-transparent.png){kind=logo}
We examined the relative abundance of G-protein subunits in postmortem brain obtained from 7 patients with bipolar affective disorder (BAD) compared with 7 age- and sex-matched controls. G-protein subunit immunoreactivities were determined in membranes prepared from postmortem prefrontal cortex using SDS-PAGE and immunoblotting with specific polyclonal antisera against selected G-protein subunits: Gsa, Gi(1&2) alpha, Go alpha and G beta(1&2). Of these G-protein subunits, only Gs alpha immunoreactivity was found to be significantly elevated in frontal (+ 34%), and occipital (+ 80%) cortex (P less than 0.05) in BAD compared with control subjects. Smaller increments (+ 22%) in cerebellar Gs alpha immunoreactivity were also found but were not statistically significant. On the basis that increased Gs alpha immunoreactivity may reflect enhanced functional responsiveness of the receptor-effector units to which this coupling protein is integral, the present findings suggest that disturbances in Gs-mediated signal transduction may be involved in the pathophysiology of BAD.
L T Young, and
P P Li, and
S J Kish, and
K P Siu, and
J J Warsh
February 1997,
The American journal of psychiatry,
L T Young, and
P P Li, and
S J Kish, and
K P Siu, and
J J Warsh
August 2003,
Brain research. Molecular brain research,
L T Young, and
P P Li, and
S J Kish, and
K P Siu, and
J J Warsh
November 1998,
Molecular psychiatry,
L T Young, and
P P Li, and
S J Kish, and
K P Siu, and
J J Warsh
November 1994,
Journal of affective disorders,
L T Young, and
P P Li, and
S J Kish, and
K P Siu, and
J J Warsh
March 2000,
Molecular psychiatry,
L T Young, and
P P Li, and
S J Kish, and
K P Siu, and
J J Warsh
July 2019,
The primary care companion for CNS disorders,
L T Young, and
P P Li, and
S J Kish, and
K P Siu, and
J J Warsh
December 2006,
Acta neuropsychiatrica,
L T Young, and
P P Li, and
S J Kish, and
K P Siu, and
J J Warsh
September 1996,
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
L T Young, and
P P Li, and
S J Kish, and
K P Siu, and
J J Warsh
May 1996,
The British journal of psychiatry : the journal of mental science,
L T Young, and
P P Li, and
S J Kish, and
K P Siu, and
J J Warsh
August 1997,
The American journal of psychiatry,
