BIOMAT Database Logo BIOMAT Database Logo

Oncogenic osteomalacia caused by a phosphaturic mesenchymal tumor of the thoracic spine. 2009

Elena Pirola, and Francesco Vergani, and Paolo Casiraghi, and Eugenio Biagio Leone, and Paolo Guerra, and Erik Pietro Sganzerla
Neurosurgery, University of Milano-Bicocca, Monza, Italy. oxosintesi@libero.it

Phosphaturic mesenchymal tumors that cause the paraneoplastic syndrome known as oncogenic osteomalacia are rare. The authors report on the case of a 57-year-old man with a history of osteomalacia and in whom was diagnosed a thoracic spine tumor at the T-4 level. Complete tumor resection was accomplished. The histological diagnosis was phosphaturic mesenchymal tumor (mixed connective tissue variant). After lesion removal, the paraneoplastic syndrome resolved. At the 24-month follow-up, no recurrence of the disease was observed. The clinical presentation, surgical technique, and follow-up in this case were reviewed in detail.

UI MeSH Term Description Entries
D007015 Hypophosphatemia, Familial An inherited condition of abnormally low serum levels of PHOSPHATES (below 1 mg/liter) which can occur in a number of genetic diseases with defective reabsorption of inorganic phosphorus by the PROXIMAL RENAL TUBULES. This leads to phosphaturia, HYPOPHOSPHATEMIA, and disturbances of cellular and organ functions such as those in X-LINKED HYPOPHOSPHATEMIC RICKETS; OSTEOMALACIA; and FANCONI SYNDROME. Diabetes, Phosphate,Familial Hypophosphatemia,Hyperphosphaturia,Phosphate Diabetes,Phosphaturia,Familial Hypophosphatemias,Hypophosphatemias, Familial
D008279 Magnetic Resonance Imaging Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques. Chemical Shift Imaging,MR Tomography,MRI Scans,MRI, Functional,Magnetic Resonance Image,Magnetic Resonance Imaging, Functional,Magnetization Transfer Contrast Imaging,NMR Imaging,NMR Tomography,Tomography, NMR,Tomography, Proton Spin,fMRI,Functional Magnetic Resonance Imaging,Imaging, Chemical Shift,Proton Spin Tomography,Spin Echo Imaging,Steady-State Free Precession MRI,Tomography, MR,Zeugmatography,Chemical Shift Imagings,Echo Imaging, Spin,Echo Imagings, Spin,Functional MRI,Functional MRIs,Image, Magnetic Resonance,Imaging, Magnetic Resonance,Imaging, NMR,Imaging, Spin Echo,Imagings, Chemical Shift,Imagings, Spin Echo,MRI Scan,MRIs, Functional,Magnetic Resonance Images,Resonance Image, Magnetic,Scan, MRI,Scans, MRI,Shift Imaging, Chemical,Shift Imagings, Chemical,Spin Echo Imagings,Steady State Free Precession MRI
D008297 Male Males
D008637 Mesenchymoma A mixed mesenchymal tumor composed of two or more mesodermal cellular elements not commonly associated, not counting fibrous tissue as one of the elements. Mesenchymomas are widely distributed in the body and about 75% are malignant. (Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1866) Mesenchymomas
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010018 Osteomalacia Disorder caused by an interruption of the mineralization of organic bone matrix leading to bone softening, bone pain, and weakness. It is the adult form of rickets resulting from disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis. Adult Rickets,Rickets, Adult
D010257 Paraneoplastic Syndromes In patients with neoplastic diseases a wide variety of clinical pictures which are indirect and usually remote effects produced by tumor cell metabolites or other products. Paraneoplastic Syndrome,Syndrome, Paraneoplastic,Syndromes, Paraneoplastic
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013123 Spinal Fusion Operative immobilization or ankylosis of two or more vertebrae by fusion of the vertebral bodies with a short bone graft or often with diskectomy or laminectomy. (From Blauvelt & Nelson, A Manual of Orthopaedic Terminology, 5th ed, p236; Dorland, 28th ed) Spondylodesis,Spondylosyndesis,Fusion, Spinal,Fusions, Spinal,Spinal Fusions,Spondylodeses,Spondylosyndeses
D013125 Spinal Neoplasms New abnormal growth of tissue in the SPINE. Neoplasm, Spinal,Neoplasms, Spinal,Spinal Neoplasm

Related Publications

Elena Pirola, and Francesco Vergani, and Paolo Casiraghi, and Eugenio Biagio Leone, and Paolo Guerra, and Erik Pietro Sganzerla
Oncogenic osteomalacia caused by phosphaturic mesenchymal tumor of the temporal bone.
October 2006, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery,
Elena Pirola, and Francesco Vergani, and Paolo Casiraghi, and Eugenio Biagio Leone, and Paolo Guerra, and Erik Pietro Sganzerla
Tumor-induced osteomalacia caused by phosphaturic mesenchymal tumor of the cervical spine.
July 2015, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association,
Elena Pirola, and Francesco Vergani, and Paolo Casiraghi, and Eugenio Biagio Leone, and Paolo Guerra, and Erik Pietro Sganzerla
Thoracic phosphaturic mesenchymal tumors causing oncogenic osteomalacia.
August 2013, Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia,
Elena Pirola, and Francesco Vergani, and Paolo Casiraghi, and Eugenio Biagio Leone, and Paolo Guerra, and Erik Pietro Sganzerla
Oncogenic osteomalacia due to phosphaturic mesenchymal tumour in the upper thoracic spine.
December 2020, BMJ case reports,
Elena Pirola, and Francesco Vergani, and Paolo Casiraghi, and Eugenio Biagio Leone, and Paolo Guerra, and Erik Pietro Sganzerla
Oncogenic osteomalacia caused by a phosphaturic mesenchymal tumor of the femur: A case report.
August 2019, World journal of clinical cases,
Elena Pirola, and Francesco Vergani, and Paolo Casiraghi, and Eugenio Biagio Leone, and Paolo Guerra, and Erik Pietro Sganzerla
Oncogenic osteomalacia caused by a phosphaturic mesenchymal tumor of the oral cavity: a case report.
January 1997, The Korean journal of internal medicine,
Elena Pirola, and Francesco Vergani, and Paolo Casiraghi, and Eugenio Biagio Leone, and Paolo Guerra, and Erik Pietro Sganzerla
Tumor-induced osteomalacia caused by a phosphaturic mesenchymal tumor of the femur.
October 2019, Chinese medical journal,
Elena Pirola, and Francesco Vergani, and Paolo Casiraghi, and Eugenio Biagio Leone, and Paolo Guerra, and Erik Pietro Sganzerla
[Tumor-induced osteomalacia caused by a late-revealing phosphaturic mesenchymal tumor].
June 2017, La Revue de medecine interne,
Elena Pirola, and Francesco Vergani, and Paolo Casiraghi, and Eugenio Biagio Leone, and Paolo Guerra, and Erik Pietro Sganzerla
Phosphaturic mesenchymal tumor, mixed connective tissue variant (oncogenic osteomalacia).
March 1996, Pathology international,
Elena Pirola, and Francesco Vergani, and Paolo Casiraghi, and Eugenio Biagio Leone, and Paolo Guerra, and Erik Pietro Sganzerla
Recurrent malignant variant of phosphaturic mesenchymal tumor with oncogenic osteomalacia.
February 2001, Skeletal radiology,
Copied contents to your clipboard!