Clinical implications of cortical microvasculature in adult Moyamoya disease. 2009

Marcus Czabanka, and Pablo Peña-Tapia, and Gerrit Alexander Schubert, and Johannes Woitzik, and Peter Horn, and Peter Schmiedek, and Peter Vajkoczy
Department of Neurosurgery, Charité-Universitätsmedizin Berlin, Campus Virchow Klinikum, Augustenburgerplatz 1, Berlin 13353, Germany. marcus.czabanka@charite.de

We analyzed cortical microvascular parameters using intraoperative ICG (Indocyaninegreen)-Videoangiography in 13 patients with Moyamoya disease, and carried out correlative studies by comparing them with clinical parameters obtained by digital subtraction angiography, physical examination, and regional cerebral blood flow studies. Patients with reduced cerebrovascular reserve capacity were characterized by increased microvascular surface area (MVSA). In addition, MVSA correlated positively with arterial microvascular transit time. Asymptomatic patients were characterized by increased arterial microvascular transit time. We show that patients with a higher arteriogenic potential to alter cortical microvasculature are characterized by a more favorable hemodynamic situation and reduced clinical symptoms.

UI MeSH Term Description Entries
D007208 Indocyanine Green A tricarbocyanine dye that is used diagnostically in liver function tests and to determine blood volume and cardiac output. Cardio-Green,Cardiogreen,Ujoveridin,Vofaverdin,Vophaverdin,Wofaverdin,Cardio Green,Green, Indocyanine
D008297 Male Males
D008833 Microcirculation The circulation of the BLOOD through the MICROVASCULAR NETWORK. Microvascular Blood Flow,Microvascular Circulation,Blood Flow, Microvascular,Circulation, Microvascular,Flow, Microvascular Blood,Microvascular Blood Flows,Microvascular Circulations
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009072 Moyamoya Disease A noninflammatory, progressive occlusion of the intracranial CAROTID ARTERIES and the formation of netlike collateral arteries arising from the CIRCLE OF WILLIS. Cerebral angiogram shows the puff-of-smoke (moyamoya) collaterals at the base of the brain. It is characterized by endothelial HYPERPLASIA and FIBROSIS with thickening of arterial walls. This disease primarily affects children but can also occur in adults. Cerebrovascular Moyamoya Disease,Progressive Intracranial Occlusive Arteropathy (Moyamoya),Moya-Moya Disease,Moyamoya Disease, Classic,Moyamoya Disease, Primary,Moyamoya Disease, Secondary,Moyamoya Syndrome,Classic Moyamoya Disease,Disease, Classic Moyamoya,Disease, Moya-Moya,Disease, Primary Moyamoya,Moya Moya Disease,Moyamoya Diseases, Primary,Primary Moyamoya Disease,Primary Moyamoya Diseases,Secondary Moyamoya Disease
D001783 Blood Flow Velocity A value equal to the total volume flow divided by the cross-sectional area of the vascular bed. Blood Flow Velocities,Flow Velocities, Blood,Flow Velocity, Blood,Velocities, Blood Flow,Velocity, Blood Flow
D002533 Cerebral Angiography Radiography of the vascular system of the brain after injection of a contrast medium. Angiography, Cerebral,Angiographies, Cerebral,Cerebral Angiographies
D002540 Cerebral Cortex The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulci. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions. Allocortex,Archipallium,Cortex Cerebri,Cortical Plate,Paleocortex,Periallocortex,Allocortices,Archipalliums,Cerebral Cortices,Cortex Cerebrus,Cortex, Cerebral,Cortical Plates,Paleocortices,Periallocortices,Plate, Cortical
D002560 Cerebrovascular Circulation The circulation of blood through the BLOOD VESSELS of the BRAIN. Brain Blood Flow,Regional Cerebral Blood Flow,Cerebral Blood Flow,Cerebral Circulation,Cerebral Perfusion Pressure,Circulation, Cerebrovascular,Blood Flow, Brain,Blood Flow, Cerebral,Brain Blood Flows,Cerebral Blood Flows,Cerebral Circulations,Cerebral Perfusion Pressures,Circulation, Cerebral,Flow, Brain Blood,Flow, Cerebral Blood,Perfusion Pressure, Cerebral,Pressure, Cerebral Perfusion
D003936 Diagnosis, Computer-Assisted Application of computer programs designed to assist the physician in solving a diagnostic problem. Computer-Assisted Diagnosis,Computer Assisted Diagnosis,Computer-Assisted Diagnoses,Diagnoses, Computer-Assisted,Diagnosis, Computer Assisted

Related Publications

Marcus Czabanka, and Pablo Peña-Tapia, and Gerrit Alexander Schubert, and Johannes Woitzik, and Peter Horn, and Peter Schmiedek, and Peter Vajkoczy
March 2007, Surgical neurology,
Marcus Czabanka, and Pablo Peña-Tapia, and Gerrit Alexander Schubert, and Johannes Woitzik, and Peter Horn, and Peter Schmiedek, and Peter Vajkoczy
January 2014, Cerebrovascular diseases (Basel, Switzerland),
Marcus Czabanka, and Pablo Peña-Tapia, and Gerrit Alexander Schubert, and Johannes Woitzik, and Peter Horn, and Peter Schmiedek, and Peter Vajkoczy
August 2022, World neurosurgery,
Marcus Czabanka, and Pablo Peña-Tapia, and Gerrit Alexander Schubert, and Johannes Woitzik, and Peter Horn, and Peter Schmiedek, and Peter Vajkoczy
January 2004, JBR-BTR : organe de la Societe royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie (KBVR),
Marcus Czabanka, and Pablo Peña-Tapia, and Gerrit Alexander Schubert, and Johannes Woitzik, and Peter Horn, and Peter Schmiedek, and Peter Vajkoczy
September 1996, The Journal of the Association of Physicians of India,
Marcus Czabanka, and Pablo Peña-Tapia, and Gerrit Alexander Schubert, and Johannes Woitzik, and Peter Horn, and Peter Schmiedek, and Peter Vajkoczy
November 1993, BMJ (Clinical research ed.),
Marcus Czabanka, and Pablo Peña-Tapia, and Gerrit Alexander Schubert, and Johannes Woitzik, and Peter Horn, and Peter Schmiedek, and Peter Vajkoczy
October 1993, BMJ (Clinical research ed.),
Marcus Czabanka, and Pablo Peña-Tapia, and Gerrit Alexander Schubert, and Johannes Woitzik, and Peter Horn, and Peter Schmiedek, and Peter Vajkoczy
October 2005, Stroke,
Marcus Czabanka, and Pablo Peña-Tapia, and Gerrit Alexander Schubert, and Johannes Woitzik, and Peter Horn, and Peter Schmiedek, and Peter Vajkoczy
December 2021, International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience,
Marcus Czabanka, and Pablo Peña-Tapia, and Gerrit Alexander Schubert, and Johannes Woitzik, and Peter Horn, and Peter Schmiedek, and Peter Vajkoczy
July 2019, World neurosurgery,
Copied contents to your clipboard!