BIOMAT Database Logo BIOMAT Database Logo

Anthracycline metabolites from Streptomyces violaceus A262. III. New anthracycline obelmycins produced by a variant strain SE2-2385. 1991

O Johdo, and Y Watanabe, and T Ishikura, and A Yoshimoto, and H Naganawa, and T Sawa, and T Takeuchi
Central Research Laboratories, Mercian Corporation, Fujisawa, Japan.

New anthracycline antibiotics, designated as obelmycins A, D, E, F and G, were isolated from the culture broth of a variant strain of beta-rhodomycin-producing Streptomyces violaceus A262, identified as beta-isorhodomycinone glycosides and gamma-isorhodomycinone glycosides and assayed for their in vitro cytotoxicities against murine leukemic L1210 cell culture and the antimicrobial activities in comparison with some known anthracyclines.

UI MeSH Term Description Entries
D009682 Magnetic Resonance Spectroscopy Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING). In Vivo NMR Spectroscopy,MR Spectroscopy,Magnetic Resonance,NMR Spectroscopy,NMR Spectroscopy, In Vivo,Nuclear Magnetic Resonance,Spectroscopy, Magnetic Resonance,Spectroscopy, NMR,Spectroscopy, Nuclear Magnetic Resonance,Magnetic Resonance Spectroscopies,Magnetic Resonance, Nuclear,NMR Spectroscopies,Resonance Spectroscopy, Magnetic,Resonance, Magnetic,Resonance, Nuclear Magnetic,Spectroscopies, NMR,Spectroscopy, MR
D002851 Chromatography, High Pressure Liquid Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed. Chromatography, High Performance Liquid,Chromatography, High Speed Liquid,Chromatography, Liquid, High Pressure,HPLC,High Performance Liquid Chromatography,High-Performance Liquid Chromatography,UPLC,Ultra Performance Liquid Chromatography,Chromatography, High-Performance Liquid,High-Performance Liquid Chromatographies,Liquid Chromatography, High-Performance
D002855 Chromatography, Thin Layer Chromatography on thin layers of adsorbents rather than in columns. The adsorbent can be alumina, silica gel, silicates, charcoals, or cellulose. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Chromatography, Thin-Layer,Thin Layer Chromatography,Chromatographies, Thin Layer,Chromatographies, Thin-Layer,Thin Layer Chromatographies,Thin-Layer Chromatographies,Thin-Layer Chromatography
D004353 Drug Evaluation, Preclinical Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications. Drug Screening,Evaluation Studies, Drug, Pre-Clinical,Drug Evaluation Studies, Preclinical,Drug Evaluations, Preclinical,Evaluation Studies, Drug, Preclinical,Evaluation, Preclinical Drug,Evaluations, Preclinical Drug,Medicinal Plants Testing, Preclinical,Preclinical Drug Evaluation,Preclinical Drug Evaluations,Drug Screenings,Screening, Drug,Screenings, Drug
D005285 Fermentation Anaerobic degradation of GLUCOSE or other organic nutrients to gain energy in the form of ATP. End products vary depending on organisms, substrates, and enzymatic pathways. Common fermentation products include ETHANOL and LACTIC ACID. Fermentations
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000903 Antibiotics, Antineoplastic Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms. Antineoplastic Antibiotics,Cytotoxic Antibiotics,Antibiotics, Cytotoxic
D001419 Bacteria One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive. Eubacteria
D013302 Streptomyces A genus of bacteria that form a nonfragmented aerial mycelium. Many species have been identified with some being pathogenic. This genus is responsible for producing a majority of the ANTI-BACTERIAL AGENTS of practical value.
D014407 Tumor Cells, Cultured Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely. Cultured Tumor Cells,Neoplastic Cells, Cultured,Cultured Neoplastic Cells,Cell, Cultured Neoplastic,Cell, Cultured Tumor,Cells, Cultured Neoplastic,Cells, Cultured Tumor,Cultured Neoplastic Cell,Cultured Tumor Cell,Neoplastic Cell, Cultured,Tumor Cell, Cultured

Related Publications

O Johdo, and Y Watanabe, and T Ishikura, and A Yoshimoto, and H Naganawa, and T Sawa, and T Takeuchi
Anthracycline metabolites from Streptomyces violaceus A262. IV. New anthracycline yellamycins produced by a variant strain SC-7.
October 1991, The Journal of antibiotics,
O Johdo, and Y Watanabe, and T Ishikura, and A Yoshimoto, and H Naganawa, and T Sawa, and T Takeuchi
Anthracycline metabolites from Streptomyces violaceus A262. I. Isolation of antibiotic-blocked mutants from Streptomyces violaceus A262.
October 1991, The Journal of antibiotics,
O Johdo, and Y Watanabe, and T Ishikura, and A Yoshimoto, and H Naganawa, and T Sawa, and T Takeuchi
Anthracycline metabolites from Streptomyces violaceus A262. V. New anthracycline alldimycin A: a minor component isolated from obelmycin beer.
October 1991, The Journal of antibiotics,
O Johdo, and Y Watanabe, and T Ishikura, and A Yoshimoto, and H Naganawa, and T Sawa, and T Takeuchi
New rhodomycin analogs, SS-288A and SS-288B, produced by a Streptomyces violaceus A262 mutant.
January 1995, Bioscience, biotechnology, and biochemistry,
O Johdo, and Y Watanabe, and T Ishikura, and A Yoshimoto, and H Naganawa, and T Sawa, and T Takeuchi
Anthracycline metabolites from baumycin-producing Streptomyces sp. D788. II. New anthracycline metabolites produced by a blocked mutant strain RPM-5.
January 1993, The Journal of antibiotics,
O Johdo, and Y Watanabe, and T Ishikura, and A Yoshimoto, and H Naganawa, and T Sawa, and T Takeuchi
Anthracycline metabolites from baumycin-producing Streptomyces sp. D788. III. New anthracycline metabolites produced by blocked mutants 4L-660 and YDK-18.
November 1993, The Journal of antibiotics,
O Johdo, and Y Watanabe, and T Ishikura, and A Yoshimoto, and H Naganawa, and T Sawa, and T Takeuchi
New anthracycline antibiotics produced by interspecific recombinants of streptomycetes. I. Selection of Streptomyces violaceus subsp. iremyceticus, an iremycin-producing subspecies.
January 1980, Zeitschrift fur allgemeine Mikrobiologie,
O Johdo, and Y Watanabe, and T Ishikura, and A Yoshimoto, and H Naganawa, and T Sawa, and T Takeuchi
New anthracycline metabolites produced by the aklavinone 11-hydroxylase gene in Streptomyces galilaeus ATCC 31133.
April 1996, The Journal of antibiotics,
O Johdo, and Y Watanabe, and T Ishikura, and A Yoshimoto, and H Naganawa, and T Sawa, and T Takeuchi
Cytotoxic Anthracycline Metabolites from a Recombinant Streptomyces.
May 2018, Journal of natural products,
O Johdo, and Y Watanabe, and T Ishikura, and A Yoshimoto, and H Naganawa, and T Sawa, and T Takeuchi
Further minor metabolites of staurosporine produced by a Streptomyces longisporoflavus strain.
June 1996, The Journal of antibiotics,
Copied contents to your clipboard!