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As part of a prospective cohort study initiated in 1983, the human immunodeficiency virus type 1 (HIV-1) status has been periodically determined for patients with clotting disorders (hemophilia A or B, von Willebrand's disease, miscellaneous). The University of North Carolina Hospitals has conducted comprehensive surveillance for nosocomial infections (NI) using modified Centers for Disease Control criteria since 1980 and entered this information in a computerized data base. Cross-matching of our NI data base and hemophiliac/HIV-1 study data base for the time period 1980-1989 revealed that 13 NI occurred in 11 patients during 659 hospitalizations (5,723 hospital days). NI rates per 100 admissions (per 1,000 hospital days) by HIV-1 status were as follows: HIV-1 negative = 0.91 (1.18), HIV-1 positive pre-AIDS = 1.65 (1.84), and AIDS = 6.67 (6.48). NI occurred with a similar frequency in HIV-1 positive pre-AIDS hemophiliacs and HIV-1 negative hemophiliacs (Fisher's exact test, p greater than 0.10). However, NI occurred more frequently in hemophiliacs with AIDS versus HIV-1 positive or negative hemophiliacs (Fisher's exact test, p less than 0.05). We conclude that HIV-1 infection does not appreciably alter the risk of developing a NI, but that patients who have progressed to AIDS are at significantly increased risk of developing a NI per hospital day or per hospitalization.
D J Weber, and
P R Becherer, and
W A Rutala, and
G P Samsa, and
M B Wilson, and
G C White
April 1988,
The Journal of infectious diseases,
D J Weber, and
P R Becherer, and
W A Rutala, and
G P Samsa, and
M B Wilson, and
G C White
January 1988,
Medicina clinica,
D J Weber, and
P R Becherer, and
W A Rutala, and
G P Samsa, and
M B Wilson, and
G C White
July 1995,
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D J Weber, and
P R Becherer, and
W A Rutala, and
G P Samsa, and
M B Wilson, and
G C White
October 1993,
Blood,
D J Weber, and
P R Becherer, and
W A Rutala, and
G P Samsa, and
M B Wilson, and
G C White
July 1990,
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D J Weber, and
P R Becherer, and
W A Rutala, and
G P Samsa, and
M B Wilson, and
G C White
August 1987,
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases,
D J Weber, and
P R Becherer, and
W A Rutala, and
G P Samsa, and
M B Wilson, and
G C White
June 1996,
Digestive diseases and sciences,
D J Weber, and
P R Becherer, and
W A Rutala, and
G P Samsa, and
M B Wilson, and
G C White
June 1994,
American journal of hematology,
D J Weber, and
P R Becherer, and
W A Rutala, and
G P Samsa, and
M B Wilson, and
G C White
April 1996,
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D J Weber, and
P R Becherer, and
W A Rutala, and
G P Samsa, and
M B Wilson, and
G C White
June 2005,
Current HIV/AIDS reports,
