Long-term hormone replacement therapy preserves bone mineral density in Turner syndrome. 2009

Line Cleemann, and Britta E Hjerrild, and Anna L Lauridsen, and Lene Heickendorff, and Jens S Christiansen, and Leif Mosekilde, and Claus H Gravholt
Pediatric Unit, Nordsjaellands Hospital Hillerød, DK-3400 Hillerød, Denmark.

BACKGROUND Reduced bone mineral density (BMD) and increased risk of fractures are present in many women with Turner syndrome (TS). OBJECTIVE Examine longitudinal changes in BMD in TS and relate changes to biochemical parameters. METHODS Prospective, pragmatic, and observational study. Examinations at baseline and follow-up (5.9+/-0.7 years). METHODS Tertiary hospital. METHODS Fifty-four women with TS (43.0+/-9.95 years). Interventions Hormone replacement therapy (HRT) and calcium and vitamin D supplementation. Main outcome measures BMD (g/cm(2)) measured at lumbar spine, hip, and the non-dominant forearm. Bone formation and resorption markers, sex hormones, IGF1, and maximal oxygen uptake. RESULTS At follow-up, forearm BMD, radius ultradistal BMD, and hip BMD remained unchanged, radius 1/3 BMD declined (0.601+/-0.059 vs 0.592+/-0.059, P=0.03), while spine BMD increased (0.972+/-0.139 vs 1.010+/-0.144, P<0.0005). Bone formation markers did not change over time in TS. Bone resorption markers decreased over time in TS. Testosterone, IGF1, and maximal oxygen uptake was significantly reduced in TS. CONCLUSIONS Longitudinal changes in BMD in TS were slight. BMD can be maintained at most sites in well-informed women with TS, being encouraged to maintain a healthy lifestyle, including HRT and intake of calcium and vitamin D.

UI MeSH Term Description Entries
D008137 Longitudinal Studies Studies in which variables relating to an individual or group of individuals are assessed over a period of time. Bogalusa Heart Study,California Teachers Study,Framingham Heart Study,Jackson Heart Study,Longitudinal Survey,Tuskegee Syphilis Study,Bogalusa Heart Studies,California Teachers Studies,Framingham Heart Studies,Heart Studies, Bogalusa,Heart Studies, Framingham,Heart Studies, Jackson,Heart Study, Bogalusa,Heart Study, Framingham,Heart Study, Jackson,Jackson Heart Studies,Longitudinal Study,Longitudinal Surveys,Studies, Bogalusa Heart,Studies, California Teachers,Studies, Jackson Heart,Studies, Longitudinal,Study, Bogalusa Heart,Study, California Teachers,Study, Longitudinal,Survey, Longitudinal,Surveys, Longitudinal,Syphilis Studies, Tuskegee,Syphilis Study, Tuskegee,Teachers Studies, California,Teachers Study, California,Tuskegee Syphilis Studies
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D001842 Bone and Bones A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principal cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX. Bone Tissue,Bone and Bone,Bone,Bones,Bones and Bone,Bones and Bone Tissue,Bony Apophyses,Bony Apophysis,Condyle,Apophyses, Bony,Apophysis, Bony,Bone Tissues,Condyles,Tissue, Bone,Tissues, Bone
D002118 Calcium A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D004967 Estrogens Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds. Estrogen,Estrogen Effect,Estrogen Effects,Estrogen Receptor Agonists,Estrogenic Agents,Estrogenic Compounds,Estrogenic Effect,Estrogenic Effects,Agents, Estrogenic,Agonists, Estrogen Receptor,Compounds, Estrogenic,Effects, Estrogen,Effects, Estrogenic,Receptor Agonists, Estrogen
D005260 Female Females
D006339 Heart Rate The number of times the HEART VENTRICLES contract per unit of time, usually per minute. Cardiac Rate,Chronotropism, Cardiac,Heart Rate Control,Heartbeat,Pulse Rate,Cardiac Chronotropy,Cardiac Chronotropism,Cardiac Rates,Chronotropy, Cardiac,Control, Heart Rate,Heart Rates,Heartbeats,Pulse Rates,Rate Control, Heart,Rate, Cardiac,Rate, Heart,Rate, Pulse
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

Line Cleemann, and Britta E Hjerrild, and Anna L Lauridsen, and Lene Heickendorff, and Jens S Christiansen, and Leif Mosekilde, and Claus H Gravholt
October 2004, The Journal of clinical endocrinology and metabolism,
Line Cleemann, and Britta E Hjerrild, and Anna L Lauridsen, and Lene Heickendorff, and Jens S Christiansen, and Leif Mosekilde, and Claus H Gravholt
January 2024, Journal of Korean medical science,
Line Cleemann, and Britta E Hjerrild, and Anna L Lauridsen, and Lene Heickendorff, and Jens S Christiansen, and Leif Mosekilde, and Claus H Gravholt
June 2007, Climacteric : the journal of the International Menopause Society,
Line Cleemann, and Britta E Hjerrild, and Anna L Lauridsen, and Lene Heickendorff, and Jens S Christiansen, and Leif Mosekilde, and Claus H Gravholt
June 2009, Journal of aging and health,
Line Cleemann, and Britta E Hjerrild, and Anna L Lauridsen, and Lene Heickendorff, and Jens S Christiansen, and Leif Mosekilde, and Claus H Gravholt
January 2003, Gynecologic and obstetric investigation,
Line Cleemann, and Britta E Hjerrild, and Anna L Lauridsen, and Lene Heickendorff, and Jens S Christiansen, and Leif Mosekilde, and Claus H Gravholt
June 2006, Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae,
Line Cleemann, and Britta E Hjerrild, and Anna L Lauridsen, and Lene Heickendorff, and Jens S Christiansen, and Leif Mosekilde, and Claus H Gravholt
January 2019, Bratislavske lekarske listy,
Line Cleemann, and Britta E Hjerrild, and Anna L Lauridsen, and Lene Heickendorff, and Jens S Christiansen, and Leif Mosekilde, and Claus H Gravholt
June 1990, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
Line Cleemann, and Britta E Hjerrild, and Anna L Lauridsen, and Lene Heickendorff, and Jens S Christiansen, and Leif Mosekilde, and Claus H Gravholt
January 2019, Frontiers in endocrinology,
Line Cleemann, and Britta E Hjerrild, and Anna L Lauridsen, and Lene Heickendorff, and Jens S Christiansen, and Leif Mosekilde, and Claus H Gravholt
September 2003, The American journal of medicine,
Copied contents to your clipboard!