Qi-ming Long, and Jian-hui Zhang, and Ying Liang, and Xiao-lan Tang
December 2007, American journal of human genetics,
Rui Hu, and Yang Wei, and Wen-jun Jiang, and Wen-xiu Yao, and Qi-ming Long, and Jian-hui Zhang, and Ying Liang, and Xiao-lan Tang
November 2005, Breast cancer research and treatment,
Rui Hu, and Yang Wei, and Wen-jun Jiang, and Wen-xiu Yao, and Qi-ming Long, and Jian-hui Zhang, and Ying Liang, and Xiao-lan Tang
March 2017, Breast cancer (Tokyo, Japan),
Rui Hu, and Yang Wei, and Wen-jun Jiang, and Wen-xiu Yao, and Qi-ming Long, and Jian-hui Zhang, and Ying Liang, and Xiao-lan Tang
January 2015, International journal of clinical and experimental medicine,
Copied contents to your clipboard!