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1. Low dose (500 mg) paracetamol (acetaminophen) was administered to patients with rheumatoid arthritis (RA) and to age-matched healthy controls and to hospital controls. 2. At this dose level, patients with RA excreted decreased amounts of paracetamol sulphate (controls means 11.3 +/- 5.1, 10.6 +/- 5.9; RA mean 3.02 +/- 3.7). This difference is statistically significant (P less than 0.001). 3. The mean ratio of excretion of paracetamol sulphate/paracetamol glucuronide was 5.6 +/- 12.1, 5.3 +/- 10.7 in controls but 2.1 +/- 2.7 in RA patients (P less than 0.001). 4. Patients with RA appear to have less capacity for excreting paracetamol as non-toxic conjugates and may be more susceptible to paracetamol toxicity, especially on chronic dosage.
H Bradley, and
R H Waring, and
P Emery, and
V Arthur
January 1990,
Xenobiotica; the fate of foreign compounds in biological systems,
H Bradley, and
R H Waring, and
P Emery, and
V Arthur
November 1998,
The Journal of rheumatology,
H Bradley, and
R H Waring, and
P Emery, and
V Arthur
May 1990,
Lancet (London, England),
H Bradley, and
R H Waring, and
P Emery, and
V Arthur
October 1994,
British journal of rheumatology,
H Bradley, and
R H Waring, and
P Emery, and
V Arthur
December 2000,
Postgraduate medical journal,
H Bradley, and
R H Waring, and
P Emery, and
V Arthur
January 1993,
Agents and actions. Supplements,
H Bradley, and
R H Waring, and
P Emery, and
V Arthur
February 1989,
Journal of pharmaceutical sciences,
H Bradley, and
R H Waring, and
P Emery, and
V Arthur
April 1991,
Arthritis and rheumatism,
H Bradley, and
R H Waring, and
P Emery, and
V Arthur
November 1997,
The Journal of the Association of Physicians of India,
H Bradley, and
R H Waring, and
P Emery, and
V Arthur
November 1991,
Clinical pharmacology and therapeutics,
