BIOMAT Database Logo BIOMAT Database Logo

Interspecies scaling of oleanolic acid in mice, rats, rabbits and dogs and prediction of human pharmacokinetics. 2009

Hye Young Ji, and Beom Soo Shin, and Dong Won Jeong, and Eun Jeong Park, and Eun-Seok Park, and Sun Dong Yoo, and Hye Suk Lee
Drug Metabolism & Bioanalysis Laboratory, College of Pharmacy, Wonkwang University, Iksan 570-749, Korea.

This study was conducted to predict the pharmacokinetics of oleanolic acid in humans based on animal data by allometry and several species-invariant time methods. Oleanolic acid was injected intravenously to mice, rats, rabbit and dogs (dose 1 mg/kg). The serum concentration-time profiles of oleanolic acid were best described by bi-exponential equation in all animal species. The average Cl, V ( ss ) and t ( 1/2 ) were 0.065 L/h, 0.019 L and 28.7 min in mice, 0.47 +/- 0.06 L/h, 0.117 +/- 0.029 L and 29.7 +/- 12.2 min in rats, 2.77 +/- 0.88 L/h, 1.83 +/- 0.60 L and 84.4 +/- 16.9 min in rabbits and 14.0 +/- 0.7 L/h, 9.2 +/- 10.1 L and 54.5 +/- 57.2 min in dogs, respectively. Based on animal data, human pharmacokinetic parameters of Cl, V ( ss ) and t (1/2) were predicted by simple allometry. In addition, actual concentration-time profiles obtained from animals were transformed to human profiles by species-invariant times of kallynochron, apolysichron and dienetichron. The predicted human pharmacokinetic parameters of Cl, V ( ss ) and t (1/2) by using simple allometry and species-invariant time transformation method ranged from 48.3-97.2 L/h, 49.1-92.9 L and 45.6-187.2 min, respectively. Those predicted parameters of oleanolic acid may be useful in designing dosing schedules of oleanolic acid in future clinical studies.

UI MeSH Term Description Entries
D007275 Injections, Intravenous Injections made into a vein for therapeutic or experimental purposes. Intravenous Injections,Injection, Intravenous,Intravenous Injection
D008297 Male Males
D008813 Mice, Inbred ICR An inbred strain of mouse that is used as a general purpose research strain, for therapeutic drug testing, and for the genetic analysis of CARCINOGEN-induced COLON CANCER. Mice, Inbred ICRC,Mice, ICR,Mouse, ICR,Mouse, Inbred ICR,Mouse, Inbred ICRC,ICR Mice,ICR Mice, Inbred,ICR Mouse,ICR Mouse, Inbred,ICRC Mice, Inbred,ICRC Mouse, Inbred,Inbred ICR Mice,Inbred ICR Mouse,Inbred ICRC Mice,Inbred ICRC Mouse
D008954 Models, Biological Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment. Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D009828 Oleanolic Acid A pentacyclic triterpene that occurs widely in many PLANTS as the free acid or the aglycone for many SAPONINS. It is biosynthesized from lupane. It can rearrange to the isomer, ursolic acid, or be oxidized to taraxasterol and amyrin. Oleanol,Hederins,Oleanane Triterpenes,Triterpenes, Oleanane
D011237 Predictive Value of Tests In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test. Negative Predictive Value,Positive Predictive Value,Predictive Value Of Test,Predictive Values Of Tests,Negative Predictive Values,Positive Predictive Values,Predictive Value, Negative,Predictive Value, Positive
D011817 Rabbits A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes. Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D002853 Chromatography, Liquid Chromatographic techniques in which the mobile phase is a liquid. Liquid Chromatography
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

Hye Young Ji, and Beom Soo Shin, and Dong Won Jeong, and Eun Jeong Park, and Eun-Seok Park, and Sun Dong Yoo, and Hye Suk Lee
Interspecies pharmacokinetic scaling of oltipraz in mice, rats, rabbits and dogs, and prediction of human pharmacokinetics.
April 2005, Biopharmaceutics & drug disposition,
Hye Young Ji, and Beom Soo Shin, and Dong Won Jeong, and Eun Jeong Park, and Eun-Seok Park, and Sun Dong Yoo, and Hye Suk Lee
Interspecies pharmacokinetic scaling of DA-8159, a new erectogenic, in mice, rats, rabbits and dogs, and prediction of human pharmacokinetics.
October 2005, Biopharmaceutics & drug disposition,
Hye Young Ji, and Beom Soo Shin, and Dong Won Jeong, and Eun Jeong Park, and Eun-Seok Park, and Sun Dong Yoo, and Hye Suk Lee
Interspecies pharmacokinetic scaling of a new carbapenem, DA-1131, in mice, rats, rabbits and dogs, and prediction of human pharmacokinetics.
May 1998, Biopharmaceutics & drug disposition,
Hye Young Ji, and Beom Soo Shin, and Dong Won Jeong, and Eun Jeong Park, and Eun-Seok Park, and Sun Dong Yoo, and Hye Suk Lee
Interspecies pharmacokinetic scaling of BSH in mice, rats, rabbits, and humans.
December 1995, Biopharmaceutics & drug disposition,
Hye Young Ji, and Beom Soo Shin, and Dong Won Jeong, and Eun Jeong Park, and Eun-Seok Park, and Sun Dong Yoo, and Hye Suk Lee
Cyclosporine pharmacokinetics in rats and interspecies comparison in dogs, rabbits, rats, and humans.
January 1988, Drug metabolism and disposition: the biological fate of chemicals,
Hye Young Ji, and Beom Soo Shin, and Dong Won Jeong, and Eun Jeong Park, and Eun-Seok Park, and Sun Dong Yoo, and Hye Suk Lee
Pharmacokinetics of the anti-inflammatory tiaprofenic acid in humans, mice, rats, rabbits, and dogs.
July 1977, Journal of pharmaceutical sciences,
Hye Young Ji, and Beom Soo Shin, and Dong Won Jeong, and Eun Jeong Park, and Eun-Seok Park, and Sun Dong Yoo, and Hye Suk Lee
Pharmacokinetics and interspecies scaling of recombinant human factor VIII.
January 1996, Toxicology and applied pharmacology,
Hye Young Ji, and Beom Soo Shin, and Dong Won Jeong, and Eun Jeong Park, and Eun-Seok Park, and Sun Dong Yoo, and Hye Suk Lee
Interspecies modeling and prediction of human exenatide pharmacokinetics.
March 2013, Pharmaceutical research,
Hye Young Ji, and Beom Soo Shin, and Dong Won Jeong, and Eun Jeong Park, and Eun-Seok Park, and Sun Dong Yoo, and Hye Suk Lee
Prediction of Human Pharmacokinetics of Ulixertinib, a Novel ERK1/2 Inhibitor from Mice, Rats, and Dogs Pharmacokinetics.
August 2018, European journal of drug metabolism and pharmacokinetics,
Hye Young Ji, and Beom Soo Shin, and Dong Won Jeong, and Eun Jeong Park, and Eun-Seok Park, and Sun Dong Yoo, and Hye Suk Lee
Approaches for predicting human pharmacokinetics using interspecies pharmacokinetic scaling.
November 2011, Archives of pharmacal research,
Copied contents to your clipboard!