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Large peptides expressed from cDNA fragments of a clone encoding the mite allergen Der p I were able to bind IgE and IgG in sera from allergic individuals. The binding was found for peptides from sequences throughout the molecule, with at least five regions, comprising residues 1-56, 53-99, 98-140, 166-194, and 188-222. The only limitation was that more than 30 amino acid residues were required for consistent binding. Each of seven sera examined showed a different profile of antibody binding to the peptides. For the most part the pattern of IgE and IgG binding to the peptides for each serum was similar, demonstrating a concordant repertoire. In 5/7 sera, however, IgG bound to some peptides which had little or no IgE binding activity, thus showing more diverse specificities. It is suggested that some divergence of repertoire can develop during the maturation of the B cell response.
W K Greene, and
J G Cyster, and
K Y Chua, and
R M O'Brien, and
W R Thomas
February 1992,
Molecular immunology,
W K Greene, and
J G Cyster, and
K Y Chua, and
R M O'Brien, and
W R Thomas
December 1991,
Journal of immunological methods,
W K Greene, and
J G Cyster, and
K Y Chua, and
R M O'Brien, and
W R Thomas
January 2021,
Scientific reports,
W K Greene, and
J G Cyster, and
K Y Chua, and
R M O'Brien, and
W R Thomas
October 2006,
The Journal of allergy and clinical immunology,
W K Greene, and
J G Cyster, and
K Y Chua, and
R M O'Brien, and
W R Thomas
December 2012,
Arhiv za higijenu rada i toksikologiju,
W K Greene, and
J G Cyster, and
K Y Chua, and
R M O'Brien, and
W R Thomas
January 1991,
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology,
W K Greene, and
J G Cyster, and
K Y Chua, and
R M O'Brien, and
W R Thomas
August 1993,
Journal of immunology (Baltimore, Md. : 1950),
W K Greene, and
J G Cyster, and
K Y Chua, and
R M O'Brien, and
W R Thomas
January 2015,
International archives of allergy and immunology,
W K Greene, and
J G Cyster, and
K Y Chua, and
R M O'Brien, and
W R Thomas
January 1993,
International archives of allergy and immunology,
W K Greene, and
J G Cyster, and
K Y Chua, and
R M O'Brien, and
W R Thomas
November 1995,
European journal of immunology,
