Biomaterial Database

Persistent pupillary dilation in herpes simplex uveitis. 2009

Debra A Goldstein, and Andrew A Mis, and Frederick S Oh, and Jean G Deschenes

University of Illinois at Chicago Eye and Ear Infirmary, 60612-7243, USA. debrgold@uic.edu

OBJECTIVE To report the association between herpes simplex virus (HSV) and iris atrophy with pupillary dilation. METHODS Retrospective case series. METHODS Patients with a clinical diagnosis of HSV keratouveitis seen between November 1993 and April 1994 in a single university uveitis clinic. There were 6 women and 7 men, aged 17 to 69 years (mean age 44.4 years). METHODS Patient information was collected, including history and medications used, and a complete ophthalmologic evaluation was performed, with careful documentation of iris detail and pupillary size. RESULTS Thirteen of 13 patients demonstrated some degree of iris atrophy; 9 of 13 had pupillary dilation on the affected side despite not being on dilating drops. CONCLUSIONS Iris atrophy and pupillary dilation in a patient with unexplained anterior uveitis suggests the diagnosis of HSV keratouveitis.

UI	MeSH Term	Description	Entries
D007498	Iris	The most anterior portion of the uveal layer, separating the anterior chamber from the posterior. It consists of two layers - the stroma and the pigmented epithelium. Color of the iris depends on the amount of melanin in the stroma on reflection from the pigmented epithelium.
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D011681	Pupil Disorders	Conditions which affect the structure or function of the pupil of the eye, including disorders of innervation to the pupillary constrictor or dilator muscles, and disorders of pupillary reflexes.	Afferent Pupillary Defect,Efferent Pupillary Defect,Marcus-Gunn Pupil,Pupil Reaction Absent,Pupillary Functions, Abnormal,Deformed Pupil,Ectopic Pupil,Fixed Pupils,Keyhole Pupil,Non-Syphilitic Argyll-Robertson Pupil,Occluded Pupils,Pupil Malformations,Pupillary Anomaly,Pupillary Disorders,Pupillary Occlusion,Pupillary Paralysis,Pupillary Sector Paralysis,Pupillary Sphincter Rupture,Sector Pupil Palsy,Wernicke Hemianopic Pupil,Wernicke's Hemianopic Pupil,Abnormal Pupillary Function,Abnormal Pupillary Functions,Afferent Pupillary Defects,Anomalies, Pupillary,Anomaly, Pupillary,Argyll-Robertson Pupil, Non-Syphilitic,Deformed Pupils,Ectopic Pupils,Efferent Pupillary Defects,Fixed Pupil,Hemianopic Pupil, Wernicke,Hemianopic Pupil, Wernicke's,Keyhole Pupils,Malformation, Pupil,Malformations, Pupil,Marcus Gunn Pupil,Non Syphilitic Argyll Robertson Pupil,Occluded Pupil,Occlusion, Pupillary,Occlusions, Pupillary,Paralyses, Pupillary,Paralyses, Pupillary Sector,Paralysis, Pupillary,Paralysis, Pupillary Sector,Pupil Disorder,Pupil Malformation,Pupil, Deformed,Pupil, Ectopic,Pupil, Fixed,Pupil, Keyhole,Pupil, Marcus-Gunn,Pupil, Non-Syphilitic Argyll-Robertson,Pupil, Occluded,Pupil, Wernicke Hemianopic,Pupil, Wernicke's Hemianopic,Pupillary Anomalies,Pupillary Defect, Afferent,Pupillary Defect, Efferent,Pupillary Defects, Afferent,Pupillary Defects, Efferent,Pupillary Disorder,Pupillary Function, Abnormal,Pupillary Occlusions,Pupillary Paralyses,Pupillary Sector Paralyses,Pupillary Sphincter Ruptures,Pupils, Deformed,Pupils, Ectopic,Pupils, Fixed,Pupils, Keyhole,Pupils, Occluded,Reaction Absent, Pupil,Reaction Absents, Pupil,Rupture, Pupillary Sphincter,Ruptures, Pupillary Sphincter,Sector Paralyses, Pupillary,Sector Paralysis, Pupillary,Sphincter Rupture, Pupillary,Sphincter Ruptures, Pupillary,Wernickes Hemianopic Pupil
D005260	Female		Females
D005500	Follow-Up Studies	Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.	Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D006561	Herpes Simplex	A group of acute infections caused by herpes simplex virus type 1 or type 2 that is characterized by the development of one or more small fluid-filled vesicles with a raised erythematous base on the skin or mucous membrane. It occurs as a primary infection or recurs due to a reactivation of a latent infection. (Dorland, 27th ed.)	Herpes Simplex Virus Infection
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults