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During hypoglycemia induced by an infusion of porcine insulin, impaired suppression of endogenous insulin secretion as measured by C-peptide was demonstrated in 11 of 12 patients with insulinoma. During hypoglycemia (plasma glucose less than or equal to 40 mg/dl) the mean C-peptide immunoreactivity (CPR) of normal subjects was less than or equal to 1.2 ng/ml, whereas 11 of 12 insulinoma patients had a mean CPR of larger than or equal to 1.9 ng/ml. One patient showed normal CPR suppression by these criteria but may have shown impaired CPR suppression for glucose less than or equal to 30 mg/dl. Impaired CPR suppression during insulin-induced hypoglycemia may prove to be a useful test for insulinoma.
F J Service, and
D L Horwitz, and
A H Rubenstein, and
H Kuzuya, and
M E Mako, and
C Reynolds, and
G D Molnar
March 1989,
The American journal of medicine,
F J Service, and
D L Horwitz, and
A H Rubenstein, and
H Kuzuya, and
M E Mako, and
C Reynolds, and
G D Molnar
January 1992,
The Journal of clinical endocrinology and metabolism,
F J Service, and
D L Horwitz, and
A H Rubenstein, and
H Kuzuya, and
M E Mako, and
C Reynolds, and
G D Molnar
January 2002,
JOP : Journal of the pancreas,
F J Service, and
D L Horwitz, and
A H Rubenstein, and
H Kuzuya, and
M E Mako, and
C Reynolds, and
G D Molnar
October 1985,
Clinical endocrinology,
F J Service, and
D L Horwitz, and
A H Rubenstein, and
H Kuzuya, and
M E Mako, and
C Reynolds, and
G D Molnar
March 1982,
British medical journal (Clinical research ed.),
F J Service, and
D L Horwitz, and
A H Rubenstein, and
H Kuzuya, and
M E Mako, and
C Reynolds, and
G D Molnar
November 1981,
Klinische Wochenschrift,
F J Service, and
D L Horwitz, and
A H Rubenstein, and
H Kuzuya, and
M E Mako, and
C Reynolds, and
G D Molnar
March 1993,
The Journal of clinical endocrinology and metabolism,
F J Service, and
D L Horwitz, and
A H Rubenstein, and
H Kuzuya, and
M E Mako, and
C Reynolds, and
G D Molnar
January 1976,
Horumon to rinsho. Clinical endocrinology,
F J Service, and
D L Horwitz, and
A H Rubenstein, and
H Kuzuya, and
M E Mako, and
C Reynolds, and
G D Molnar
January 1983,
The Tohoku journal of experimental medicine,
F J Service, and
D L Horwitz, and
A H Rubenstein, and
H Kuzuya, and
M E Mako, and
C Reynolds, and
G D Molnar
March 1995,
Journal of surgical oncology,
