Serologic evidence of Campylobacter jejuni/coli enteritis in patients with Guillain-Barré syndrome. 1991

R Gruenewald, and A H Ropper, and H Lior, and J Chan, and R Lee, and V S Molinaro
Enteric Bacteriology Laboratory, St Elizabeth's Hospital, Boston, MA 02135.

We performed serologic testing for Campylobacter jejuni in 17 consecutive patients with acute Guillain-Barré syndrome from the Boston, Mass area to compare the frequency of this preceding infection with the high rates reported from other areas of the world. The rate of seropositivity, 18%, was considerable, but it was lower than that reported in Australia. Moreover, all of our patients with definite serologic evidence of infection had severe enteritis before Guillain-Barré syndrome, usually with the organism cultured from stool samples. Campylobacter enteritis is an important antecedent illness for Guillain-Barré syndrome but did not precipitate the disease without enteritis.

UI MeSH Term Description Entries
D007136 Immunoglobulins Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses. Globulins, Immune,Immune Globulin,Immune Globulins,Immunoglobulin,Globulin, Immune
D011129 Polyradiculoneuropathy Diseases characterized by injury or dysfunction involving multiple peripheral nerves and nerve roots. The process may primarily affect myelin or nerve axons. Two of the more common demyelinating forms are acute inflammatory polyradiculopathy (GUILLAIN-BARRE SYNDROME) and POLYRADICULONEUROPATHY, CHRONIC INFLAMMATORY DEMYELINATING. Polyradiculoneuritis refers to inflammation of multiple peripheral nerves and spinal nerve roots. Autoimmune Demyelinating Disease, Peripheral,Demyelinating Autoimmune Disease, Peripheral,Demyelinating Disease, Peripheral Autoimmune,Peripheral Autoimmune Demyelinating Disease,Polyradiculoneuritis,Polyradiculoneuritides,Polyradiculoneuropathies
D002169 Campylobacter Infections Infections with bacteria of the genus CAMPYLOBACTER. Campylobacter Infection,Campylobacteriosis,Infections, Campylobacter,Campylobacterioses,Infection, Campylobacter
D004797 Enzyme-Linked Immunosorbent Assay An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed. ELISA,Assay, Enzyme-Linked Immunosorbent,Assays, Enzyme-Linked Immunosorbent,Enzyme Linked Immunosorbent Assay,Enzyme-Linked Immunosorbent Assays,Immunosorbent Assay, Enzyme-Linked,Immunosorbent Assays, Enzyme-Linked
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000907 Antibodies, Bacterial Immunoglobulins produced in a response to BACTERIAL ANTIGENS. Bacterial Antibodies
D016123 Campylobacter jejuni A species of bacteria that resemble small tightly coiled spirals. Its organisms are known to cause abortion in sheep and fever and enteritis in man and may be associated with enteric diseases of calves, lambs, and other animals. Campylobacter fetus subsp. jejuni,Vibrio hepaticus,Vibrio jejuni
D017000 Campylobacter coli A species of gram-negative, rod-shaped bacteria isolated from the intestinal tract of swine, poultry, and man. It may be pathogenic. Vibrio coli

Related Publications

R Gruenewald, and A H Ropper, and H Lior, and J Chan, and R Lee, and V S Molinaro
January 1984, The Journal of infection,
R Gruenewald, and A H Ropper, and H Lior, and J Chan, and R Lee, and V S Molinaro
December 1987, Archives of neurology,
R Gruenewald, and A H Ropper, and H Lior, and J Chan, and R Lee, and V S Molinaro
May 1990, Nederlands tijdschrift voor geneeskunde,
R Gruenewald, and A H Ropper, and H Lior, and J Chan, and R Lee, and V S Molinaro
August 1999, Rinsho byori. The Japanese journal of clinical pathology,
R Gruenewald, and A H Ropper, and H Lior, and J Chan, and R Lee, and V S Molinaro
June 1988, Archives of neurology,
R Gruenewald, and A H Ropper, and H Lior, and J Chan, and R Lee, and V S Molinaro
January 1999, Rinsho shinkeigaku = Clinical neurology,
R Gruenewald, and A H Ropper, and H Lior, and J Chan, and R Lee, and V S Molinaro
June 1993, Annals of internal medicine,
R Gruenewald, and A H Ropper, and H Lior, and J Chan, and R Lee, and V S Molinaro
April 1992, Pathology,
R Gruenewald, and A H Ropper, and H Lior, and J Chan, and R Lee, and V S Molinaro
January 1995, The Journal of pediatrics,
R Gruenewald, and A H Ropper, and H Lior, and J Chan, and R Lee, and V S Molinaro
June 1993, Zhonghua nei ke za zhi,
Copied contents to your clipboard!