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21 patients with primary hyperlipoproteinemias of type IIb and IV were treated for 8 weeks with placebo, 8 weeks with 0.3 g butylbiguanide and 1.5 g clofibrate/day and then for 8 weeks with 1.5 g clofibrate/day. In 12 patients a second placebo phase of 8 weeks followed. After 8 weeks of combined treatment with butylbiguanide and clofibrate the serum triglycerides decreased from 725 mg to 269 mg/100 ml. During the following period of clofibrate treatment the serum triglycerides increased after 4 and 8 weeks to 326 mg and 306 mg/100 ml respectively. The combined treatment with 0.3 g butylbiguanide and 1.5 g clofibrate/day is more effective in lowering elevated serum triglycerides and cholesterol than 1.5 g clofibrate alone.
T Koschinsky, and
F A Gries, and
P Schwandt, and
P Weisweiler, and
W Hansen, and
J Nijssen, and
R Beckmann
March 1976,
Klinische Wochenschrift,
T Koschinsky, and
F A Gries, and
P Schwandt, and
P Weisweiler, and
W Hansen, and
J Nijssen, and
R Beckmann
December 1973,
Deutsche medizinische Wochenschrift (1946),
T Koschinsky, and
F A Gries, and
P Schwandt, and
P Weisweiler, and
W Hansen, and
J Nijssen, and
R Beckmann
October 1979,
Clinica chimica acta; international journal of clinical chemistry,
T Koschinsky, and
F A Gries, and
P Schwandt, and
P Weisweiler, and
W Hansen, and
J Nijssen, and
R Beckmann
January 1980,
Arzneimittel-Forschung,
T Koschinsky, and
F A Gries, and
P Schwandt, and
P Weisweiler, and
W Hansen, and
J Nijssen, and
R Beckmann
March 1976,
Deutsche medizinische Wochenschrift (1946),
T Koschinsky, and
F A Gries, and
P Schwandt, and
P Weisweiler, and
W Hansen, and
J Nijssen, and
R Beckmann
January 1974,
Giornale italiano di cardiologia,
T Koschinsky, and
F A Gries, and
P Schwandt, and
P Weisweiler, and
W Hansen, and
J Nijssen, and
R Beckmann
September 1976,
MMW, Munchener medizinische Wochenschrift,
T Koschinsky, and
F A Gries, and
P Schwandt, and
P Weisweiler, and
W Hansen, and
J Nijssen, and
R Beckmann
January 1972,
Polish medical journal,
T Koschinsky, and
F A Gries, and
P Schwandt, and
P Weisweiler, and
W Hansen, and
J Nijssen, and
R Beckmann
February 1978,
Medizinische Klinik,
T Koschinsky, and
F A Gries, and
P Schwandt, and
P Weisweiler, and
W Hansen, and
J Nijssen, and
R Beckmann
August 1977,
Klinische Wochenschrift,
