Effect of weak combined static and extremely low-frequency alternating magnetic fields on tumor growth in mice inoculated with the Ehrlich ascites carcinoma. 2009

Vadim V Novikov, and Gleb V Novikov, and Evgeny E Fesenko
Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia. docmag@mail.ru

It has been shown that the ultralow-frequency extremely weak alternating component of combined magnetic fields (MFs) exhibits a marked antitumor activity. The parameters of this component have been found (frequency 1, 4.4, 16.5 Hz or the sum of these frequencies; intensity 300, 100, 150-300 nT, respectively) at which this MF in combination with a collinear static MF of 42 microT inhibits or suppresses the growth of Ehrlich ascites carcinoma (EAC) in mice. It was shown that the exposure of mice with EAC to combined MFs causes structural changes in some organs (liver, adrenal glands), which are probably due to the total degradation of the tumor tissue. In mice with transplanted EAC, the tumor tissue after exposure to weak MFs was practically absent, as distinct from control animals in which the invasion of the tumor into the adipose tissue surrounding the kidneys, mesenteric lymph nodes, and spermatic appendages was observed. In animals without tumors, no pathological deviations from the norm in the structure of organs and tissues occurred after exposure to weak MF, indicating that this factor per se is not toxic to the organism.

UI MeSH Term Description Entries
D008280 Magnetics The study of MAGNETIC PHENOMENA. Magnetic
D008297 Male Males
D008807 Mice, Inbred BALB C An inbred strain of mouse that is widely used in IMMUNOLOGY studies and cancer research. BALB C Mice, Inbred,BALB C Mouse, Inbred,Inbred BALB C Mice,Inbred BALB C Mouse,Mice, BALB C,Mouse, BALB C,Mouse, Inbred BALB C,BALB C Mice,BALB C Mouse
D002286 Carcinoma, Ehrlich Tumor A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms. Ehrlich Ascites Tumor,Ascites Tumor, Ehrlich,Ehrlich Tumor Carcinoma,Tumor, Ehrlich Ascites
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D055909 Magnetic Field Therapy The magnetic stimulation of specific target tissues or areas of the body for therapeutic purposes via the application of magnetic fields generated by MAGNETS or ELECTROMAGNETS. Electrically-Charged Magnetic Therapy,Electromagnetic Therapy,Magnetotherapy,Static Magnetic Field Therapy,Magnetic Stimulation Therapy,Electrically Charged Magnetic Therapy,Electrically-Charged Magnetic Therapies,Electromagnetic Therapies,Magnetic Field Therapies,Magnetic Stimulation Therapies,Magnetic Therapies, Electrically-Charged,Magnetic Therapy, Electrically-Charged,Stimulation Therapy, Magnetic,Therapies, Electromagnetic,Therapies, Magnetic Field,Therapies, Magnetic Stimulation,Therapy, Electrically-Charged Magnetic,Therapy, Electromagnetic,Therapy, Magnetic Field,Therapy, Magnetic Stimulation

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