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Molecular genetic diversity of hepatitis B virus in Kenya. 2008
Joseph Mwangi, and
Zipporah Nganga, and
Elijah Songok, and
Joyceline Kinyua, and
Nancy Lagat, and
Joseph Muriuki, and
Raphael Lihana, and
Samoel Khamadi, and
Saida Osman, and
Raphael Lwembe, and
Michael Kiptoo, and
Matilu Mwau, and
Ruth Chirchir, and
Solomon Mpoke, and
Jack Nyamongo, and
Fred Okoth, and
Rika Yamada, and
Seiji Kageyama, and
Hiroshi Ichimura
Centre for Virus Research, Kenya Medical Research Institute, Nairobi, Kenya. jmwangi@kemri.org
Eight genotypes of hepatitis B virus (A-H) and subgenotypes have been recognized worldwide. However, there is limited information on prevalent genotypes in many countries in Africa. This study was undertaken to determine the hepatitis B virus (HBV) genotypes in Kenya. Seropositive HBV blood samples from a blood donor setting were used in the study. HBV genotypes were determined in 52 nucleic acid-positive samples using specific primer in a nested PCR and sequencing employed in the HBV genotyping. This study shows presence of HBV variants with genotypes A (88%), E (8%) and D (4%). In conclusion, we found that HBV genotype A is the most predominant genotype in Kenya with both subgenotype A1 and A2 present. Genotype D and E are also present in our population. This demonstrates that there could be a high genetic diversity of HBV in Kenya.
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