Biomaterial Database

[Interaction between Actinobacillus pleuropneumoniae RTX toxin and host--a review]. 2009

Shengxian Fan, and Hui Liu, and Yang Chen, and Huanchun Chen, and Qigai He

Key laboratory of Preventive Veterinary Medicine of Hubei Province, Veterinary Medicine College, Huazhong Agricultural University, Wuhan 430070, China.

Actinobacillus pleuropneumoniae (App) is the etiological agent of porcine pleuropneumonia which causes huge economic losses to the pig industry. RTX (repeat in the structural toxin, RTX) is the main virulence-associated factor of the pathogen and, plays a dual role on the pathogen's infection and immunity. Recently research progress is updated in this paper and the necessity and techniques to initiate the pathogen-host interaction study is also raised and discussed. It is believed that the research on the interaction between host and App RTX may further elucidate the pathogen' s molecular pathogenesis.

UI	MeSH Term	Description	Entries
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001427	Bacterial Toxins	Toxic substances formed in or elaborated by bacteria; they are usually proteins with high molecular weight and antigenicity; some are used as antibiotics and some to skin test for the presence of or susceptibility to certain diseases.	Bacterial Toxin,Toxins, Bacterial,Toxin, Bacterial
D013553	Swine Diseases	Diseases of domestic swine and of the wild boar of the genus Sus.	Disease, Swine,Diseases, Swine,Swine Disease
D016977	Actinobacillus pleuropneumoniae	A species of gram-negative, facultatively anaerobic coccobacillus-shaped bacteria that has been isolated from pneumonic lesions and blood. It produces pneumonia with accompanying fibrinous pleuritis in swine.	Haemophilus pleuropneumoniae,Hemophilus pleuropneumoniae
D054884	Host-Pathogen Interactions	The interactions between a host and a pathogen, usually resulting in disease.	Host Pathogen Interaction,Host-Pathogen Relations,Pathogen-Host Interaction,Pathogen-Host Interactions,Host Pathogen Interactions,Host Pathogen Relations,Host-Pathogen Interaction,Host-Pathogen Relation,Interaction, Host Pathogen,Interaction, Host-Pathogen,Interaction, Pathogen-Host,Interactions, Host Pathogen,Interactions, Host-Pathogen,Interactions, Pathogen-Host,Pathogen Host Interaction,Pathogen Host Interactions,Pathogen Interaction, Host,Pathogen Interactions, Host,Relation, Host-Pathogen,Relations, Host-Pathogen
D018410	Pneumonia, Bacterial	Inflammation of the lung parenchyma that is caused by bacterial infections.	Bacterial Pneumonia,Bacterial Pneumonias,Pneumonias, Bacterial
D037521	Virulence Factors	Those components of an organism that determine its capacity to cause disease but are not required for its viability per se. Two classes have been characterized: TOXINS, BIOLOGICAL and surface adhesion molecules that effect the ability of the microorganism to invade and colonize a host. (From Davis et al., Microbiology, 4th ed. p486)	Pathogenicity Factor,Pathogenicity Factors,Virulence Factor,Factor, Pathogenicity,Factor, Virulence,Factors, Pathogenicity,Factors, Virulence