-transparent.png){kind=logo}
The effects of di-n-propylacetic acid (DPA) on sleep, for some years used as an anticonvulsive drug, has been investigated in 11 healthy volunteers using all-night sleep EEG recordings. DPA acts by an enhancement of the gamma-aminobutyric acid (GABA) level of the brain. Its influence on sleep seemed to be of interest on account of the metabolic relationship of GABA to other short chain fatty acids. After short-term application only a shortening of the time to fall asleep and of the waking time could be found, whereas under long-term administration a decrease in deep synchronous sleep could be observed. In contrast to the results known from animal studies no marked influence on REM sleep was observed. The action of DPA on sleep is similar to that of diphenylhydantoin. No so-called matitudinal 'hangover' could be revelaed in either drug;
E Schneider, and
B Ziegler, and
H Maxion
October 1981,
Metabolism: clinical and experimental,
E Schneider, and
B Ziegler, and
H Maxion
October 1972,
La Clinica terapeutica,
E Schneider, and
B Ziegler, and
H Maxion
March 1965,
Epilepsia,
E Schneider, and
B Ziegler, and
H Maxion
February 1976,
Arzneimittel-Forschung,
E Schneider, and
B Ziegler, and
H Maxion
January 1982,
Metabolism: clinical and experimental,
E Schneider, and
B Ziegler, and
H Maxion
September 2007,
Alternative medicine review : a journal of clinical therapeutic,
E Schneider, and
B Ziegler, and
H Maxion
July 1986,
Casopis lekaru ceskych,
E Schneider, and
B Ziegler, and
H Maxion
January 1977,
Acta paediatrica Belgica,
E Schneider, and
B Ziegler, and
H Maxion
February 1968,
Nihon seirigaku zasshi. Journal of the Physiological Society of Japan,
E Schneider, and
B Ziegler, and
H Maxion
January 1978,
Nihon rinsho. Japanese journal of clinical medicine,
