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In chemonucleolysis, accuracy of injection can be in doubt if the patient fails to respond. Discography preceding chemonucleolysis is associated with increased neurologic complications. Biplane fluoroscopy may fail to provide a clear picture on many occasions. The serum keratan sulphate levels were estimated in patients undergoing chemonucleolysis to ascertain if this could be used as a biochemical indicator to confirm accurate needle placement and to predict outcome. Serum keratan sulphate levels rose significantly following chemonucleolysis during the first 3 days (P less than 0.01). The rise was not significantly different, however, in patients who had improvement in their leg pain from those who did not improve (P = 0.35). Serum keratan sulphate level estimation before chemonucleolysis and at 24 or 48 hours following the procedure can be used to confirm accuracy of needle placement, but the rise in keratan sulphate is not predictive of the clinical outcome of the procedure.
K P Muralikuttan, and
I V Adair, and
G Roberts, and
W G Kernohan, and
E R Trimble, and
R A Mollan
December 1990,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
K P Muralikuttan, and
I V Adair, and
G Roberts, and
W G Kernohan, and
E R Trimble, and
R A Mollan
January 1989,
Arthritis and rheumatism,
K P Muralikuttan, and
I V Adair, and
G Roberts, and
W G Kernohan, and
E R Trimble, and
R A Mollan
May 1979,
Annals of clinical biochemistry,
K P Muralikuttan, and
I V Adair, and
G Roberts, and
W G Kernohan, and
E R Trimble, and
R A Mollan
September 1974,
Journal of molecular biology,
K P Muralikuttan, and
I V Adair, and
G Roberts, and
W G Kernohan, and
E R Trimble, and
R A Mollan
April 1991,
The Biochemical journal,
K P Muralikuttan, and
I V Adair, and
G Roberts, and
W G Kernohan, and
E R Trimble, and
R A Mollan
April 1994,
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies,
K P Muralikuttan, and
I V Adair, and
G Roberts, and
W G Kernohan, and
E R Trimble, and
R A Mollan
February 1988,
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie,
K P Muralikuttan, and
I V Adair, and
G Roberts, and
W G Kernohan, and
E R Trimble, and
R A Mollan
January 2020,
Advances in experimental medicine and biology,
K P Muralikuttan, and
I V Adair, and
G Roberts, and
W G Kernohan, and
E R Trimble, and
R A Mollan
June 1988,
Spine,
K P Muralikuttan, and
I V Adair, and
G Roberts, and
W G Kernohan, and
E R Trimble, and
R A Mollan
August 1990,
British journal of rheumatology,
