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Good response to lopinavir/ritonavir-containing antiretroviral regimens in antiretroviral-naive HIV-2-infected patients. 2009
Antoine Bénard, and
Florence Damond, and
Pauline Campa, and
Gilles Peytavin, and
Diane Descamps, and
Caroline Lascoux-Combes, and
Audrey Taieb, and
François Simon, and
Brigitte Autran, and
Françoise Brun-Vézinet, and
Geneviève Chêne, and
Sophie Matheron, and
INSERM U897, CIC-EC 7, Université Victor Segalen Bordeaux 2, France. antoine.benard@isped.u-bordeaux2.fr
In 29 antiretroviral-naive HIV-2-infected patients starting lopinavir/ritonavir-containing regimen, the median CD4 cell count change from baseline (142 cells/microl) was +71 cells/microl at week 24 and +132 cells/microl at week 96. Seventeen (59%) patients had a CD4 cell count increase of at least 50 cells/microl and undetectable HIV-2 RNA at week 24 and were considered as responders to treatment. This sustained elevation of CD4 cell count in the first 2 years of combination antiretroviral therapy shows the potential for lopinavir/ritonavir regimens as first-line therapy in HIV-2 infection.
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