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BACKGROUND Previous reports have indicated that statins could prevent bone loss in ovariectomized (OVX) rats and increase the expressions of osteogenic genes in cultured osteoblasts. In this study, we hypothesized that simvastatin might increase osteoblast number and protein expressions of osteogenic markers localized in bones in concomitance with the prevention of bone loss in OVX rats. METHODS Fifty-four 3-month-old OVX and sham-operated (SHAM) female Sprague-Dawley rats were used. Simvastatin (10-20 mg kg(-1) day(-1)) was administrated orally for 6 weeks. Trabecular volume, osteoblast number and osteogenic proteins including BMP2, collagen type I and osteocalcin on bone sections obtained from lumbar vertebral body, distal femur and proximal tibia were measured. RESULTS The results showed that SHAM rats had significantly less trabecular bone volume and osteoblast number than that of OVX rats 6 weeks after operation. Oral simvastatin treatment (10-20 mg kg(-1) day(-1)) increased bone volume and osteoblast number in the distal femurs, proximal tibiae and vertebrae of OVX rats. Furthermore, the osteoblastic cells with immuno-stained BMP2, collagen type I and osteocalcin in vertebral bones were significantly increased by simvastatin treatment (20 mg kg(-1) day(-1)) in OVX rats. CONCLUSIONS This study demonstrates that simvastatin enhances the production of osteogenic proteins in bone and this effect may contribute to the prevention of bone loss in OVX rats.
M-L Ho, and
Y-H Chen, and
H-J Liao, and
C-H Chen, and
S-H Hung, and
M-J Lee, and
Y-C Fu, and
Y-H Wang, and
G-J Wang, and
J-K Chang
September 2022,
Journal of anatomy,
M-L Ho, and
Y-H Chen, and
H-J Liao, and
C-H Chen, and
S-H Hung, and
M-J Lee, and
Y-C Fu, and
Y-H Wang, and
G-J Wang, and
J-K Chang
September 2015,
Biochemical and biophysical research communications,
M-L Ho, and
Y-H Chen, and
H-J Liao, and
C-H Chen, and
S-H Hung, and
M-J Lee, and
Y-C Fu, and
Y-H Wang, and
G-J Wang, and
J-K Chang
May 2013,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
M-L Ho, and
Y-H Chen, and
H-J Liao, and
C-H Chen, and
S-H Hung, and
M-J Lee, and
Y-C Fu, and
Y-H Wang, and
G-J Wang, and
J-K Chang
January 2016,
American journal of therapeutics,
M-L Ho, and
Y-H Chen, and
H-J Liao, and
C-H Chen, and
S-H Hung, and
M-J Lee, and
Y-C Fu, and
Y-H Wang, and
G-J Wang, and
J-K Chang
February 2018,
Cytotechnology,
M-L Ho, and
Y-H Chen, and
H-J Liao, and
C-H Chen, and
S-H Hung, and
M-J Lee, and
Y-C Fu, and
Y-H Wang, and
G-J Wang, and
J-K Chang
October 2011,
Journal of cellular biochemistry,
M-L Ho, and
Y-H Chen, and
H-J Liao, and
C-H Chen, and
S-H Hung, and
M-J Lee, and
Y-C Fu, and
Y-H Wang, and
G-J Wang, and
J-K Chang
March 2011,
Journal of bone and mineral metabolism,
M-L Ho, and
Y-H Chen, and
H-J Liao, and
C-H Chen, and
S-H Hung, and
M-J Lee, and
Y-C Fu, and
Y-H Wang, and
G-J Wang, and
J-K Chang
July 2008,
Molecular and cellular endocrinology,
M-L Ho, and
Y-H Chen, and
H-J Liao, and
C-H Chen, and
S-H Hung, and
M-J Lee, and
Y-C Fu, and
Y-H Wang, and
G-J Wang, and
J-K Chang
October 2001,
American journal of physiology. Regulatory, integrative and comparative physiology,
M-L Ho, and
Y-H Chen, and
H-J Liao, and
C-H Chen, and
S-H Hung, and
M-J Lee, and
Y-C Fu, and
Y-H Wang, and
G-J Wang, and
J-K Chang
February 2024,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
