BIOMAT Database Logo BIOMAT Database Logo

Myelitis complicating systemic lupus erythematosus: successfully treated with corticosteroids and cyclophosphamide. 2009

Wafa Ammouri, and Zoubida Tazi Mezalek, and Hicham Harmouche, and Mohammed Aouni, and Mohammed Adnaoui, and Abdelaaziz Maaouni
Department of Internal Medicine, Ibn Sina Hospital, Rabat, Morocco. wafaammouri@hotmail.com

Systemic lupus erythematosus (SLE), a multisystem autoimmune disease with protean manifestations, occurs with neuropsychiatric manifestations in </=60% of patients. Myelitis is a rare but serious complication of SLE. The diagnosis of myelitis may be difficult, but magnetic resonance imaging is generally very useful in assessing the extension and severity of lupus-related myelitis. We present the case of a 22-year-old woman with SLE since age 18 who presented with bilateral leg paresis of 7 days' duration.

UI MeSH Term Description Entries
D008180 Lupus Erythematosus, Systemic A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Libman-Sacks Disease,Lupus Erythematosus Disseminatus,Systemic Lupus Erythematosus,Disease, Libman-Sacks,Libman Sacks Disease
D009188 Myelitis, Transverse Inflammation of a transverse portion of the spinal cord characterized by acute or subacute segmental demyelination or necrosis. The condition may occur sporadically, follow an infection or vaccination, or present as a paraneoplastic syndrome (see also ENCEPHALOMYELITIS, ACUTE DISSEMINATED). Clinical manifestations include motor weakness, sensory loss, and incontinence. (Adams et al., Principles of Neurology, 6th ed, pp1242-6) Demyelinative Myelitis,Transverse Myelitis,Myelitis, Acute Transverse,Myelitis, Necrotizing,Myelitis, Paraneoplastic,Myelitis, Postinfectious,Myelitis, Postvaccinal,Myelitis, Subacute Transverse,Postinfectious Myelitis,Transverse Myelopathy Syndrome,Acute Transverse Myelitis,Myelitides, Subacute Transverse,Myelitis, Demyelinative,Necrotizing Myelitis,Paraneoplastic Myelitis,Postvaccinal Myelitis,Subacute Transverse Myelitis,Transverse Myelitis, Acute,Transverse Myelitis, Subacute,Transverse Myelopathy Syndromes
D003520 Cyclophosphamide Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer. (+,-)-2-(bis(2-Chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-Oxide Monohydrate,B-518,Cyclophosphamide Anhydrous,Cyclophosphamide Monohydrate,Cyclophosphamide, (R)-Isomer,Cyclophosphamide, (S)-Isomer,Cyclophosphane,Cytophosphan,Cytophosphane,Cytoxan,Endoxan,NSC-26271,Neosar,Procytox,Sendoxan,B 518,B518,NSC 26271,NSC26271
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000305 Adrenal Cortex Hormones HORMONES produced by the ADRENAL CORTEX, including both steroid and peptide hormones. The major hormones produced are HYDROCORTISONE and ALDOSTERONE. Adrenal Cortex Hormone,Corticoid,Corticoids,Corticosteroid,Corticosteroids,Cortex Hormone, Adrenal,Hormone, Adrenal Cortex,Hormones, Adrenal Cortex
D055815 Young Adult A person between 19 and 24 years of age. Adult, Young,Adults, Young,Young Adults
D018501 Antirheumatic Agents Drugs that are used to treat RHEUMATOID ARTHRITIS. Anti-Rheumatic Agent,Anti-Rheumatic Drug,Antirheumatic Agent,Antirheumatic Disease-Modifying Second-Line Drug,Antirheumatic Drug,DMARD,Disease-Modifying Antirheumatic Drug,Disease-Modifying Antirheumatic Drugs,Anti-Rheumatic Agents,Anti-Rheumatic Agents, Non-Steroidal,Anti-Rheumatic Drugs,Antirheumatic Disease-Modifying Second-Line Drugs,Antirheumatic Drugs,Antirheumatic Drugs, Disease-Modifying,Disease-Modifying, Antirheumatic Second-Line Drugs,Agent, Anti-Rheumatic,Agent, Antirheumatic,Anti Rheumatic Agent,Anti Rheumatic Agents,Anti Rheumatic Agents, Non Steroidal,Anti Rheumatic Drug,Anti Rheumatic Drugs,Antirheumatic Disease Modifying Second Line Drug,Antirheumatic Disease Modifying Second Line Drugs,Antirheumatic Drug, Disease-Modifying,Antirheumatic Drugs, Disease Modifying,Disease Modifying Antirheumatic Drug,Disease Modifying Antirheumatic Drugs,Disease Modifying, Antirheumatic Second Line Drugs,Drug, Anti-Rheumatic,Drug, Antirheumatic,Drug, Disease-Modifying Antirheumatic,Non-Steroidal Anti-Rheumatic Agents

