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The effect of different calcium concentrations as well as dibutyryl-cyclic adenosine 3',5'-monophosphate (DB-cAMP) on the secretion of parathyroid hormone by human parathyroid adenomas taken from patients with primary hyperparathyroidism (pHPT) was studied in organ culture. Their influence on the release of hormone was determined. The tissue was incubated in culture medium for 4 h; the medium was changed hourly and analyzed for immunoreactive parathyroid hormone (PTH) by radioimmunoassay. The hormone secretion showed an inverse relationship to different calcium concentrations in the medium and could be stimulated independently of the calcium concentration by adding DB-cAMP. These results suggest that the examined parathyroid adenomas are sensitive to physiological stimuli.
M Dietel, and
G Dorn, and
R Montz, and
E Altenähr
February 1988,
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
M Dietel, and
G Dorn, and
R Montz, and
E Altenähr
September 1976,
Science (New York, N.Y.),
M Dietel, and
G Dorn, and
R Montz, and
E Altenähr
February 1975,
Endocrinology,
M Dietel, and
G Dorn, and
R Montz, and
E Altenähr
April 1973,
Biomedicine / [publiee pour l'A.A.I.C.I.G.],
M Dietel, and
G Dorn, and
R Montz, and
E Altenähr
January 1994,
Mineral and electrolyte metabolism,
M Dietel, and
G Dorn, and
R Montz, and
E Altenähr
January 1970,
Proceedings of the Koninklijke Nederlandse Akademie van Wetenschappen. Series C. Biological and medical sciences,
M Dietel, and
G Dorn, and
R Montz, and
E Altenähr
January 1979,
The Journal of clinical endocrinology and metabolism,
M Dietel, and
G Dorn, and
R Montz, and
E Altenähr
June 1981,
The American journal of physiology,
M Dietel, and
G Dorn, and
R Montz, and
E Altenähr
November 1972,
Science (New York, N.Y.),
M Dietel, and
G Dorn, and
R Montz, and
E Altenähr
April 1964,
Laboratory investigation; a journal of technical methods and pathology,
