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Local deformation of extraocular muscles during eye movement. 2009

Marco Piccirelli, and Roger Luechinger, and Veit Sturm, and Peter Boesiger, and Klara Landau, and Oliver Bergamin
Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland.

OBJECTIVE To study extraocular muscle (EOM) function, the local physiologic contraction and elongation (deformation) along human horizontal EOMs were quantified by using motion-encoded magnetic resonance imaging (MRI). METHODS Eleven subjects (healthy right eye) gazed at a target that moved horizontally in a sinusoidal fashion (period, 2 seconds; amplitude, +/-20 degrees), during MRI with an optimized protocol. In addition, EOM longitudinal deformation in two patients with Duane's syndrome type I was analyzed. The horizontal EOMs and the optic nerve were tracked through 15 time frames, and their local deformation was calculated. Eight segments were separated along the EOMs and left-to-right and right-to-left eye movements were compared. RESULTS In healthy subjects, the maximum EOM deformation was situated at approximately two thirds of the muscle lengths from the scleral insertions. The EOM deformations were similar for the entire movement range as well as in both movement directions. In the two patients with Duane's syndrome type I, the abnormal innervation of lateral rectus muscle affected specific EOM segments only. The posterior muscle segments contracted and the anterior muscle segments relaxed during adduction. CONCLUSIONS Motion-encoded MRI is a useful technique for advancing the understanding of the physiology and pathophysiology of EOMs in humans during eye movement.

UI MeSH Term Description Entries
D008279 Magnetic Resonance Imaging Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques. Chemical Shift Imaging,MR Tomography,MRI Scans,MRI, Functional,Magnetic Resonance Image,Magnetic Resonance Imaging, Functional,Magnetization Transfer Contrast Imaging,NMR Imaging,NMR Tomography,Tomography, NMR,Tomography, Proton Spin,fMRI,Functional Magnetic Resonance Imaging,Imaging, Chemical Shift,Proton Spin Tomography,Spin Echo Imaging,Steady-State Free Precession MRI,Tomography, MR,Zeugmatography,Chemical Shift Imagings,Echo Imaging, Spin,Echo Imagings, Spin,Functional MRI,Functional MRIs,Image, Magnetic Resonance,Imaging, Magnetic Resonance,Imaging, NMR,Imaging, Spin Echo,Imagings, Chemical Shift,Imagings, Spin Echo,MRI Scan,MRIs, Functional,Magnetic Resonance Images,Resonance Image, Magnetic,Scan, MRI,Scans, MRI,Shift Imaging, Chemical,Shift Imagings, Chemical,Spin Echo Imagings,Steady State Free Precession MRI
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009119 Muscle Contraction A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments. Inotropism,Muscular Contraction,Contraction, Muscle,Contraction, Muscular,Contractions, Muscle,Contractions, Muscular,Inotropisms,Muscle Contractions,Muscular Contractions
D009126 Muscle Relaxation That phase of a muscle twitch during which a muscle returns to a resting position. Muscle Relaxations,Relaxation, Muscle,Relaxations, Muscle
D009801 Oculomotor Muscles The muscles that move the eye. Included in this group are the medial rectus, lateral rectus, superior rectus, inferior rectus, inferior oblique, superior oblique, musculus orbitalis, and levator palpebrae superioris. Extraocular Muscles,Extraocular Rectus Muscles,Inferior Oblique Extraocular Muscle,Inferior Oblique Muscles,Levator Palpebrae Superioris,Musculus Orbitalis,Oblique Extraocular Muscles,Oblique Muscle, Inferior,Oblique Muscle, Superior,Oblique Muscles, Extraocular,Rectus Muscles, Extraocular,Superior Oblique Extraocular Muscle,Superior Oblique Muscle,Extraocular Muscle,Extraocular Muscle, Oblique,Extraocular Muscles, Oblique,Extraocular Oblique Muscle,Extraocular Oblique Muscles,Extraocular Rectus Muscle,Inferior Oblique Muscle,Muscle, Oculomotor,Muscles, Oculomotor,Oblique Extraocular Muscle,Oblique Muscle, Extraocular,Oblique Muscles, Inferior,Oblique Muscles, Superior,Oculomotor Muscle,Rectus Muscle, Extraocular,Superior Oblique Muscles
D009802 Oculomotor Nerve The 3d cranial nerve. The oculomotor nerve sends motor fibers to the levator muscles of the eyelid and to the superior rectus, inferior rectus, and inferior oblique muscles of the eye. It also sends parasympathetic efferents (via the ciliary ganglion) to the muscles controlling pupillary constriction and accommodation. The motor fibers originate in the oculomotor nuclei of the midbrain. Cranial Nerve III,Third Cranial Nerve,Nerve III,Nervus Oculomotorius,Cranial Nerve IIIs,Cranial Nerve, Third,Cranial Nerves, Third,Nerve IIIs,Nerve, Oculomotor,Nerve, Third Cranial,Nerves, Oculomotor,Nerves, Third Cranial,Oculomotor Nerves,Oculomotorius, Nervus,Third Cranial Nerves
D004370 Duane Retraction Syndrome A syndrome characterized by marked limitation of abduction of the eye, variable limitation of adduction and retraction of the globe, and narrowing of the palpebral fissure on attempted adduction. The condition is caused by aberrant innervation of the lateral rectus by fibers of the OCULOMOTOR NERVE. Duane Syndrome,Ocular Retraction Syndrome,Acrorenoocular Syndrome,Co-Contractive Retraction Syndrome,Duane Anomaly,Duane Anomaly with Radial Abnormalities and Deafness,Duane Anomaly with Radial Ray Abnormalities and Deafness,Duane Anomaly, Isolated,Duane Retraction Syndrome 1,Duane Retraction Syndrome 2,Duane Retraction Syndrome, Type 1,Duane Retraction Syndrome, Type 2,Duane Retraction Syndrome, Type 3,Duane's Syndrome,Duane-Radial Ray Syndrome,Isolated Duane Retraction Syndrome,Okihiro Syndrome,Retraction Syndrome,Stilling-Turk-Duane Syndrome,Type 1 Duane Retraction Syndrome,Type 2 Duane Retraction Syndrome,Type 3 Duane Retraction Syndrome,Acrorenoocular Syndromes,Anomaly, Duane,Anomaly, Isolated Duane,Co Contractive Retraction Syndrome,Co-Contractive Retraction Syndromes,Duane Anomalies, Isolated,Duane Radial Ray Syndrome,Duanes Syndrome,Isolated Duane Anomalies,Isolated Duane Anomaly,Ocular Retraction Syndromes,Retraction Syndrome, Co-Contractive,Retraction Syndrome, Duane,Retraction Syndrome, Ocular,Retraction Syndromes,Stilling Turk Duane Syndrome,Stilling-Turk-Duane Syndromes,Syndrome, Acrorenoocular,Syndrome, Duane,Syndrome, Duane Retraction,Syndrome, Duane's,Syndrome, Duane-Radial Ray,Syndrome, Ocular Retraction,Syndrome, Okihiro
D005133 Eye Movements Voluntary or reflex-controlled movements of the eye. Eye Movement,Movement, Eye,Movements, Eye
D005260 Female Females

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