The influence of LH and/or FSH on Leydig and Sertoli cell morphology after testicular involution in the Djungarian hamster, Phodopus sungorus, induced by hypophysectomy or short photoperiods. 1991

S Kliesch, and B Schweifer, and P Niklowitz, and E Nieschlag, and M Bergmann
Department of Anatomy, University of Münster, Germany.

In the Djungarian hamster, Phodopus sungorus, the morphological alterations of Sertoli and Leydig cells were investigated under the influence of gonadotropins (LH and/or FSH) after testicular regression induced either by hypophysectomy or photoinhibition. Stimulation with LH or LH/FSH lead to a redifferentiation of morphological features of Leydig cells such as nuclear structure, smooth endoplasmic reticulum and size of cell and nucleus area within 7 days of hormone treatment. Similarly, stimulation with FSH or LH/FSH caused redifferentiation of Sertoli cell nuclear structure, rough endoplasmic reticulum and nuclear size within 7 days. Incomplete restoration of Leydig and Sertoli cell morphology was observed under FSH and LH treatment respectively. In both Leydig and Sertoli cells combined LH and FSH application resulted in an increased response in respect to morphological redifferentiation, possibly indicating paracrine regulatory mechanisms. In all groups treated an intact blood-testis barrier (BTB) was reestablished after a minimum of 7 days, indicating that the existence of the blood-testis barrier is not dependent on specific gonadotropin supply but on the developmental stage of the seminiferous epithelium. Sham-operated animals showed increased cell and nucleus area of Leydig cells in comparison to photostimulated animals. After testicular involution as well as after LH or FSH treatment there were no significant morphological differences between hypophysectomized and photoinhibited animals in respect to the documented ultrastructural and morphometrical characteristics.(ABSTRACT TRUNCATED AT 250 WORDS)

UI MeSH Term Description Entries
D007016 Hypophysectomy Surgical removal or destruction of the hypophysis, or pituitary gland. (Dorland, 28th ed) Hypophysectomies
D007985 Leydig Cells Steroid-producing cells in the interstitial tissue of the TESTIS. They are under the regulation of PITUITARY HORMONES; LUTEINIZING HORMONE; or interstitial cell-stimulating hormone. TESTOSTERONE is the major androgen (ANDROGENS) produced. Interstitial Cells, Testicular,Leydig Cell,Testicular Interstitial Cell,Testicular Interstitial Cells,Cell, Leydig,Cell, Testicular Interstitial,Cells, Leydig,Cells, Testicular Interstitial,Interstitial Cell, Testicular
D007986 Luteinizing Hormone A major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Luteinizing hormone regulates steroid production by the interstitial cells of the TESTIS and the OVARY. The preovulatory LUTEINIZING HORMONE surge in females induces OVULATION, and subsequent LUTEINIZATION of the follicle. LUTEINIZING HORMONE consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the three pituitary glycoprotein hormones (TSH, LH and FSH), but the beta subunit is unique and confers its biological specificity. ICSH (Interstitial Cell Stimulating Hormone),Interstitial Cell-Stimulating Hormone,LH (Luteinizing Hormone),Lutropin,Luteoziman,Luteozyman,Hormone, Interstitial Cell-Stimulating,Hormone, Luteinizing,Interstitial Cell Stimulating Hormone
D008027 Light That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range. Light, Visible,Photoradiation,Radiation, Visible,Visible Radiation,Photoradiations,Radiations, Visible,Visible Light,Visible Radiations
D008297 Male Males
D008854 Microscopy, Electron Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen. Electron Microscopy
D010507 Periodicity The tendency of a phenomenon to recur at regular intervals; in biological systems, the recurrence of certain activities (including hormonal, cellular, neural) may be annual, seasonal, monthly, daily, or more frequently (ultradian). Cyclicity,Rhythmicity,Biological Rhythms,Bioperiodicity,Biorhythms,Biological Rhythm,Bioperiodicities,Biorhythm,Cyclicities,Periodicities,Rhythm, Biological,Rhythmicities,Rhythms, Biological
D012098 Reproduction The total process by which organisms produce offspring. (Stedman, 25th ed) Human Reproductive Index,Human Reproductive Indexes,Reproductive Period,Human Reproductive Indices,Index, Human Reproductive,Indexes, Human Reproductive,Indices, Human Reproductive,Period, Reproductive,Periods, Reproductive,Reproductive Index, Human,Reproductive Indices, Human,Reproductive Periods
D001814 Blood-Testis Barrier A specialized barrier, in the TESTIS, between the interstitial BLOOD compartment and the adluminal compartment of the SEMINIFEROUS TUBULES. The barrier is formed by layers of cells from the VASCULAR ENDOTHELIUM of the capillary BLOOD VESSELS, to the SEMINIFEROUS EPITHELIUM of the seminiferous tubules. TIGHT JUNCTIONS form between adjacent SERTOLI CELLS, as well as between the ENDOTHELIAL CELLS. Testis-Blood Barrier,Barrier, Blood-Testis,Barrier, Testis-Blood,Barriers, Blood-Testis,Barriers, Testis-Blood,Blood Testis Barrier,Blood-Testis Barriers,Testis Blood Barrier,Testis-Blood Barriers
D002467 Cell Nucleus Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed) Cell Nuclei,Nuclei, Cell,Nucleus, Cell

Related Publications

S Kliesch, and B Schweifer, and P Niklowitz, and E Nieschlag, and M Bergmann
September 1978, Journal of reproduction and fertility,
S Kliesch, and B Schweifer, and P Niklowitz, and E Nieschlag, and M Bergmann
December 1990, International journal of andrology,
S Kliesch, and B Schweifer, and P Niklowitz, and E Nieschlag, and M Bergmann
January 1985, Endocrinology,
S Kliesch, and B Schweifer, and P Niklowitz, and E Nieschlag, and M Bergmann
January 1975, Experientia,
S Kliesch, and B Schweifer, and P Niklowitz, and E Nieschlag, and M Bergmann
August 1993, Biology of reproduction,
S Kliesch, and B Schweifer, and P Niklowitz, and E Nieschlag, and M Bergmann
February 2000, Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology,
S Kliesch, and B Schweifer, and P Niklowitz, and E Nieschlag, and M Bergmann
March 1993, Biology of reproduction,
S Kliesch, and B Schweifer, and P Niklowitz, and E Nieschlag, and M Bergmann
June 1978, Chromosoma,
S Kliesch, and B Schweifer, and P Niklowitz, and E Nieschlag, and M Bergmann
October 1988, Laboratory animals,
S Kliesch, and B Schweifer, and P Niklowitz, and E Nieschlag, and M Bergmann
January 1999, Veterinary ophthalmology,
Copied contents to your clipboard!