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Cellular and humoral responses to Leishmania major virulence factors in healed cutaneous leishmaniasis and Mediterranean visceral leishmaniasis patients. 2009
Inès Lakhal-Naouar, and
Thouraya Boussoffara, and
Amel Meddeb-Garnaoui, and
Yosser Ben Achour-Chenik, and
Hechmi Louzir, and
Mehdi Chenik
Institut Pasteur de Tunis, BP 74, 13, Place Pasteur, 1002 Tunis, Tunisia. mehdi.chenik@pasteur.rns.tn.
Cellular and humoral immune responses of healed cutaneous leishmaniasis and Mediterranean visceral leishmaniasis patients were evaluated against results for Leishmania major virulence proteins L. major protein disulfide isomerase (LmPDI) and mitogen-activated protein kinase kinase (MAPKK). Only MAPKK induces significant peripheral blood mononuclear cell proliferation with gamma interferon production as well as antibody responses. Thus, MAPKK may be of interest in Leishmania vaccination and serodiagnosis.
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