Long-acting lanreotide in adolescent girls with constitutional tall stature. 2009

Jean-Claude Carel, and Joëlle Blumberg, and Muriel Bougeard-Julien, and Pierre Rochiccioli, and Jean-Louis Chaussain, and Maïthé Tauber, and
Department of Pediatric Endocrinology and Diabetology, INSERM U690 and Centre de Référence des Maladies Endocriniennes Rares de la Croissance, Robert Debré Hospital and University Paris 7 Denis Diderot, Paris, France. jean-claude.carel@inserm.fr

OBJECTIVE The aim of the study was to evaluate the efficacy and safety of lanreotide prolonged release (PR) 30 mg (long-acting lanreotide) in girls with constitutional tall stature (CTS). METHODS This open label prospective study included 35 girls (mean age 12.6 years) with CTS and a predicted adult height of >180 cm. Intramuscular injections of lanreotide PR 30 mg were given every 14 days, for a minimum of 12 months and up to 36 months. Adult height was compared with pretreatment predicted height. RESULTS The mean predicted adult height was reduced by 3.8 cm (95% CI 3.7-4.9 cm) in the restricted intent-to-treat population. Mean growth velocity decreased from 7.9 +/- 1.5 cm/year at preinclusion to 1.7 +/- 2.3 cm/year at the last visit on treatment (n = 35). Gastrointestinal adverse events and cholelithiasis were reported in 35/37 patients and 5/37 patients, respectively. There was 1 withdrawal due to gastrointestinal disorders. CONCLUSIONS Biweekly intramuscular lanreotide PR 30 mg given to girls with CTS after the onset of pubertal development reduced adult height as compared with predicted height. Treatment-associated adverse events were consistent with the overall safety profile of lanreotide 30 mg PR and did not deter most patients from long-term treatment.

UI MeSH Term Description Entries
D010456 Peptides, Cyclic Peptides whose amino acid residues are linked together forming a circular chain. Some of them are ANTI-INFECTIVE AGENTS; some are biosynthesized non-ribosomally (PEPTIDE BIOSYNTHESIS, NON-RIBOSOMAL). Circular Peptide,Cyclic Peptide,Cyclic Peptides,Cyclopeptide,Orbitide,Circular Peptides,Cyclopeptides,Orbitides,Peptide, Circular,Peptide, Cyclic,Peptides, Circular
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D001827 Body Height The distance from the sole to the crown of the head with body standing on a flat surface and fully extended. Body Heights,Height, Body,Heights, Body
D003692 Delayed-Action Preparations Dosage forms of a drug that act over a period of time by controlled-release processes or technology. Controlled Release Formulation,Controlled-Release Formulation,Controlled-Release Preparation,Delayed-Action Preparation,Depot Preparation,Depot Preparations,Extended Release Formulation,Extended Release Preparation,Prolonged-Action Preparation,Prolonged-Action Preparations,Sustained Release Formulation,Sustained-Release Preparation,Sustained-Release Preparations,Timed-Release Preparation,Timed-Release Preparations,Controlled-Release Formulations,Controlled-Release Preparations,Extended Release Formulations,Extended Release Preparations,Slow Release Formulation,Sustained Release Formulations,Controlled Release Formulations,Controlled Release Preparation,Controlled Release Preparations,Delayed Action Preparation,Delayed Action Preparations,Formulation, Controlled Release,Formulations, Controlled Release,Prolonged Action Preparation,Release Formulation, Controlled,Release Formulations, Controlled,Sustained Release Preparation,Timed Release Preparation,Timed Release Preparations
D005260 Female Females
D006130 Growth Disorders Deviations from the average values for a specific age and sex in any or all of the following: height, weight, skeletal proportions, osseous development, or maturation of features. Included here are both acceleration and retardation of growth. Stunted Growth,Stunting,Disorder, Growth,Growth Disorder,Growth, Stunted,Stuntings
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D013004 Somatostatin A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal. Cyclic Somatostatin,Somatostatin-14,Somatotropin Release-Inhibiting Hormone,SRIH-14,Somatofalk,Somatostatin, Cyclic,Somatotropin Release-Inhibiting Factor,Stilamin,Somatostatin 14,Somatotropin Release Inhibiting Factor,Somatotropin Release Inhibiting Hormone

Related Publications

Jean-Claude Carel, and Joëlle Blumberg, and Muriel Bougeard-Julien, and Pierre Rochiccioli, and Jean-Louis Chaussain, and Maïthé Tauber, and
December 1978, Pediatrics,
Jean-Claude Carel, and Joëlle Blumberg, and Muriel Bougeard-Julien, and Pierre Rochiccioli, and Jean-Louis Chaussain, and Maïthé Tauber, and
May 1981, Pediatric clinics of North America,
Jean-Claude Carel, and Joëlle Blumberg, and Muriel Bougeard-Julien, and Pierre Rochiccioli, and Jean-Louis Chaussain, and Maïthé Tauber, and
September 2006, Nihon rinsho. Japanese journal of clinical medicine,
Jean-Claude Carel, and Joëlle Blumberg, and Muriel Bougeard-Julien, and Pierre Rochiccioli, and Jean-Louis Chaussain, and Maïthé Tauber, and
November 1999, Harefuah,
Jean-Claude Carel, and Joëlle Blumberg, and Muriel Bougeard-Julien, and Pierre Rochiccioli, and Jean-Louis Chaussain, and Maïthé Tauber, and
January 1997, Journal of pediatric endocrinology & metabolism : JPEM,
Jean-Claude Carel, and Joëlle Blumberg, and Muriel Bougeard-Julien, and Pierre Rochiccioli, and Jean-Louis Chaussain, and Maïthé Tauber, and
October 1989, European journal of pediatrics,
Jean-Claude Carel, and Joëlle Blumberg, and Muriel Bougeard-Julien, and Pierre Rochiccioli, and Jean-Louis Chaussain, and Maïthé Tauber, and
September 1992, Clinical endocrinology,
Jean-Claude Carel, and Joëlle Blumberg, and Muriel Bougeard-Julien, and Pierre Rochiccioli, and Jean-Louis Chaussain, and Maïthé Tauber, and
June 1990, Akusherstvo i ginekologiia,
Jean-Claude Carel, and Joëlle Blumberg, and Muriel Bougeard-Julien, and Pierre Rochiccioli, and Jean-Louis Chaussain, and Maïthé Tauber, and
March 2008, Acta paediatrica (Oslo, Norway : 1992),
Jean-Claude Carel, and Joëlle Blumberg, and Muriel Bougeard-Julien, and Pierre Rochiccioli, and Jean-Louis Chaussain, and Maïthé Tauber, and
December 2000, Acta paediatrica (Oslo, Norway : 1992),
Copied contents to your clipboard!