Animal models of suicide-trait-related behaviors. 2009

Oz Malkesman, and Daniel S Pine, and Tyson Tragon, and Daniel R Austin, and Ioline D Henter, and Guang Chen, and Husseini K Manji
Laboratory of Molecular Pathophysiology, National Institute of Mental Health, Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA.

Although antidepressants are moderately effective in treating major depressive disorder (MDD), concerns have arisen that selective serotonin-reuptake inhibitors (SSRIs) are associated with suicidal thinking and behavior, especially in children, adolescents and young adults. Almost no experimental research in model systems has considered the mechanisms by which SSRIs might be associated with this potential side effect in some susceptible individuals. Suicide is a complex behavior and impossible to fully reproduce in an animal model. However, by investigating traits that show strong cross-species parallels in addition to associations with suicide in humans, animal models might elucidate the mechanisms by which SSRIs are associated with suicidal thinking and behavior. Traits linked with suicide in humans that can be successfully modeled in rodents include aggression, impulsivity, irritability and hopelessness/helplessness. Modeling these relevant traits in animals can help to clarify the impact of SSRIs on these traits, suggesting avenues for reducing suicide risk in this vulnerable population.

UI MeSH Term Description Entries
D007175 Impulsive Behavior An act performed without delay, reflection, voluntary direction or obvious control in response to a stimulus. Impulsivity,Behavior, Impulsive,Behaviors, Impulsive,Impulsive Behaviors,Impulsivities
D007508 Irritable Mood Abnormal or excessive excitability with easily triggered anger, annoyance, or impatience. Mood, Irritable,Irritable Moods,Moods, Irritable
D003865 Depressive Disorder, Major Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5) Depression, Involutional,Major Depressive Disorder,Melancholia, Involutional,Paraphrenia, Involutional,Psychosis, Involutional,Depressive Disorders, Major,Involutional Depression,Involutional Melancholia,Involutional Paraphrenia,Involutional Paraphrenias,Involutional Psychoses,Involutional Psychosis,Major Depressive Disorders,Paraphrenias, Involutional,Psychoses, Involutional
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000374 Aggression Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism. Aggressions
D000375 Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time. Senescence,Aging, Biological,Biological Aging
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001519 Behavior The observable response of a man or animal to a situation. Acceptance Process,Acceptance Processes,Behaviors,Process, Acceptance,Processes, Acceptance
D013405 Suicide The act of killing oneself. Suicides

Related Publications

Oz Malkesman, and Daniel S Pine, and Tyson Tragon, and Daniel R Austin, and Ioline D Henter, and Guang Chen, and Husseini K Manji
January 2021, Anais da Academia Brasileira de Ciencias,
Oz Malkesman, and Daniel S Pine, and Tyson Tragon, and Daniel R Austin, and Ioline D Henter, and Guang Chen, and Husseini K Manji
January 1991, Journal of addictive diseases,
Oz Malkesman, and Daniel S Pine, and Tyson Tragon, and Daniel R Austin, and Ioline D Henter, and Guang Chen, and Husseini K Manji
June 1985, The Psychiatric clinics of North America,
Oz Malkesman, and Daniel S Pine, and Tyson Tragon, and Daniel R Austin, and Ioline D Henter, and Guang Chen, and Husseini K Manji
August 2018, ACS chemical neuroscience,
Oz Malkesman, and Daniel S Pine, and Tyson Tragon, and Daniel R Austin, and Ioline D Henter, and Guang Chen, and Husseini K Manji
April 2020, Journal of affective disorders,
Oz Malkesman, and Daniel S Pine, and Tyson Tragon, and Daniel R Austin, and Ioline D Henter, and Guang Chen, and Husseini K Manji
October 2018, Current opinion in behavioral sciences,
Oz Malkesman, and Daniel S Pine, and Tyson Tragon, and Daniel R Austin, and Ioline D Henter, and Guang Chen, and Husseini K Manji
March 1993, Behavior genetics,
Oz Malkesman, and Daniel S Pine, and Tyson Tragon, and Daniel R Austin, and Ioline D Henter, and Guang Chen, and Husseini K Manji
February 2009, Neuroscience letters,
Oz Malkesman, and Daniel S Pine, and Tyson Tragon, and Daniel R Austin, and Ioline D Henter, and Guang Chen, and Husseini K Manji
February 2023, Brain sciences,
Oz Malkesman, and Daniel S Pine, and Tyson Tragon, and Daniel R Austin, and Ioline D Henter, and Guang Chen, and Husseini K Manji
November 2021, Child and adolescent mental health,
Copied contents to your clipboard!