Antibody production and complement system in protein energy malnutrition. 1977

M Hafez, and G H Aref, and S W Mehareb, and A S Kassem, and H El-Tahhan, and Z Rizk, and R Mahfouz, and K Saad

Antibody production in kwashiorkor and marasmic infants was studied by dividing them into three groups and giving the first group a single dose of trivalent live attenuated polio virus, the second group live attenuated measles virus and the third group diphtheriatoxoid. The production of antibodies was found to be deficient in PEM as compared to normals and diminished more in kwashiorkor than in marasmus cases. The individuals of the complement system were significantly lower in kwashiorkor than in normal controls. However, C3 was the only fraction which is significantly diminished in marasmic infants. The results are discussed and as a conclusion it is suggested that deficient production of antibodies and diminution in the complement system in PEM may explain the susceptibility of such infants to repeated attacks of infection.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D007732 Kwashiorkor A syndrome produced by severe protein deficiency, characterized by retarded growth, changes in skin and hair pigment, edema, and pathologic changes in the liver, including fatty infiltration, necrosis, and fibrosis. The word is a local name in Gold Coast, Africa, meaning "displaced child". Although first reported from Africa, kwashiorkor is now known throughout the world, but mainly in the tropics and subtropics. It is considered to be related to marasmus. (From Dorland, 27th ed) Kwashiorkors
D008297 Male Males
D011502 Protein-Energy Malnutrition The lack of sufficient energy or protein to meet the body's metabolic demands, as a result of either an inadequate dietary intake of protein, intake of poor quality dietary protein, increased demands due to disease, or increased nutrient losses. Marasmus,Protein-Calorie Malnutrition,Malnutrition, Protein-Calorie,Malnutrition, Protein-Energy,Malnutritions, Protein-Energy,Protein Calorie Malnutrition,Protein Energy Malnutrition
D003165 Complement System Proteins Serum glycoproteins participating in the host defense mechanism of COMPLEMENT ACTIVATION that creates the COMPLEMENT MEMBRANE ATTACK COMPLEX. Included are glycoproteins in the various pathways of complement activation (CLASSICAL COMPLEMENT PATHWAY; ALTERNATIVE COMPLEMENT PATHWAY; and LECTIN COMPLEMENT PATHWAY). Complement Proteins,Complement,Complement Protein,Hemolytic Complement,Complement, Hemolytic,Protein, Complement,Proteins, Complement,Proteins, Complement System
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000914 Antibodies, Viral Immunoglobulins produced in response to VIRAL ANTIGENS. Viral Antibodies
D000917 Antibody Formation The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS. Antibody Production,Antibody Response,Antibody Responses,Formation, Antibody,Production, Antibody,Response, Antibody,Responses, Antibody
D017955 Poliovirus A species of ENTEROVIRUS which is the causal agent of POLIOMYELITIS in humans. Three serotypes (strains) exist. Transmission is by the fecal-oral route, pharyngeal secretions, or mechanical vector (flies). Vaccines with both inactivated and live attenuated virus have proven effective in immunizing against the infection. Brunhilde Virus,Human poliovirus 1,Human poliovirus 2,Human poliovirus 3,Lansing Virus,Leon Virus,Poliovirus Type 1,Poliovirus Type 2,Poliovirus Type 3,Polioviruses

Related Publications

M Hafez, and G H Aref, and S W Mehareb, and A S Kassem, and H El-Tahhan, and Z Rizk, and R Mahfouz, and K Saad
September 1973, The Journal of tropical medicine and hygiene,
M Hafez, and G H Aref, and S W Mehareb, and A S Kassem, and H El-Tahhan, and Z Rizk, and R Mahfouz, and K Saad
June 1999, Journal of tropical pediatrics,
M Hafez, and G H Aref, and S W Mehareb, and A S Kassem, and H El-Tahhan, and Z Rizk, and R Mahfouz, and K Saad
November 1978, Clinical and experimental immunology,
M Hafez, and G H Aref, and S W Mehareb, and A S Kassem, and H El-Tahhan, and Z Rizk, and R Mahfouz, and K Saad
July 1992, Journal of the neurological sciences,
M Hafez, and G H Aref, and S W Mehareb, and A S Kassem, and H El-Tahhan, and Z Rizk, and R Mahfouz, and K Saad
January 1992, Allergologia et immunopathologia,
M Hafez, and G H Aref, and S W Mehareb, and A S Kassem, and H El-Tahhan, and Z Rizk, and R Mahfouz, and K Saad
May 1981, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
M Hafez, and G H Aref, and S W Mehareb, and A S Kassem, and H El-Tahhan, and Z Rizk, and R Mahfouz, and K Saad
October 2009, Pediatric clinics of North America,
M Hafez, and G H Aref, and S W Mehareb, and A S Kassem, and H El-Tahhan, and Z Rizk, and R Mahfouz, and K Saad
November 1988, Hospital practice (Office ed.),
M Hafez, and G H Aref, and S W Mehareb, and A S Kassem, and H El-Tahhan, and Z Rizk, and R Mahfouz, and K Saad
January 1976, Monograph series. World Health Organization,
M Hafez, and G H Aref, and S W Mehareb, and A S Kassem, and H El-Tahhan, and Z Rizk, and R Mahfouz, and K Saad
January 1978, Transactions of the Royal Society of Tropical Medicine and Hygiene,
Copied contents to your clipboard!