Methamphetamine protects against stress-induced gastric mucosal lesions in mice. 2009

Masafumi Tomita, and Toshiko Okuyama, and Masayuki Nata, and Hironobu Katsuyama, and Kazuo Hidaka, and Yoko Watanabe, and Takemi Otsuki, and Fumio Moriya, and Hideo Ishizu
Department of Medical Toxicology, Kawasaki Medical School, Kurashiki, Japan. toxicology@med.kawasaki-m.ac.jp

Stress-induced gastric mucosal injury is a common clinical entity. On the other hand, abuse of methamphetamine (MA) represents a growing social problem. MA users are frequently in stressful situations. In this study, we examined the effects of MA on gastric injury, corticosterone level and immunomodulation using a water-immersion restraint stress (WRS) mouse model that is well known to induce gastric lesions. Mice were randomly divided into five groups: (1) the normal group, (2) the 3 hour (3 h)-WRS group, (3) the 6 hour (6 h)-WRS group, (4) the MA (3 mg/kg) plus 6 h-WRS group and (5) the MA (30 mg/kg) plus 6h-WRS group. As expected, most animals examined (above 90%) showed gastric injury after the WRS exposure. However, administration of MA at both 3 and 30 mg/kg resulted in significant suppression of the injury. The corticosterone levels were increased by exposure to the stress and/or MA, but there was no difference between these groups. The levels of the serum cytokines IL-6, IL-10 and TNF were increased by WRS, and were markedly increased by MA plus WRS; in particular, the level of IL-6 was synergistically increased. On the contrary, the level of IL-1beta was significantly decreased by WRS and MA plus WRS. This is the first report showing the protective effect of MA on stress-induced gastric injury, although further study is necessary to resolve the mechanism of MA-driven suppression of the injury.

UI MeSH Term Description Entries
D007101 Immersion The placing of a body or a part thereof into a liquid. Submersion,Immersions,Submersions
D008297 Male Males
D008694 Methamphetamine A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug of abuse and is referred to as crank, crystal, crystal meth, ice, and speed. Deoxyephedrine,Desoxyephedrine,Desoxyn,Madrine,Metamfetamine,Methamphetamine Hydrochloride,Methylamphetamine,N-Methylamphetamine,Hydrochloride, Methamphetamine,N Methylamphetamine
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D003345 Corticosterone An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)
D005753 Gastric Mucosa Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones. Cardiac Glands,Gastric Glands,Pyloric Glands,Cardiac Gland,Gastric Gland,Gastric Mucosas,Gland, Cardiac,Gland, Gastric,Gland, Pyloric,Glands, Cardiac,Glands, Gastric,Glands, Pyloric,Mucosa, Gastric,Mucosas, Gastric,Pyloric Gland
D006471 Gastrointestinal Hemorrhage Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM. Hematochezia,Hemorrhage, Gastrointestinal,Gastrointestinal Hemorrhages,Hematochezias
D000697 Central Nervous System Stimulants A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here. Analeptic,Analeptic Agent,Analeptic Drug,Analeptics,CNS Stimulant,CNS Stimulants,Central Nervous System Stimulant,Central Stimulant,Analeptic Agents,Analeptic Drugs,Central Stimulants,Agent, Analeptic,Agents, Analeptic,Drug, Analeptic,Drugs, Analeptic,Stimulant, CNS,Stimulant, Central,Stimulants, CNS,Stimulants, Central
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013312 Stress, Physiological The unfavorable effect of environmental factors (stressors) on the physiological functions of an organism. Prolonged unresolved physiological stress can affect HOMEOSTASIS of the organism, and may lead to damaging or pathological conditions. Biotic Stress,Metabolic Stress,Physiological Stress,Abiotic Stress,Abiotic Stress Reaction,Abiotic Stress Response,Biological Stress,Metabolic Stress Response,Physiological Stress Reaction,Physiological Stress Reactivity,Physiological Stress Response,Abiotic Stress Reactions,Abiotic Stress Responses,Abiotic Stresses,Biological Stresses,Biotic Stresses,Metabolic Stress Responses,Metabolic Stresses,Physiological Stress Reactions,Physiological Stress Responses,Physiological Stresses,Reaction, Abiotic Stress,Reactions, Abiotic Stress,Response, Abiotic Stress,Response, Metabolic Stress,Stress Reaction, Physiological,Stress Response, Metabolic,Stress Response, Physiological,Stress, Abiotic,Stress, Biological,Stress, Biotic,Stress, Metabolic

Related Publications

Masafumi Tomita, and Toshiko Okuyama, and Masayuki Nata, and Hironobu Katsuyama, and Kazuo Hidaka, and Yoko Watanabe, and Takemi Otsuki, and Fumio Moriya, and Hideo Ishizu
August 2007, International journal of molecular medicine,
Masafumi Tomita, and Toshiko Okuyama, and Masayuki Nata, and Hironobu Katsuyama, and Kazuo Hidaka, and Yoko Watanabe, and Takemi Otsuki, and Fumio Moriya, and Hideo Ishizu
January 2002, Clinical and experimental pharmacology & physiology,
Masafumi Tomita, and Toshiko Okuyama, and Masayuki Nata, and Hironobu Katsuyama, and Kazuo Hidaka, and Yoko Watanabe, and Takemi Otsuki, and Fumio Moriya, and Hideo Ishizu
January 2010, BioFactors (Oxford, England),
Masafumi Tomita, and Toshiko Okuyama, and Masayuki Nata, and Hironobu Katsuyama, and Kazuo Hidaka, and Yoko Watanabe, and Takemi Otsuki, and Fumio Moriya, and Hideo Ishizu
February 2014, Biochemical pharmacology,
Masafumi Tomita, and Toshiko Okuyama, and Masayuki Nata, and Hironobu Katsuyama, and Kazuo Hidaka, and Yoko Watanabe, and Takemi Otsuki, and Fumio Moriya, and Hideo Ishizu
March 1979, American journal of surgery,
Masafumi Tomita, and Toshiko Okuyama, and Masayuki Nata, and Hironobu Katsuyama, and Kazuo Hidaka, and Yoko Watanabe, and Takemi Otsuki, and Fumio Moriya, and Hideo Ishizu
July 2014, World journal of gastroenterology,
Masafumi Tomita, and Toshiko Okuyama, and Masayuki Nata, and Hironobu Katsuyama, and Kazuo Hidaka, and Yoko Watanabe, and Takemi Otsuki, and Fumio Moriya, and Hideo Ishizu
August 2023, Toxicology letters,
Masafumi Tomita, and Toshiko Okuyama, and Masayuki Nata, and Hironobu Katsuyama, and Kazuo Hidaka, and Yoko Watanabe, and Takemi Otsuki, and Fumio Moriya, and Hideo Ishizu
October 2000, Journal of pineal research,
Masafumi Tomita, and Toshiko Okuyama, and Masayuki Nata, and Hironobu Katsuyama, and Kazuo Hidaka, and Yoko Watanabe, and Takemi Otsuki, and Fumio Moriya, and Hideo Ishizu
November 2019, European journal of pharmacology,
Masafumi Tomita, and Toshiko Okuyama, and Masayuki Nata, and Hironobu Katsuyama, and Kazuo Hidaka, and Yoko Watanabe, and Takemi Otsuki, and Fumio Moriya, and Hideo Ishizu
June 1965, Psychological reports,
Copied contents to your clipboard!