BIOMAT Database Logo BIOMAT Database Logo

Recurrence of granulomatous interstitial nephritis in transplanted kidney. 2010

Federico Vargas, and Abraham Gedalia, and Randall D Craver, and V Matti Vehaskari
Departments of Pediatrics and Pathology, Children's Hospital and Louisiana Health Sciences Center, New Orleans, LA 70118,USA.

Sarcoidosis is a multisystemic disease of unknown etiology. Minor renal involvement is not rare but kidney failure is uncommon and only rare cases of recurrent disease in a kidney transplant have been published. We report a patient who at age 10 yr developed ESRD secondary to renal sarcoidosis with GIN. Her disease subsequently recurred in the transplanted kidney despite standard immunosuppression with prednisone, tacrolimus, and mycophenolate mofetil. The recurrent disease appeared to respond to increased immunosuppression, which included infliximab. However, the patient died of disseminated histoplasmosis three yr post-transplant.

UI MeSH Term Description Entries
D007166 Immunosuppressive Agents Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging. Immunosuppressant,Immunosuppressive Agent,Immunosuppressants,Agent, Immunosuppressive,Agents, Immunosuppressive
D007676 Kidney Failure, Chronic The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION. ESRD,End-Stage Renal Disease,Renal Disease, End-Stage,Renal Failure, Chronic,Renal Failure, End-Stage,Chronic Kidney Failure,End-Stage Kidney Disease,Chronic Renal Failure,Disease, End-Stage Kidney,Disease, End-Stage Renal,End Stage Kidney Disease,End Stage Renal Disease,End-Stage Renal Failure,Kidney Disease, End-Stage,Renal Disease, End Stage,Renal Failure, End Stage
D009395 Nephritis, Interstitial Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES and/or surrounding interstitium. For primary inflammation of glomerular interstitium, see GLOMERULONEPHRITIS. Infiltration of the inflammatory cells into the interstitial compartment results in EDEMA, increased spaces between the tubules, and tubular renal dysfunction. Interstitial Nephritis,Nephritis, Tubulointerstitial,Tubulointerstitial Nephritis,Interstitial Nephritides,Nephritides, Interstitial,Nephritides, Tubulointerstitial,Tubulointerstitial Nephritides
D012008 Recurrence The return of a sign, symptom, or disease after a remission. Recrudescence,Relapse,Recrudescences,Recurrences,Relapses
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D012507 Sarcoidosis An idiopathic systemic inflammatory granulomatous disorder comprised of epithelioid and multinucleated giant cells with little necrosis. It usually invades the lungs with fibrosis and may also involve lymph nodes, skin, liver, spleen, eyes, phalangeal bones, and parotid glands. Besnier-Boeck Disease,Boeck's Sarcoid,Besnier-Boeck-Schaumann Syndrome,Boeck Disease,Boeck's Disease,Schaumann Disease,Schaumann Syndrome,Schaumann's Syndrome,Besnier Boeck Disease,Besnier Boeck Schaumann Syndrome,Boeck Sarcoid,Boecks Disease,Boecks Sarcoid,Disease, Schaumann,Sarcoid, Boeck's,Sarcoidoses,Schaumann's Syndromes,Syndrome, Besnier-Boeck-Schaumann,Syndrome, Schaumann,Syndrome, Schaumann's
D016030 Kidney Transplantation The transference of a kidney from one human or animal to another. Grafting, Kidney,Renal Transplantation,Transplantation, Kidney,Transplantation, Renal,Kidney Grafting,Kidney Transplantations,Renal Transplantations,Transplantations, Kidney,Transplantations, Renal
D017809 Fatal Outcome Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept. Fatal Outcomes,Outcome, Fatal,Outcomes, Fatal

Related Publications

Federico Vargas, and Abraham Gedalia, and Randall D Craver, and V Matti Vehaskari
Granulomatous interstitial nephritis.
January 1984, Advances in nephrology from the Necker Hospital,
Federico Vargas, and Abraham Gedalia, and Randall D Craver, and V Matti Vehaskari
Granulomatous interstitial nephritis.
March 2007, Clinical journal of the American Society of Nephrology : CJASN,
Federico Vargas, and Abraham Gedalia, and Randall D Craver, and V Matti Vehaskari
[Granulomatous interstitial nephritis].
January 1997, Ryoikibetsu shokogun shirizu,
Federico Vargas, and Abraham Gedalia, and Randall D Craver, and V Matti Vehaskari
Granulomatous interstitial nephritis.
February 2013, Clinical and experimental nephrology,
Federico Vargas, and Abraham Gedalia, and Randall D Craver, and V Matti Vehaskari
Granulomatous interstitial nephritis.
December 1995, Human pathology,
Federico Vargas, and Abraham Gedalia, and Randall D Craver, and V Matti Vehaskari
Granulomatous interstitial nephritis.
March 2003, American journal of kidney diseases : the official journal of the National Kidney Foundation,
Federico Vargas, and Abraham Gedalia, and Randall D Craver, and V Matti Vehaskari
Granulomatous interstitial nephritis.
October 2015, Clinical kidney journal,
Federico Vargas, and Abraham Gedalia, and Randall D Craver, and V Matti Vehaskari
Ipilimumab granulomatous interstitial nephritis.
January 2015, American journal of therapeutics,
Federico Vargas, and Abraham Gedalia, and Randall D Craver, and V Matti Vehaskari
Granulomatous Interstitial Nephritis: A Rare Cause of Acute Kidney Injury.
November 2018, Journal of the College of Physicians and Surgeons--Pakistan : JCPSP,
Federico Vargas, and Abraham Gedalia, and Randall D Craver, and V Matti Vehaskari
Sarcoidosis and the kidney: not only the granulomatous interstitial nephritis.
February 2009, Clinical nephrology,
Copied contents to your clipboard!