Biomaterial Database

Effect of sublingual medication of sildenafil citrate/ apomorphine on sexual behaviour of male rats. 2009

X Huang, and C Xiong, and J Zhou, and J Shen

Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. huangxb@mails.tjmu.edu.cn

The study investigated the combined effect of sublingually administered sildenafil (SN) and apomorphine (APO SL) on the sexual behaviour of male rats. Male Sprague-Dawley rats (50) were divided into five groups (10 rats per each group): blank control, sildenafil group and SN plus APO SL high dosage, medium dosage and low dosage group. After sublingual administration of the agents (control and SN plus APO SL) and a sole dosage of sildenafil (stomach irrigation), the rats were mated with female counterparts in pairs, and the latent period of chasing, the frequency of chasing in 60 min, the latent period of mounting and the frequency of mounting in 60 min were recorded. The lower dosage of SN plus APO SL exerted a stronger influence on the sexual activities in male rats than did the higher sole dosage of sildenafil. Identification of common neurochemical and neuroanatomical substrates of sexual responding between animals and humans suggests that the evolution of sexual behaviour has been highly conserved and indicates that animal models of human sexual response can be used successfully as pre-clinical tools. So sublingual medication of SN combined with APO SL may be at least a support inference about male sexual libido.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D010879	Piperazines	Compounds that are derived from PIPERAZINE.
D011687	Purines	A series of heterocyclic compounds that are variously substituted in nature and are known also as purine bases. They include ADENINE and GUANINE, constituents of nucleic acids, as well as many alkaloids such as CAFFEINE and THEOPHYLLINE. Uric acid is the metabolic end product of purine metabolism.
D011897	Random Allocation	A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.	Randomization,Allocation, Random
D004338	Drug Combinations	Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.	Drug Combination,Combination, Drug,Combinations, Drug
D005260	Female		Females
D000068677	Sildenafil Citrate	A PHOSPHODIESTERASE TYPE-5 INHIBITOR; VASODILATOR AGENT and UROLOGICAL AGENT that is used in the treatment of ERECTILE DYSFUNCTION and PRIMARY PULMONARY HYPERTENSION.	1-((3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo(4,3-d)pyrimidin-5-yl)-4-ethoxyphenyl)sulfonyl)-4-methylpiperazine citrate,Acetildenafil,Desmethyl Sildenafil,Desmethylsildenafil,Homosildenafil,Hydroxyhomosildenafil,NCX-911,Revatio,Sildenafil,Sildenafil Lactate,Sildenafil Nitrate,UK 92480-10,UK-92,480-10,Viagra,Citrate, Sildenafil,Lactate, Sildenafil,NCX 911,NCX911,Nitrate, Sildenafil,Sildenafil, Desmethyl,UK 92,480 10,UK 92480 10,UK 9248010
D000286	Administration, Sublingual	Administration of a soluble dosage form by placement under the tongue.	Drug Administration, Sublingual,Sublingual Drug Administration,Sublingual Administration,Administration, Sublingual Drug,Administrations, Sublingual,Administrations, Sublingual Drug,Drug Administrations, Sublingual,Sublingual Administrations,Sublingual Drug Administrations
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001058	Apomorphine	A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use.	Apokinon,Apomorphin-Teclapharm,Apomorphine Chloride,Apomorphine Hydrochloride,Apomorphine Hydrochloride Anhydrous,Apomorphine Hydrochloride, Anhydrous,Apomorphine Hydrochloride, Hemihydrate,Britaject,Apomorphin Teclapharm