-transparent.png){kind=logo}
Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: target and linker-drug selection. 2009
Andrew G Polson, and
Jill Calemine-Fenaux, and
Pamela Chan, and
Wesley Chang, and
Erin Christensen, and
Suzanna Clark, and
Frederic J de Sauvage, and
Dan Eaton, and
Kristi Elkins, and
J Michael Elliott, and
Gretchen Frantz, and
Reina N Fuji, and
Alane Gray, and
Kristin Harden, and
Gladys S Ingle, and
Noelyn M Kljavin, and
Hartmut Koeppen, and
Christopher Nelson, and
Saileta Prabhu, and
Helga Raab, and
Sarajane Ross, and
Dion S Slaga, and
Jean-Philippe Stephan, and
Suzie J Scales, and
Susan D Spencer, and
Richard Vandlen, and
Bernd Wranik, and
Shang-Fan Yu, and
Bing Zheng, and
Allen Ebens
Genentech, Inc., South San Francisco, California, USA. polson@gene.com
Antibody-drug conjugates (ADC), potent cytotoxic drugs covalently linked to antibodies via chemical linkers, provide a means to increase the effectiveness of chemotherapy by targeting the drug to neoplastic cells while reducing side effects. Here, we systematically examine the potential targets and linker-drug combinations that could provide an optimal ADC for the treatment for non-Hodgkin's lymphoma. We identified seven antigens (CD19, CD20, CD21, CD22, CD72, CD79b, and CD180) for potential treatment of non-Hodgkin's lymphoma with ADCs. ADCs with cleavable linkers mediated in vivo efficacy via all these targets; ADCs with uncleavable linkers were only effective when targeted to CD22 and CD79b. In target-independent safety studies in rats, the uncleavable linker ADCs showed reduced toxicity, presumably due to the reduced release of free drug or other toxic metabolites into the circulation. Thus, our data suggest that ADCs with cleavable linkers work on a broad range of targets, and for specific targets, ADCs with uncleavable linkers provide a promising opportunity to improve the therapeutic window for ADCs in humans.
Related Publications
Andrew G Polson, and
Jill Calemine-Fenaux, and
Pamela Chan, and
Wesley Chang, and
Erin Christensen, and
Suzanna Clark, and
Frederic J de Sauvage, and
Dan Eaton, and
Kristi Elkins, and
J Michael Elliott, and
Gretchen Frantz, and
Reina N Fuji, and
Alane Gray, and
Kristin Harden, and
Gladys S Ingle, and
Noelyn M Kljavin, and
Hartmut Koeppen, and
Christopher Nelson, and
Saileta Prabhu, and
Helga Raab, and
Sarajane Ross, and
Dion S Slaga, and
Jean-Philippe Stephan, and
Suzie J Scales, and
Susan D Spencer, and
Richard Vandlen, and
Bernd Wranik, and
Shang-Fan Yu, and
Bing Zheng, and
Allen Ebens
March 2013,
Future oncology (London, England),
Andrew G Polson, and
Jill Calemine-Fenaux, and
Pamela Chan, and
Wesley Chang, and
Erin Christensen, and
Suzanna Clark, and
Frederic J de Sauvage, and
Dan Eaton, and
Kristi Elkins, and
J Michael Elliott, and
Gretchen Frantz, and
Reina N Fuji, and
Alane Gray, and
Kristin Harden, and
Gladys S Ingle, and
Noelyn M Kljavin, and
Hartmut Koeppen, and
Christopher Nelson, and
Saileta Prabhu, and
Helga Raab, and
Sarajane Ross, and
Dion S Slaga, and
Jean-Philippe Stephan, and
Suzie J Scales, and
Susan D Spencer, and
Richard Vandlen, and
Bernd Wranik, and
Shang-Fan Yu, and
Bing Zheng, and
Allen Ebens
November 2015,
Pharmaceutical research,
Andrew G Polson, and
Jill Calemine-Fenaux, and
Pamela Chan, and
Wesley Chang, and
Erin Christensen, and
Suzanna Clark, and
Frederic J de Sauvage, and
Dan Eaton, and
Kristi Elkins, and
J Michael Elliott, and
Gretchen Frantz, and
Reina N Fuji, and
Alane Gray, and
Kristin Harden, and
Gladys S Ingle, and
Noelyn M Kljavin, and
Hartmut Koeppen, and
Christopher Nelson, and
Saileta Prabhu, and
Helga Raab, and
Sarajane Ross, and
Dion S Slaga, and
Jean-Philippe Stephan, and
Suzie J Scales, and
Susan D Spencer, and
Richard Vandlen, and
Bernd Wranik, and
Shang-Fan Yu, and
Bing Zheng, and
Allen Ebens
January 2013,
Methods in molecular biology (Clifton, N.J.),
Andrew G Polson, and
Jill Calemine-Fenaux, and
Pamela Chan, and
Wesley Chang, and
Erin Christensen, and
Suzanna Clark, and
Frederic J de Sauvage, and
Dan Eaton, and
Kristi Elkins, and
J Michael Elliott, and
Gretchen Frantz, and
Reina N Fuji, and
Alane Gray, and
Kristin Harden, and
Gladys S Ingle, and
