BIOMAT Database Logo BIOMAT Database Logo

HLA antigens in Italian patients with systemic lupus erythematosus: evidence for the association of DQw2 with the autoantibody response to extractable nuclear antigens. 1991

P Lulli, and G D Sebastiani, and S Trabace, and G Passiu, and S Cappellacci, and F Porzio, and M Morellini, and F Cutrupi, and M Galeazzi
Department of Experimental Medicine, Medical Genetics, Università La Sapienza, Rome, Italy.

In order to verify the hypothesis that Italian patients with systemic lupus erythematosus (SLE) may be immunogenetically distinct from SLE patients born in other regions, we investigated the HLA class I and II antigens and their relation with the various autoantibodies characteristic of the disease in an Italian SLE population. Forty-four SLE patients were typed for HLA-A, -B, -C, -DR and -DQ antigens; sera from the same patients were tested for the presence of antibodies to the nuclear or cytoplasmic antigens Ro/SSA, La/SSB, Sm and RNP (ENA). Results of HLA typing showed that the frequencies of DR3 and DQw2 were increased in patients compared with controls. Analysis of the correlations between HLA antigens and anti-ENA antibodies showed that both DQw2 and DR3 were increased in patients with anti-Ro and/or antiLa antibodies, while in patients with anti-Sm and/or antiRNP antibodies the DQw2 and DR4 were found to be increased. Only DQw2 was found to be significantly increased in anti-ENA positive patients. These results might suggest that Italian patients with SLE are, at least in part, different from lupus patients living in other geographical areas and suggest the association of DQw2 with the autoantibody response to ENA in SLE.

UI MeSH Term Description Entries
D007558 Italy A country in southern Europe, a peninsula extending into the central Mediterranean Sea, northeast of Tunisia. The capital is Rome. Sardinia
D008180 Lupus Erythematosus, Systemic A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Libman-Sacks Disease,Lupus Erythematosus Disseminatus,Systemic Lupus Erythematosus,Disease, Libman-Sacks,Libman Sacks Disease
D008297 Male Males
D006650 Histocompatibility Testing Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed) Crossmatching, Tissue,HLA Typing,Tissue Typing,Crossmatchings, Tissue,HLA Typings,Histocompatibility Testings,Testing, Histocompatibility,Testings, Histocompatibility,Tissue Crossmatching,Tissue Crossmatchings,Tissue Typings,Typing, HLA,Typing, Tissue,Typings, HLA,Typings, Tissue
D006680 HLA Antigens Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases. Human Leukocyte Antigen,Human Leukocyte Antigens,Leukocyte Antigens,HL-A Antigens,Antigen, Human Leukocyte,Antigens, HL-A,Antigens, HLA,Antigens, Human Leukocyte,Antigens, Leukocyte,HL A Antigens,Leukocyte Antigen, Human,Leukocyte Antigens, Human
D006683 HLA-DQ Antigens A group of the D-related HLA antigens found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases. HLA-DC Antigens,HLA-MB Antigens,HLA-DC,HLA-DQ,HLA-DS,HLA-DS Antigens,HLA-LB,HLA-LB Antigens,HLA-MB,Antigens, HLA-DC,Antigens, HLA-DQ,Antigens, HLA-DS,Antigens, HLA-LB,Antigens, HLA-MB,HLA DC Antigens,HLA DQ Antigens,HLA DS Antigens,HLA LB Antigens,HLA MB Antigens
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000917 Antibody Formation The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS. Antibody Production,Antibody Response,Antibody Responses,Formation, Antibody,Production, Antibody,Response, Antibody,Responses, Antibody
D001323 Autoantibodies Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them. Autoantibody

Related Publications

P Lulli, and G D Sebastiani, and S Trabace, and G Passiu, and S Cappellacci, and F Porzio, and M Morellini, and F Cutrupi, and M Galeazzi
HLA-DR antigens in systemic lupus erythematosus: association with specificity of autoantibody responses to nuclear antigens.
June 1987, Annals of the rheumatic diseases,
P Lulli, and G D Sebastiani, and S Trabace, and G Passiu, and S Cappellacci, and F Porzio, and M Morellini, and F Cutrupi, and M Galeazzi
[Antibodies to extractable nuclear antigens in systemic lupus erythematosus].
January 1982, Terapevticheskii arkhiv,
P Lulli, and G D Sebastiani, and S Trabace, and G Passiu, and S Cappellacci, and F Porzio, and M Morellini, and F Cutrupi, and M Galeazzi
[Antibodies to extractable nuclear antigens in systemic lupus erythematosus].
January 1979, Przeglad dermatologiczny,
P Lulli, and G D Sebastiani, and S Trabace, and G Passiu, and S Cappellacci, and F Porzio, and M Morellini, and F Cutrupi, and M Galeazzi
Antibodies to extractable nuclear antigens (ENAS) in systemic lupus erythematosus.
October 2019, Reumatismo,
P Lulli, and G D Sebastiani, and S Trabace, and G Passiu, and S Cappellacci, and F Porzio, and M Morellini, and F Cutrupi, and M Galeazzi
HLA antigens in Malay patients with systemic lupus erythematosus: association with clinical and autoantibody expression.
June 2001, The Korean journal of internal medicine,
P Lulli, and G D Sebastiani, and S Trabace, and G Passiu, and S Cappellacci, and F Porzio, and M Morellini, and F Cutrupi, and M Galeazzi
Longitudinal fluctuation of antibodies to extractable nuclear antigens in systemic lupus erythematosus.
July 2005, The Journal of rheumatology,
P Lulli, and G D Sebastiani, and S Trabace, and G Passiu, and S Cappellacci, and F Porzio, and M Morellini, and F Cutrupi, and M Galeazzi
[HLA antigens in systemic lupus erythematosus patients].
January 1984, Terapevticheskii arkhiv,
P Lulli, and G D Sebastiani, and S Trabace, and G Passiu, and S Cappellacci, and F Porzio, and M Morellini, and F Cutrupi, and M Galeazzi
Concentration of antibodies to extractable nuclear antigens and disease activity in systemic lupus erythematosus.
April 2009, Lupus,
P Lulli, and G D Sebastiani, and S Trabace, and G Passiu, and S Cappellacci, and F Porzio, and M Morellini, and F Cutrupi, and M Galeazzi
HLA antigens in Japanese patients with systemic lupus erythematosus.
January 1994, Scandinavian journal of rheumatology,
P Lulli, and G D Sebastiani, and S Trabace, and G Passiu, and S Cappellacci, and F Porzio, and M Morellini, and F Cutrupi, and M Galeazzi
HLA antigens in Malay patients with systemic lupus erythematosus.
October 1994, Lupus,
Copied contents to your clipboard!