BIOMAT Database Logo BIOMAT Database Logo

Estrogen pretreatment modulates morphine-induced conditioned place preference in ovariectomized mice. 2009

Hilda Mirbaha, and Mohammad Tabaeizadeh, and Hamidreza Shaterian-Mohammadi, and Pouya Tahsili-Fahadan, and Ahmad Reza Dehpour
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Estrogen is known to modulate the neurotransmission in the brain. The main aim of this study was to investigate the effects of estrogen on the rewarding properties of morphine using conditioned place preference (CPP) paradigm in adult female mice. The possible rewarding effect of estrogen was also examined in ovariectomized mice. Following a 6-day conditioning procedure, sham operated animals showed a significant preference towards the side previously paired with a range of morphine doses (2, 5 and 10--but not 20--mg/kg, SC). However, ovariectomized mice showed decreased CPP compared to gonadally intact mice with a right shift in their morphine dose-response curve. These effects were reversed by chronic daily administration of estradiol benzoate (EB; 20 microg/kg, SC). Furthermore, in ovariectomized mice, EB per se was able to induce CPP. In conclusion, our findings indicate that estradiol has a facilitating effect on morphine reward while its deficiency increases the threshold dose of morphine to induce CPP.

UI MeSH Term Description Entries
D009020 Morphine The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle. Morphine Sulfate,Duramorph,MS Contin,Morphia,Morphine Chloride,Morphine Sulfate (2:1), Anhydrous,Morphine Sulfate (2:1), Pentahydrate,Oramorph SR,SDZ 202-250,SDZ202-250,Chloride, Morphine,Contin, MS,SDZ 202 250,SDZ 202250,SDZ202 250,SDZ202250,Sulfate, Morphine
D010052 Ovariectomy The surgical removal of one or both ovaries. Castration, Female,Oophorectomy,Bilateral Ovariectomy,Bilateral Ovariectomies,Castrations, Female,Female Castration,Female Castrations,Oophorectomies,Ovariectomies,Ovariectomies, Bilateral,Ovariectomy, Bilateral
D003214 Conditioning, Classical Learning that takes place when a conditioned stimulus is paired with an unconditioned stimulus. Reflex, Conditioned,Classical Conditioning,Classical Conditionings,Conditioned Reflex,Conditionings, Classical
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004967 Estrogens Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds. Estrogen,Estrogen Effect,Estrogen Effects,Estrogen Receptor Agonists,Estrogenic Agents,Estrogenic Compounds,Estrogenic Effect,Estrogenic Effects,Agents, Estrogenic,Agonists, Estrogen Receptor,Compounds, Estrogenic,Effects, Estrogen,Effects, Estrogenic,Receptor Agonists, Estrogen
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus

Related Publications

Hilda Mirbaha, and Mohammad Tabaeizadeh, and Hamidreza Shaterian-Mohammadi, and Pouya Tahsili-Fahadan, and Ahmad Reza Dehpour
Conditioned place preference induced by morphine and morphine-6-glucuronide in mice.
October 2006, Pharmacology, biochemistry, and behavior,
Hilda Mirbaha, and Mohammad Tabaeizadeh, and Hamidreza Shaterian-Mohammadi, and Pouya Tahsili-Fahadan, and Ahmad Reza Dehpour
Effects of scopolamine on morphine-induced conditioned place preference in mice.
September 2007, Addiction biology,
Hilda Mirbaha, and Mohammad Tabaeizadeh, and Hamidreza Shaterian-Mohammadi, and Pouya Tahsili-Fahadan, and Ahmad Reza Dehpour
Reinstatement of morphine-induced conditioned place preference in mice by priming injections.
January 2003, Neural plasticity,
Hilda Mirbaha, and Mohammad Tabaeizadeh, and Hamidreza Shaterian-Mohammadi, and Pouya Tahsili-Fahadan, and Ahmad Reza Dehpour
Cross-tolerance between morphine- and nicotine-induced conditioned place preference in mice.
January 2003, Pharmacology, biochemistry, and behavior,
Hilda Mirbaha, and Mohammad Tabaeizadeh, and Hamidreza Shaterian-Mohammadi, and Pouya Tahsili-Fahadan, and Ahmad Reza Dehpour
Effects of Coptis japonica on morphine-induced conditioned place preference in mice.
July 2003, Archives of pharmacal research,
Hilda Mirbaha, and Mohammad Tabaeizadeh, and Hamidreza Shaterian-Mohammadi, and Pouya Tahsili-Fahadan, and Ahmad Reza Dehpour
TRPV1 modulates morphine-induced conditioned place preference via p38 MAPK in the nucleus accumbens.
September 2017, Behavioural brain research,
Hilda Mirbaha, and Mohammad Tabaeizadeh, and Hamidreza Shaterian-Mohammadi, and Pouya Tahsili-Fahadan, and Ahmad Reza Dehpour
Nicotine-induced conditioned place preference and conditioned place aversion in mice.
January 1995, Pharmacology, biochemistry, and behavior,
Hilda Mirbaha, and Mohammad Tabaeizadeh, and Hamidreza Shaterian-Mohammadi, and Pouya Tahsili-Fahadan, and Ahmad Reza Dehpour
Methamphetamine-induced conditioned place preference is facilitated by estradiol pretreatment in female mice.
December 2003, The Chinese journal of physiology,
Hilda Mirbaha, and Mohammad Tabaeizadeh, and Hamidreza Shaterian-Mohammadi, and Pouya Tahsili-Fahadan, and Ahmad Reza Dehpour
Carnosine ameliorates morphine-induced conditioned place preference in rats.
July 2007, Neuroscience letters,
Hilda Mirbaha, and Mohammad Tabaeizadeh, and Hamidreza Shaterian-Mohammadi, and Pouya Tahsili-Fahadan, and Ahmad Reza Dehpour
Pleiotrophin modulates morphine withdrawal but has no effects on morphine-conditioned place preference.
September 2015, Neuroscience letters,
Copied contents to your clipboard!