Noelyn M Kljavin, and
Hartmut Koeppen, and
Christopher Nelson, and
Saileta Prabhu, and
Helga Raab, and
Sarajane Ross, and
Dion S Slaga, and
Jean-Philippe Stephan, and
Suzie J Scales, and
Susan D Spencer, and
Richard Vandlen, and
Bernd Wranik, and
Shang-Fan Yu, and
Bing Zheng, and
Allen Ebens
September 2010,
Leukemia,
Andrew G Polson, and
Jill Calemine-Fenaux, and
Pamela Chan, and
Wesley Chang, and
Erin Christensen, and
Suzanna Clark, and
Frederic J de Sauvage, and
Dan Eaton, and
Kristi Elkins, and
J Michael Elliott, and
Gretchen Frantz, and
Reina N Fuji, and
Alane Gray, and
Kristin Harden, and
Gladys S Ingle, and
Noelyn M Kljavin, and
Hartmut Koeppen, and
Christopher Nelson, and
Saileta Prabhu, and
Helga Raab, and
Sarajane Ross, and
Dion S Slaga, and
Jean-Philippe Stephan, and
Suzie J Scales, and
Susan D Spencer, and
Richard Vandlen, and
Bernd Wranik, and
Shang-Fan Yu, and
Bing Zheng, and
Allen Ebens
March 2015,
The AAPS journal,
Andrew G Polson, and
Jill Calemine-Fenaux, and
Pamela Chan, and
Wesley Chang, and
Erin Christensen, and
Suzanna Clark, and
Frederic J de Sauvage, and
Dan Eaton, and
Kristi Elkins, and
J Michael Elliott, and
Gretchen Frantz, and
Reina N Fuji, and
Alane Gray, and
Kristin Harden, and
Gladys S Ingle, and
Noelyn M Kljavin, and
Hartmut Koeppen, and
Christopher Nelson, and
Saileta Prabhu, and
Helga Raab, and
Sarajane Ross, and
Dion S Slaga, and
Jean-Philippe Stephan, and
Suzie J Scales, and
Susan D Spencer, and
Richard Vandlen, and
Bernd Wranik, and
Shang-Fan Yu, and
Bing Zheng, and
Allen Ebens
June 2024,
Analytical methods : advancing methods and applications,
Andrew G Polson, and
Jill Calemine-Fenaux, and
Pamela Chan, and
Wesley Chang, and
Erin Christensen, and
Suzanna Clark, and
Frederic J de Sauvage, and
Dan Eaton, and
Kristi Elkins, and
J Michael Elliott, and
Gretchen Frantz, and
Reina N Fuji, and
Alane Gray, and
Kristin Harden, and
Gladys S Ingle, and
Noelyn M Kljavin, and
Hartmut Koeppen, and
Christopher Nelson, and
Saileta Prabhu, and
Helga Raab, and
Sarajane Ross, and
Dion S Slaga, and
Jean-Philippe Stephan, and
Suzie J Scales, and
Susan D Spencer, and
Richard Vandlen, and
Bernd Wranik, and
Shang-Fan Yu, and
Bing Zheng, and
Allen Ebens
July 2007,
Blood,
Andrew G Polson, and
Jill Calemine-Fenaux, and
Pamela Chan, and
Wesley Chang, and
Erin Christensen, and
Suzanna Clark, and
Frederic J de Sauvage, and
Dan Eaton, and
Kristi Elkins, and
J Michael Elliott, and
Gretchen Frantz, and
Reina N Fuji, and
Alane Gray, and
Kristin Harden, and
Gladys S Ingle, and
Noelyn M Kljavin, and
Hartmut Koeppen, and
Christopher Nelson, and
Saileta Prabhu, and
Helga Raab, and
Sarajane Ross, and
Dion S Slaga, and
Jean-Philippe Stephan, and
Suzie J Scales, and
Susan D Spencer, and
Richard Vandlen, and
Bernd Wranik, and
Shang-Fan Yu, and
Bing Zheng, and
Allen Ebens
March 2020,
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting,
Andrew G Polson, and
Jill Calemine-Fenaux, and
Pamela Chan, and
Wesley Chang, and
Erin Christensen, and
Suzanna Clark, and
Frederic J de Sauvage, and
Dan Eaton, and
Kristi Elkins, and
J Michael Elliott, and
Gretchen Frantz, and
Reina N Fuji, and
Alane Gray, and
Kristin Harden, and
Gladys S Ingle, and
Noelyn M Kljavin, and
Hartmut Koeppen, and
Christopher Nelson, and
Saileta Prabhu, and
Helga Raab, and
Sarajane Ross, and
Dion S Slaga, and
Jean-Philippe Stephan, and
Suzie J Scales, and
Susan D Spencer, and
Richard Vandlen, and
Bernd Wranik, and
Shang-Fan Yu, and
Bing Zheng, and
Allen Ebens
June 2015,
The Lancet. Oncology,
Andrew G Polson, and
Jill Calemine-Fenaux, and
Pamela Chan, and
Wesley Chang, and
Erin Christensen, and
Suzanna Clark, and
Frederic J de Sauvage, and
Dan Eaton, and
Kristi Elkins, and
J Michael Elliott, and
Gretchen Frantz, and
Reina N Fuji, and
Alane Gray, and
Kristin Harden, and
Gladys S Ingle, and
Noelyn M Kljavin, and
Hartmut Koeppen, and
Christopher Nelson, and
Saileta Prabhu, and
Helga Raab, and
Sarajane Ross, and
Dion S Slaga, and
Jean-Philippe Stephan, and
Suzie J Scales, and
Susan D Spencer, and
Richard Vandlen, and
Bernd Wranik, and
Shang-Fan Yu, and
Bing Zheng, and
Allen Ebens
May 2017,
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences,
