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The oncogenicity of BK virus for the central nervous system was studied in newborn hamsters. The virus was weakly oncogenic after intracerebral inoculation. Two of 45 hamsters treated with antithymocyte serum developed tumors whereas no untreated hamsters developed tumors. Both tumors were choroid plexus papillomas by histologic and electron microscopic examination. Cells cultured from one tumor had growth characteristics of transformed cells and had intranuclear T antigen; but infectious virus could not be rescued. Cultured tumor cells were weakly oncogenic for hamsters, but theoncogenicity of these cells was enhanced when the recipient animals were treated with antithymocyte serum. The possible role of host immune response as a basis for the weak oncogenicity of BK virus is discussed.
J E Greenlee, and
O Narayan, and
R T Johnson, and
R M Herndon
August 1973,
Science (New York, N.Y.),
J E Greenlee, and
O Narayan, and
R T Johnson, and
R M Herndon
September 1978,
Journal of the National Cancer Institute,
J E Greenlee, and
O Narayan, and
R T Johnson, and
R M Herndon
July 1979,
Journal of the National Cancer Institute,
J E Greenlee, and
O Narayan, and
R T Johnson, and
R M Herndon
August 1976,
Journal of the National Cancer Institute,
J E Greenlee, and
O Narayan, and
R T Johnson, and
R M Herndon
April 1975,
Journal of the National Cancer Institute,
J E Greenlee, and
O Narayan, and
R T Johnson, and
R M Herndon
October 1976,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
J E Greenlee, and
O Narayan, and
R T Johnson, and
R M Herndon
December 1979,
Journal of virology,
J E Greenlee, and
O Narayan, and
R T Johnson, and
R M Herndon
January 1980,
Microbiology and immunology,
J E Greenlee, and
O Narayan, and
R T Johnson, and
R M Herndon
December 1976,
Gan,
J E Greenlee, and
O Narayan, and
R T Johnson, and
R M Herndon
November 1974,
Journal of medical microbiology,