Related Publications

Wafa Ammouri, and Zoubida Tazi Mezalek, and Hicham Harmouche, and Mohammed Aouni, and Mohammed Adnaoui, and Abdelaaziz Maaouni
Terbinafine-induced subacute cutaneous lupus erythematosus in two patients with systemic lupus erythematosus successfully treated with topical corticosteroids.
August 2013, Postepy dermatologii i alergologii,
Wafa Ammouri, and Zoubida Tazi Mezalek, and Hicham Harmouche, and Mohammed Aouni, and Mohammed Adnaoui, and Abdelaaziz Maaouni
Intractable Hemophagocytic Syndrome Associated with Systemic Lupus Erythematosus Resistant to Corticosteroids and Intravenous Cyclophosphamide That Was Successfully Treated with Cyclosporine A.
September 2018, Internal medicine (Tokyo, Japan),
Wafa Ammouri, and Zoubida Tazi Mezalek, and Hicham Harmouche, and Mohammed Aouni, and Mohammed Adnaoui, and Abdelaaziz Maaouni
Bullous systemic lupus erythematosus successfully treated with rituximab.
June 2019, Cutis,
Wafa Ammouri, and Zoubida Tazi Mezalek, and Hicham Harmouche, and Mohammed Aouni, and Mohammed Adnaoui, and Abdelaaziz Maaouni
[Acute transverse myelitis in systemic lupus erythematosus: successful therapy with cyclophosphamide and prednisone].
January 1991, Schweizerische medizinische Wochenschrift,
Wafa Ammouri, and Zoubida Tazi Mezalek, and Hicham Harmouche, and Mohammed Aouni, and Mohammed Adnaoui, and Abdelaaziz Maaouni
Transverse myelitis with systemic lupus erythematosus.
June 1977, Journal of neurology,
Wafa Ammouri, and Zoubida Tazi Mezalek, and Hicham Harmouche, and Mohammed Aouni, and Mohammed Adnaoui, and Abdelaaziz Maaouni
Central nervous system vasculitis in systemic lupus erythematosus: a case successfully treated with cyclophosphamide and steroids.
December 1997, Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases,
Wafa Ammouri, and Zoubida Tazi Mezalek, and Hicham Harmouche, and Mohammed Aouni, and Mohammed Adnaoui, and Abdelaaziz Maaouni
Kaposi Sarcoma complicating systemic lupus erythematosus treated with immunosuppression.
October 1974, Archives of dermatology,
Wafa Ammouri, and Zoubida Tazi Mezalek, and Hicham Harmouche, and Mohammed Aouni, and Mohammed Adnaoui, and Abdelaaziz Maaouni
Transverse myelitis complicating systemic lupus erythematosus: treatment including hydroxychloroquine. Case report.
June 1993, American journal of physical medicine & rehabilitation,
Wafa Ammouri, and Zoubida Tazi Mezalek, and Hicham Harmouche, and Mohammed Aouni, and Mohammed Adnaoui, and Abdelaaziz Maaouni
Plasmapheresis combined with corticosteroids and cyclophosphamide in uncontrolled active systemic lupus erythematosus.
January 1979, The Journal of rheumatology,
Wafa Ammouri, and Zoubida Tazi Mezalek, and Hicham Harmouche, and Mohammed Aouni, and Mohammed Adnaoui, and Abdelaaziz Maaouni
[Thrombotic thrombocytopenic purpura in a patient with systemic lupus erythematosus successfully treated with plasma exchange and corticosteroids].
August 2007, Polskie Archiwum Medycyny Wewnetrznej,
Copied contents to your clipboard!