BIOMAT Database Logo BIOMAT Database Logo

Effect of beta-lactamase inhibitors on the activities of various beta-lactam agents against anaerobic bacteria. 1991

H M Wexler, and E Molitoris, and S M Finegold
Medical Service, Veterans Administration Wadsworth Medical Center, Los Angeles, California 90073.

The in vitro activities of several new beta-lactam-beta-lactamase inhibitor combinations (piperacillin plus tazobactam, ceftizoxime and cefonicid with sulbactam and clavulanic acid, and ampicillin plus 8 micrograms of sulbactam per ml) were tested with anaerobic bacteria and compared with known beta-lactam-beta-lactamase inhibitor combinations and other potent antianaerobe agents. All the combinations tested (except for the cefonicid-inhibitor combinations) were active against almost all strains of the Bacteroides fragilis group. This report indicates that beta-lactamase inhibitors may improve the activity of beta-lactam agents with marginal activity against the B. fragilis group.

UI MeSH Term Description Entries
D008826 Microbial Sensitivity Tests Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses). Bacterial Sensitivity Tests,Drug Sensitivity Assay, Microbial,Minimum Inhibitory Concentration,Antibacterial Susceptibility Breakpoint Determination,Antibiogram,Antimicrobial Susceptibility Breakpoint Determination,Bacterial Sensitivity Test,Breakpoint Determination, Antibacterial Susceptibility,Breakpoint Determination, Antimicrobial Susceptibility,Fungal Drug Sensitivity Tests,Fungus Drug Sensitivity Tests,Sensitivity Test, Bacterial,Sensitivity Tests, Bacterial,Test, Bacterial Sensitivity,Tests, Bacterial Sensitivity,Viral Drug Sensitivity Tests,Virus Drug Sensitivity Tests,Antibiograms,Concentration, Minimum Inhibitory,Concentrations, Minimum Inhibitory,Inhibitory Concentration, Minimum,Inhibitory Concentrations, Minimum,Microbial Sensitivity Test,Minimum Inhibitory Concentrations,Sensitivity Test, Microbial,Sensitivity Tests, Microbial,Test, Microbial Sensitivity,Tests, Microbial Sensitivity
D000900 Anti-Bacterial Agents Substances that inhibit the growth or reproduction of BACTERIA. Anti-Bacterial Agent,Anti-Bacterial Compound,Anti-Mycobacterial Agent,Antibacterial Agent,Antibiotics,Antimycobacterial Agent,Bacteriocidal Agent,Bacteriocide,Anti-Bacterial Compounds,Anti-Mycobacterial Agents,Antibacterial Agents,Antibiotic,Antimycobacterial Agents,Bacteriocidal Agents,Bacteriocides,Agent, Anti-Bacterial,Agent, Anti-Mycobacterial,Agent, Antibacterial,Agent, Antimycobacterial,Agent, Bacteriocidal,Agents, Anti-Bacterial,Agents, Anti-Mycobacterial,Agents, Antibacterial,Agents, Antimycobacterial,Agents, Bacteriocidal,Anti Bacterial Agent,Anti Bacterial Agents,Anti Bacterial Compound,Anti Bacterial Compounds,Anti Mycobacterial Agent,Anti Mycobacterial Agents,Compound, Anti-Bacterial,Compounds, Anti-Bacterial
D001421 Bacteria, Anaerobic Bacteria that can survive and grow in the complete, or nearly complete absence of oxygen. Anaerobic Bacteria
D047090 beta-Lactams Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria. beta-Lactam,4-Thia-1-Azabicyclo(3.2.0)Heptanes,4-Thia-1-Azabicyclo(4.2.0)Octanes,beta Lactam,beta Lactams
D065093 beta-Lactamase Inhibitors Endogenous substances and drugs that inhibit or block the activity of BETA-LACTAMASES. beta Lactamase Inhibitor,beta Lactamase Inhibitors,beta-Lactamase Inhibitor,beta Lactamase Antagonists,Antagonists, beta Lactamase,Inhibitor, beta Lactamase,Inhibitor, beta-Lactamase,Inhibitors, beta Lactamase,Inhibitors, beta-Lactamase,Lactamase Antagonists, beta,Lactamase Inhibitor, beta,Lactamase Inhibitors, beta

Related Publications

H M Wexler, and E Molitoris, and S M Finegold
Effect of beta-lactamase inhibitors on beta-lactamases from anaerobic bacteria.
November 1992, European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology,
H M Wexler, and E Molitoris, and S M Finegold
Effect of beta-lactamase inhibitors on the antimicrobial activity of cefoperazone, cefotaxime, and ceftizoxime against aerobic and anaerobic beta-lactamase producing bacteria.
September 1987, Diagnostic microbiology and infectious disease,
H M Wexler, and E Molitoris, and S M Finegold
Susceptibility of anaerobic bacteria to beta-lactam antibiotics and beta-lactamase production.
February 1983, Journal of medical microbiology,
H M Wexler, and E Molitoris, and S M Finegold
Comparative activities of the beta-lactamase inhibitors YTR 830, clavulanic acid and sulbactam combined with ampicillin and piperacillin against beta-lactamase producing anaerobic bacteria.
July 1989, Journal of chemotherapy (Florence, Italy),
H M Wexler, and E Molitoris, and S M Finegold
[Progress in chemotherapeutic agents--beta-lactam antibiotics and beta-lactamase inhibitors].
April 1986, Nihon rinsho. Japanese journal of clinical medicine,
H M Wexler, and E Molitoris, and S M Finegold
In vitro activity of combinations of beta-lactam antibiotics with beta-lactamase inhibitors against cephalosporinase-producing bacteria.
September 1989, European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology,
H M Wexler, and E Molitoris, and S M Finegold
Inhibitory effect of clindamycin on production of beta-lactamase in beta-lactam-resistant bacteria.
May 1994, Biological & pharmaceutical bulletin,
H M Wexler, and E Molitoris, and S M Finegold
[Antibacterial activity of beta-lactam antibiotics against extended-spectrum beta-lactamase producing bacteria].
September 1999, The Japanese journal of antibiotics,
H M Wexler, and E Molitoris, and S M Finegold
Effect of pH on activities of novel beta-lactamases and beta-lactamase inhibitors against these beta-lactamases.
August 1995, Antimicrobial agents and chemotherapy,
H M Wexler, and E Molitoris, and S M Finegold
Anaerobic bacteria and beta-lactam antibiotics.
January 1984, Scandinavian journal of infectious diseases. Supplementum,
Copied contents to your clipboard!