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The extracellular (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) in rat striatum were measured by in vivo voltammetry to elucidate the effects of 3 tetrahydroprotoberberines on DA neurotransmission. l-tetrahydropalmatine (l-THP, 2 mg.kg-1) or l-stepholidine (l-SPD, 0.5 mg.kg-1) iv increased the striatal DA release by 225% and 233%, respectively; and l-SPD increased the DOPAC level by 70%. Moreover, the enantiomer d-THP (2 mg.kg-1) increased the DA release by 97%, and a large dose of d-THP (20 mg.kg-1) dramatically increased the extracellular DA by 1456% while it slightly elevated the DOPAC level by 123%. These results support the previous ideas that l-SPD and l-THP can block DA receptors and d-THP can deplete neuronal DA.
K X Huang, and
B C Sun, and
F G Gonon, and
G Z Jin
July 1991,
Brain research,
K X Huang, and
B C Sun, and
F G Gonon, and
G Z Jin
February 1987,
The Journal of pharmacy and pharmacology,
K X Huang, and
B C Sun, and
F G Gonon, and
G Z Jin
August 1992,
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae,
K X Huang, and
B C Sun, and
F G Gonon, and
G Z Jin
September 1986,
Brain research,
K X Huang, and
B C Sun, and
F G Gonon, and
G Z Jin
March 1988,
Neuroscience letters,
K X Huang, and
B C Sun, and
F G Gonon, and
G Z Jin
December 1980,
European journal of pharmacology,
K X Huang, and
B C Sun, and
F G Gonon, and
G Z Jin
September 2000,
Annals of the New York Academy of Sciences,
K X Huang, and
B C Sun, and
F G Gonon, and
G Z Jin
March 1973,
Journal of the neurological sciences,
K X Huang, and
B C Sun, and
F G Gonon, and
G Z Jin
April 1997,
Clinical science (London, England : 1979),
K X Huang, and
B C Sun, and
F G Gonon, and
G Z Jin
March 2023,
PNAS nexus,
