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Cerebrospinal fluid (CSF) and serum samples from 16 HIV-seropositive subjects were examined by ELISA and isoelectric focusing for the presence of HIV-specific immunoglobulin G (IgG) subclass antibodies. Autochthonous synthesis of IgG in the CSF was demonstrated in 11 patients. Intrathecally synthesized antibodies specific for individual HIV structural proteins were largely restricted to IgG1 (10 of 11 patients). One patient revealed additional local synthesis of IgG2 antibodies related to HIV-p15. In another patient locally produced antibodies specific for HIV consisted entirely of IgG4. In this patient amounts of locally produced antibodies were too low to be detected by routine procedures (calculation from an evaluation graph). No local synthesis of HIV-related IgG3 was demonstrated in any patient. Further studies will be needed to show whether determination of IgG-subclass-restricted antibodies to HIV is of prognostic value.
R Kaiser, and
R Dörries, and
B Ruf, and
H D Pohle, and
R Martin, and
V ter Meulen
January 1970,
Clinical and experimental immunology,
R Kaiser, and
R Dörries, and
B Ruf, and
H D Pohle, and
R Martin, and
V ter Meulen
January 1985,
Journal of clinical microbiology,
R Kaiser, and
R Dörries, and
B Ruf, and
H D Pohle, and
R Martin, and
V ter Meulen
August 1988,
AIDS (London, England),
R Kaiser, and
R Dörries, and
B Ruf, and
H D Pohle, and
R Martin, and
V ter Meulen
January 1987,
International archives of allergy and applied immunology,
R Kaiser, and
R Dörries, and
B Ruf, and
H D Pohle, and
R Martin, and
V ter Meulen
January 2013,
Clinical transplants,
R Kaiser, and
R Dörries, and
B Ruf, and
H D Pohle, and
R Martin, and
V ter Meulen
July 1987,
Clinical immunology and immunopathology,
R Kaiser, and
R Dörries, and
B Ruf, and
H D Pohle, and
R Martin, and
V ter Meulen
January 1993,
Autoimmunity,
R Kaiser, and
R Dörries, and
B Ruf, and
H D Pohle, and
R Martin, and
V ter Meulen
January 1995,
Journal of gastroenterology and hepatology,
R Kaiser, and
R Dörries, and
B Ruf, and
H D Pohle, and
R Martin, and
V ter Meulen
January 1995,
Annales de dermatologie et de venereologie,
R Kaiser, and
R Dörries, and
B Ruf, and
H D Pohle, and
R Martin, and
V ter Meulen
February 1983,
Infection and immunity,
